Ana I. Duarte
239 820 190
PhD Fellow
Group at CNC

2007: PhD in Biology (Cell Biology), Faculty of Sciences and Technology (FCTUC), University of Coimbra (UC), Portugal;

2002: MSc in Cell Biology, FCTUC;

1998: Licenciate in Biology (Research Speciality), FCTUC;

2015-2016: Visiting Researcher, Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Medical School, Lund University, Lund, Sweden;

2008-2009: Visiting Researcher, Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Medical School, Lund University, Lund, Sweden.



Area of Research: 

Role of metabolic hormones and their intracellular signaling pathways in loss of cellular homeostasis and cognitive function associated with chronic diabetes, aging and neurodegenerative disorders (Alzheimer and Huntington diseases).
Effect of anti-diabetic therapies on brain degeneration upon aging and chronic diabetes.

Research Summary: 
Selected Publications: 

(5 most relevant original papers, selected amongst 1 book, 2 book chapters, 39 papers in international peer-reviewed journals, 3 papers in national peer-reviewed journals, 51 papers in conference proceeding, 15 invited communications, 34 oral communications and 104 posters):

- Duarte AI, Petit G, Ranganathan S, Li J-Y, Oliveira CR, Brundin P, Björkqvist M, Rego AC (2011). Protection by IGF-1 against diabetic features in Huntington’s disease R6/2 mice model. Exp Neurol 231: 314-319. (IF: 4.436).

- Duarte AI, Santos P, Oliveira CR, Santos MS, Rego AC (2008). Insulin neuroprotection against  signalling pathways and changes upon oxidative stress is mediated by Akt and GSK-3 in protein expression. Biochem Biophys Acta – Mol Cell Res 1783: 994-1002. (IF: 5.392).

- Duarte AI, Proença T, Santos MS, Oliveira CR, Rego AC (2006). Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes 55: 2863-2870. (IF: 8.261).

- Duarte AI, Santos MS, Oliveira CR, Rego AC (2005). Insulin neuroprotection against oxidative stress in cultured cortical neurons – involvement of uric acid and glutathione antioxidant defenses. Free Radic Biol Med. 39: 876-889. (IF: 5.632).

- Duarte AI, Santos MS, Seiça R, Oliveira CR (2004). Oxidative stress affects synaptosomal GABA and glutamate transport in diabetic rats: the role of insulin. Diabetes 53: 2110-2116. (IF: 8.261).

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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