Sandra Isabel Mota
(+351) 239 820 190
Post-doctoral fellow
Group at CNC

 graduated in Biomedical Biochemistry in 2006 at the Université René Descartes in Paris and completed my formation on the same university by a Master on Pharmacology and Toxicology under the supervision of Doctor Robert Baroukis's laboratory (INSERM U747), evaluating the effect of dioxine and alcohol on hepatocarcinoma progression.
In 2013, I obtained my PhD degree (Cellular Biology) by the Faculty of Sciences and Technology of Coimbra, working on the importance of NMDA Receptors for early Alzheimer's disease progression at the Center for Neurosciences and Cell Biology (CNBC) of Coimbra, under the supervision of the Doctor Ana Cristina Rego.
In 2014 I obtained a post-doctoral fellowship and I am now working in oxidative stress-associated pathways in neurodegenerative disorders (Alzheimer’s and Huntington’s disesases) under the main supervision of Doctor Ana Cristina Rego



Area of Research: 

I am actually interested in evaluate changes occurring in early stages of neurodegenerative disorders, namely Alzheimer’s disease and Huntington’s disease. In fact, there are growing evidences that some signalling pathways are affected in disease already during pre-symptomatic stages since. At this moment, my interest is focused on oxidative stress-associated signalling pathways and, in the case of Alzheimer’s disease, I maintain an interest in NMDARs changes as during my PhD and in the relation between NMDARs and oxidative stress.

Research Summary:
Selected Publications: 

Mota S.I., Costa R.O., Ferreira I.L., Santana I., Caldeira G.L., Padovano C., Fonseca A.C., Baldeiras I., Cunha C., Letra L., Oliveira C.R., Pereira C.M., Rego A.C. Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease. Biochim Biophys Acta. 2015 Jul;1852(7):1428-41. Epub 2015 Apr 6. IF 2015: 4.882

Mota S.I., Ferreira I.L., Valero J., Ferreiro E., Carvalho A.L., Oliveira C.R., Rego A.C. Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway. Experimental Neurology. 2014 Aug 13;261C:698-709. IF (2014)= 4.696

Mota S.I., Ferreira I.L., Rego A.C. Dysfunctional synapse in Alzheimer's disease - A focus on NMDA receptors. Neuropharmacology. 2014 Jan;76 :16-26. IF(2014)= 5.106

Mota S.I., Ferreira I.L., Pereira C., Oliveira C.R. and Rego A.C. Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures. Current Alzheimer's Research. 2012 Sep;9(7):844-56 IF(2012)= 3.676

Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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