Luana Naia
239 820 190
PhD student
Group at CNC

Luana Naia graduated in Genetic and Biotechnology from the University of Trás-os-Montes and Alto Douro, in 2008, and them obtained her master degree in Biotechnology of Health Sciences from the same university, where she was awarded with a merit scholarship prize (Prémio UTAD 2011). In 2012, Luana enrolled the inter-university doctoral programme in Ageing and Chronic Disease from the Faculty of Medicine of the University of Coimbra. A year later, she received a fellowship from FCT to develop her PhD thesis entitled “Role of lysine deacetylases on transcription regulation and mitochondrial function in Huntington’s disease”, under the supervision of Professor Ana Cristina Rego, from the Mitochondrial Dysfunction and Signaling in Neurodegeneration group, at CNC, where she is currently. Meanwhile, Luana has published 6 scientific articles and presented more than 20 oral and poster communications in national and international meetings. Since 2013 she also supervised laboratorial rotations of graduate students from the University of Coimbra and undergraduate students from exchange programs and collaborated in technical and scientific supervision of master students.




Area of Research: 

Luana's current research interests focus on mitochondrial-based neuroprotective strategies in Huntington's disease (HD), a motor neurodegenerative disorder caused by a polyglutamine repeat expansion. Particularly, she has been working in pharmacological and genetic modulation of zinc-dependent class I/II lysine deacetylases, and NAD+-dependent class III lysine deacetylases, also known as sirtuins, in both in vitro and in vivo HD models. More recently, she has focused on the role of sirtuin 3 in this motor disease, since it is the major deacetylase of mitochondria.


Research Summary:
Selected Publications: 

Naia L, Rego AC. 2015. Sirtuins: double players in Huntington's disease. Biochim Biophys Acta, 1852:2183-94. DOI: 10.1016/j.bbadis.2015.07.003; Impact factor: 4.882

Naia L*, Ferreira IL*, Cunha-Oliveira T, Duarte AI, Ribeiro M, Rosenstock TR, Laço MN, Ribeiro MJ, Oliveira CR, Saudou F, Humbert S, Rego AC. 2015. Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's disease human lymphoblasts. Mol Neurobiol., 51:331-48. (*contributed equally) DOI: 10.1007/s12035-014-8735-4; Impact factor: 5.137

Naia L, Ribeiro MJ, Rego AC. 2011. Mitochondrial and metabolic-based protective strategies in Huntington’s disease – the case of creatine and coenzyme Q. Rev Neurosci., 23: 13–28. DOI: 10.1515/RNS.2011.060; Impact factor: 3.330


Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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