Carla Lopes
239 820 190
Pos Doc
Group at CNC

- PhD in Experimental Biology and Biomedicine (BEB) in 2015, branch of Neuroscience and Disease, with a thesis entitled “Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease”.

- Integrated Master's (Bologna process) in Biomedical Engineering in Faculty of Sciences and Technology of the University of Coimbra, with specialization in Neurosciences in 2010



Area of Research: 

For the last years, my research has focused on Huntington's disease (HD) and different models phenotype. Initially I worked with a transgenic mouse model (YAC128) and evaluated the protective benefits of in vivo administration of insulin growth factor (IGF1).
Currently, my research focuses on the use of induced pluripotent stem cells (iPSC) derived from Huntington’s patients (juvenile form) to characterize disease mechanisms, including mitochondrial dysfunction and oxidative stress assuming that the iPSC can be consider a model for early stages. I also want to create new iPSC lines derived from HD patients (late onset), correct them genetically and characterize mitochondrial function and the role of oxidative stress in the pathogenesis of HD.

Research Summary:
Selected Publications: 

Lopes C, Ribeiro M, Duarte AI, Humbert S, Saudou F, Pereira de Almeida L, Hayden M, Rego AC. IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice. Mol Neurobiol. 2014 Jun;49(3):1126-42. doi: 10.1007/s12035-013-8585-5.

Lopes, C; Duarte, A.; Hayden, M.; Rego, AC. Peripheral and cerebral metabolic features in an animal model of Huntington's disease Bioengineering (ENBENG), 2012 IEEE 2nd Portuguese Meeting in Digital Object Identifier: 10.1109/ENBENG.2012.6331390 Publication Year: 2012, Page(s): 1-5 IEEE CONFERENCE PUBLICATIONS

Lopes, C, Rego, AC. “Revisiting mitochondrial function and metabolism in pluripotent stem cells: where do we stand in neurological diseases?” Mol Neurobiol (accepted).

Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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