Maria Manuel Cruz Silva
239 488 496
msilva@ff.uc.pt
Assistant Professor
Group at CNC
Education: 

Maria Manuel Cruz Silva is graduated in Pharmaceutical Sciences, has a master degree in Drugs Technologies and a PhD in Pharmaceutical Chemistry (2005), from the University of Coimbra in collaboration with the ICRM, CNR, Milan, Italy.
Maria Manuel is assistant professor of the Faculty of Pharmacy, University of Coimbra and has experience in applied biocatalysis and steroid´s medicinal chemistry.

 

Afiliation: 

FFUC & CNC

Area of Research: 

Medicinal Chemistry
Rational design, synthesis and evaluation of organic compounds with medicinal interest

Research Summary: 
http://orcid.org/0000-0002-1938-4150
Selected Publications: 

KASAL,  A.; BUDEŠÍNSKY´, M.; MAREŠ, P.; KRIŠTOFÍKOVÁ, Z.; LEITÃO, A. J.; SÁ E MELO, M. L.; SILVA, M. M.C.
Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alphahydroxyl group?
Steroids 105 (2016) 12–18

SALVADOR, J.A.R.; CARVALHO, J.F.S.; LEITÃO, A.J.; NEVES, M.A.C.; SILVA, M.M.C.; SILVESTRE, S.M.; SÁ E MELO, M.L.
Anticancer Steroids: Linking natural and semi-synthetic compounds,
Nat. Prod. Rep., 2013, 30, 324-374.

CARVALHO, J.F.S.; SILVA, M.M.C.; MOREIRA, J.N.; SIMÕES, S.; SÁ e MELO, M.L.
Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR.
J. Med. Chem., 2011, 54, 6375–6393. DOI: 10.1021/jm200803d

SILVA, M.M.C.; CARVALHO, J.F.S.; RIVA, S.; SÁ E MELO, M.L.
Biocatalytic Transformations of Steroids: Focus on Hydrolase-Catalyzed Reactions.
Curr. Org. Chemistry, 2011, 15, 6, 928-941. DOI: 10.2174/138527211794518871

 
   
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