Rosa Maria Branco de Matos Costa Resende
Post-doc fellow
Group at CNC

Rosa Resende holds a BSc in Biology, a MSc in Cell Biology and a PhD in Biomedical Sciences by the University of Coimbra. As a PhD student she did a scientific internship in the laboratory of Professor J. Busciglio, University of California, Irvine, USA, where she had the opportunity to study mitochondrial function and intracellular trafficking in an in vivo model of Alzheimer’s disease (the 3xtg-AD mice). Currently, she is Post-doc fellow for the Foundation for Science and Technology (FCT) developing research work in the Cell Metabolism and Quality Control Group at the Center for Neurosciences and Cell Biology (CNC) under the supervision of Doctor Cláudia Pereira and Doctor Armanda Santos. She is author/co-author of 18 peer-reviewed papers with an h factor of 11 and 729 citations, and of one book chapter. She has been supervisor of Scientific Training of undergraduate students in Biochemistry (FCTUC) and co-supervisor of one Master student. As a post-doc she has also been designated as laboratory tutor of two Master students and tutor of laboratory practical’s in collaboration with the PhD Programme at the CNC on Experimental Biology and Biomedicine (PDBEB), with the Master in Cell Biology of Faculty of Science and Technology and with the Master Course in Biomedical Research and Integrated Master in Medicine, Faculty of Medicine, UC. She has also been a collaborator in the “Neurobiology I” subject of the Master in Biomedical Engineering from Faculty of Science and Technology, UC. Since 2004 she has taken part in science communication activities such as the “Brain Awareness Week”, Ciência Viva – ocupação científica dos jovens nas férias” and “Portuguese Science and Technology Week”.



Area of Research: 

She is interested in understanding the molecular mechanisms involved in neurodegenerative diseases in particular Alzheimer´s disease focusing the endoplasmic reticulum (ER) stress. Several features of neuroinflammation have been detected in AD patients, supporting an inflammatory hypothesis. Currently, she is interested in to investigate the inflammasome as a potential sensor of sustained ER stress triggered by Aβ peptide in microglia. In parallel, she has been working on a project aimed at developing a new inhibitor of BACE1, a key enzyme for Aβ peptide formation.

Research Summary:
Selected Publications: 

Valente J*, Resende R*, Zuzarte M, Gonçalves MJ, Lopes MC, Cavaleiro C, Pereira C, Salgueiro L, Cruz MT. (2015) Bioactivity and safety profile of Daucus carota subsp. maximus essential oil. Industrial Crops and Products. 77:218-224. IF(2014): 2.837
*these authors contributed equally

Gomes S, Martins I, Fonseca AC, Oliveira CR, Resende R*, Pereira CMF. (2014) Protective effect of leptin and ghrelin against toxicity induced by amyloid-β oligomers in a hypothalamic cell line. J. Neuroendocrinol.  26: 176-185. IF (2014): 4.058
*Corresponding author

Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CMF. (2012) Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers.  Aging Cell. 11(5):823-33.
IF(2012): 6.265

Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) Neurotoxic effect of oligomeric and fibrillar species of Aß1-42 peptide. Involvement of ER calcium release in oligomers-induced cell death. Neuroscience 155:725-737. IF(2008): 3.556

Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR. (2008) Brain oxidative stress in a triple transgenic mouse model of Alzheimer’s disease. Free Radic. Biol. Med. 44, 2051-2057.
IF(2008): 5.399

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

© 2019 CNC - Center for Neuroscience and Cell Biology
powered by DigitalWind