Gabriela Jorge Da Silva / Gabriela Da Silva
Assistant Professor, tenure and Researcher (sub-PI) at CNC
Group at CNC

Degree in Pharmaceutical Sciences from the University of Coimbra.
PhD in Pharmacy in the specialty of Microbiology and Parasitology .
Assistant Professor at FFUC .
Researcher at the CEF until 2014.
Member of the Governing Council of FFUC between 2002-09.
Member of Antibiotic Resistance Prevention Group, DGS in 2007-08 .
Teaching courses of Clinical Bacteriology , Public Health and Food Safety in Bachelors and Masters Courses.
Supervision of  several students of Bachelor , Master and PhD .



Area of Research: 

Her research has been directed to the molecular epidemiology studies and antimicrobial resistance mechanisms in gram-negative bacilli as well as in the horizontal transfer of resistance genes in various ecological niches (clinical, animal, and environmental). She is interested in developing new strategies to combat infections caused by multidrug-resistant bacteria, namely by the knowledge of modulation of virulence factors and/or in developing new antibacterias.

Research Summary:
Selected Publications: 

1.    Figueiredo R, Card R, Nunes C, AbuOun M, Bagnall MC, Nunez J, Mendonça N, Anjum MF, da Silva GJ. (2015) Virulence Characterization of Salmonella enterica by a New Microarray: Detection and Evaluation of the Cytolethal Distending Toxin Gene Activity in the Unusual Host S. Typhimurium. PLoS One. 10: e0135010. IF 3.234
doi: 10.1371/journal.pone.0135010.

2.    Wallace JL, Blackler RW, Chan MV, Da Silva GJ, Elsheikh W, Flannigan KL, Gamaniek I, Manko A, Wang L, Motta JP, Buret AG. (2015) Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics. Antioxid Redox Signal. 22: 398-410.
IF 7.407
doi: 10.1089/ars.2014.5901.

3.    Vera Calhau, Luísa Boaventura, Graça Ribeiro, Nuno Mendonça, Gabriela J. da Silva. (2014) Molecular characterization of Klebsiella pneumoniae isolated from renal transplanted patients: virulence markers, extended-spectrum beta-lactamases and genetic relatedness. Diagnostic Microbiology and Infectious Disease, 79: 393–395
IF 2.457
doi: 0.1016/j.diagmicrobio.2013.08.031.

4.    Domingues S, Toleman MA, Nielsen KM, da Silva GJ. (2013) Identical miniature inverted repeat transposable elements flank class 1 integrons in clinical isolates of Acinetobacter spp. J Clin Microbiol. 51: 2382-2384. IF 3.993
doi: 10.1128/JCM.00692-13.

5.    Domingues S, Harms K, Florian Fricke W, Pål Jarle Johnsen, Da Silva GJ, Kaare Magne N  “Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species”, PLoSPathogens, 2012, 8, 1-15 (e1002837).
IF= 8.136

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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