Joana Guedes (Guedes, J. R.)
239 820 190
joana.guedes@cnc.uc.pt
Post-doc researcher
Group at CNC
Education: 

Joana Guedes obtained her MSc degree in Biochemistry from the University of Coimbra, after which, in 2011, she enrolled in the Doctoral Programme in Experimental Biology and Biomedicine coordinated by the Center for Neuroscience and Cell Biology (CNC) of the same university, pursuing her PhD in the Vectors and Gene Therapy, under supervision of Dr. Ana Luísa Cardoso and Dr. Maria Conceição Pedroso de Lima. She studied the behavior of microglia and monocytes in Alzheimer’s disease, both in animal models and in humans, and the contribution of miRNA deregulation to myeloid cells phenotypes. Also during her PhD, she moved to Boston to work in the Neuroimmunology and Innate Immunity Laboratory of the Center for Immunology and Inflammatory Diseases at the Massachusetts General Hospital lead by Dr. Joseph El Khoury. In this group, she studied the therapeutic contribution of the injection of bone-marrow derived monocytes to the decrease of Aβ deposits in the brain of a mouse model of Alzheimer’s disease. Currently, she is working in the Neuronal Circuits and Behaviour group at CNC.

Afiliation: 

CNC

Area of Research: 

At present, Joana Guedes main research interests are focused on the contribution of microglia for the formation, refinement and normal function of neuronal circuits in health and disease.

Research Summary: 
orcid.org/0000-0001-9054-1887
Selected Publications: 

Guedes, J.R., Custodia, C.M., Silva, R.J., et al. (2014). Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model. Hum Mol Genet, 23, 6286-6301. IF – 6.4 (doi: 10.1093/hmg/ddu348)

Guedes, J., Santana, I., Cunha, C., et al. (2016) MiRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 3, 7-17
(doi: 10.1016/j.dadm.2015.11.004)

Other information: 
 
   
© 2017 CNC - Center for Neuroscience and Cell Biology powered by ponto.C