João Soeiro Teodoro
239 855 760
Post-Doc researcher
Group at CNC

I finished my B.Sc. in Biology in 2005 at the University of Coimbra, Portugal, by completing a work on mitochondrial alterations caused by hepatic steatosis in a genetic rat model of obesity, which was published in 2006.
I immediately began my M.Sc. in Cellular and Molecular Biology (once more at UC), which was concluded in 2007, with a work dedicated to exploring the issue of hepatic steatosis, but in a different experimental perspective that focused on the effects of feeding animals a high-fat diet for several months. This work was published in 2008.
After this, I started my Ph.D. in Biosciences, specialty of Cellular and Molecular Biology (once more at UC, but this time involving the collaboration and my visit to research laboratories in the United States and the Czech Republic), which was concluded in 2012. The work performed during the Ph.D. tried to explore novel strategies to combat obesity and diabetes, with a particular focus on mitochondrial function. Of the tested strategies, I highlight the ones focused on the modulation of the glycolytic pathway, and the therapeutic use of the compounds berberine and chenodeoxycholic acid. These works were published in several papers (2013; 2013; 2014), along with several review papers (2011; 2013; 2014) and book chapters (2014; 2015).
Parallel to my work, I have participated in various works occurring in the lab, which permitted the publication of several papers (2008; 2009; 2010; 2010; 2011; 2012; 2012; 2012; 2012; 2013; 2013). I have currently also various works in the final stages of publication.
I was the tutor for 3 M.Sc. theses (two at the UC and one at the University of Aveiro, Portugal), and I was also the arguer of two M.Sc. candidates. Finally, I am also a reviewer for several international publications.



Area of Research: 

I am currently conducting my post-doc research on investigating the role of the bile acid chenodeoxycholic acid in the modulation of intracellular pathways of obesity reduction, with particular relevance for the role of the triglycerides/free-fatty acids cycle. By modulating several molecular receptors, key enzymes and with the use of powerful metabolic analysis techniques (ex: real-time PCR, Western Blot, mitochondrial activity evaluation, NMR, etc.) I was able to obtain some results with potential implication for the future.

Research Summary:
Selected Publications: 

•    Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes et al., Cell, 2013. IF=32.242
•    Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice. Teodoro et al., Int J Obesity 2013. IF=5.004
•    Hepatic FXR: Key regulator of whole-body energy metabolism. Teodoro et al., Trends Endocrinol Metab, 2011. IF=9.392
•    Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective. Teodoro et al., Toxicol in vitro, 2011. IF= 2.903
•    SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Price et al., Cell Metab, 2012. IF= 17.565

Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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