Sara Domingues
Assistant Professor FFUC
Group at CNC

- Degree in Pharmaceutical Sciences, Faculty of Pharmacy, University of Coimbra, in 2006.
- Master in Cell Biology, Faculty of Sciences and Technology, University of Coimbra, in 2009. FCT Master grant during the second year of the Master. The experimental work was conducted both at the Faculty of Pharmacy University of Coimbra and University of Tromsø, Norway.
- PhD in Pharmacy, specialisation in Microbiology and Parasitology, Faculty of Pharmacy, University of Coimbra, in 2013. FCT PhD grant, with the experimental work realized at the University of Coimbra and the University of Tromsø, Norway




Area of Research: 

My main scientific interest is the horizontal gene transfer, in particular natural transformation and the impact of this mechanism in the bacterial diversity and evolution. I try to understand the involvement of natural transformation in the spread and dynamics of mobile genetic elements, particularly those associated with antimicrobial resistance genes. The knowledge of the structures and mechanisms that facilitate the movement of antibiotic resistance genes is essential to develop effective measures for antimicrobial resistance control and to understand the molecular mechanisms of horizontal gene transfer leading to rapid adaptation of bacteria to pharmaceutical products.

Research Summary:
Selected Publications: 

- Woegerbauer M, Kuffner M, Domingues S, Nielsen KM. Involvement of aph(3’)-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments. Front. Microbiol. 2015. 6:442. IF=3.989

- Domingues S, Da Silva GJ, Nielsen KM. Global dissemination patterns of common gene cassette arrays in class 1 integrons. Microbiol-SGM. 2015. 161:1313–1337. IF=2.557

- Domingues S, Toleman MA, Nielsen KM, Da Silva GJ. Identical Miniature Inverted Repeat Transposable Elements (MITE) flanks class 1 integrons in clinical isolates of Acinetobacter spp. J. Clin. Microbiol. 2013. 51:2382-2384. IF=3.993

- Domingues S, Harms K, Fricke WF, Johnsen PJ, Da Silva GJ, Nielsen KM. Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species. PLoS Pathog. 2012. 8(8): e1002837. IF=7.562

- Domingues S, Nielsen KM, Da Silva GJ. The blaIMP-5-carrying integron in a clinical Acinetobacter baumannii strain is flanked by miniature inverted-repeat transposable elements (MITEs). J. Antimicrob. Chemother. 2011. 66:2267-2680. IF=5.313

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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