Ana Maria Cardoso (Cardoso AMC)
239 820 190
ana.cardoso@cnc.uc.pt
Pos-Doc
Group at CNC
Education: 

Ana Maria Cardoso graduated in Biochemistry from the University of Coimbra (UC) in 2009. In 2010 she received a Ph.D scholarship from the Portuguese Science Foundation (FCT) and initiated her Ph.D under the supervision of Prof. Dr Maria Amália Jurado and Prof Dr Maria da Conceição Pedroso de Lima at the Biochemistry Department of UC. Between 2010 and 2014 she worked in the development of surfactant-, peptide-, and polymer-based nanoparticles for plasmid DNA and siRNA delivery to tumor cells. Ana Maria Cardoso obtained her Ph.D. degree in Biosciences, specialization in Biochemistry, from the University of Coimbra in 2014. In 2015 Ana Maria Cardoso integrated the Center  for Neuroscience and Cell Biology (CNC) as a PosDoc. Since 2009, Ana Maria Cardoso hás published 2 book chapters and 16 papers in international peer-reviewed journals, with over 170 citations, which resulted in an h-index of 9.

Afiliation: 

CNC

Area of Research: 

My line of research hás been dedicated to the development of surfactant-, peptide-, and polymer-based nucleic acid delivery systems for gene therapy. In the context of my M.Sc. and Ph.D. degrees, I studied the ability of nanoparticles produced from these compounds to mediate efficient siRNA and DNA internalization and the consequent modulation of their molecular targets. In parallel, aiming at identifying the properties and mechanisms underlying the good performance of non-viral vectors, I performed biophysical studies of the developed delivery systems and their interactions with biological membranes and model membranes.  
Currently, my investigation focuses on the development of strategies to improve cancer (glioblastoma) susceptibility to chemotherapeutic agents. The work in process aims at selecting non-coding RNAs whose targets are involved in pathways of the energy metabolism, to normalize the balance between different pathways of energy production (glycolysis and oxidative phosphorylation). The modulation of these pathways towards mitochondria-dependent mechanisms, and concomitant administration of mitochondria-targeting chemotherapeutic drugs, will facilitate tumor cell elimination.

Research Summary: 
orcid.org/0000-0002-1629-4782
Selected Publications: 

1-    Ana M.S. Cardoso, Sara Trabulo, Ana L. Cardoso, Annely Lorents, Catarina M. Morais, Paula Gomes, Cláudia Nunes, Marlene Lúcio, Salette Reis, Kärt Padari, Margus Pooga, Maria C. Pedroso de Lima, Amália S. Jurado. “S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization”, Biochimica et Biophysica Acta 1818 (2012) 877–888. (Impact Factor 3.84)

2-    Ana M. Cardoso, Sara Trabulo, Ana L. Cardoso, Sílvia Maia, Paula Gomes, Amália S. Jurado, and Maria C. Pedroso de Lima. “Comparison of the Efficiency of Complexes Based on S413-PV Cell-Penetrating Peptides in Plasmid DNA and siRNA Delivery”, Molecular Pharmaceutics 10 (2013) 2653−2666. (Impact Factor 4.38)

3-    Ana M. Cardoso, Catarina M. Morais, Sandra G. Silva, Eduardo F. Marques, Maria C. Pedroso de Lima and Maria Amália S. Jurado. “Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions”, International Journal of Pharmaceutics 474 (2014) 57-69 (Impact Factor 3.65)

4-    Ana M. Cardoso, Catarina M. Morais, Sandra G. Silva, M. Luísa do Vale, Eduardo F. Marques, Maria C. Pedroso de Lima and Amália S. Jurado. “New Serine-derived Gemini surfactants as gene delivery systems”, European Journal of Pharmaceutics and Biopharmaceutics 89 (2015) 347-356 (Impact Factor 3.85)

5-    Ana M. Cardoso, Catarina M. Morais, A. Rita Cruz, Sandra G. Silva, M. Luísa do Vale, Eduardo F. Marques, Maria C. Pedroso de Lima and Amália S. Jurado, “Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression”, Molecular Pharmaceutics 12 (2015) 716-730 (Impact Factor 4.38)

 
   
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