Joana Guedes (Guedes, J. R.)
239 820 190
Post-doc researcher
Group at CNC

Joana Guedes obtained her MSc degree in Biochemistry from the University of Coimbra, after which, in 2011, she enrolled in the Doctoral Programme in Experimental Biology and Biomedicine coordinated by the Center for Neuroscience and Cell Biology (CNC) of the same university, pursuing her PhD in the Vectors and Gene Therapy, under supervision of Dr. Ana Luísa Cardoso and Dr. Maria Conceição Pedroso de Lima. She studied the behavior of microglia and monocytes in Alzheimer’s disease, both in animal models and in humans, and the contribution of miRNA deregulation to myeloid cells phenotypes. Also during her PhD, she moved to Boston to work in the Neuroimmunology and Innate Immunity Laboratory of the Center for Immunology and Inflammatory Diseases at the Massachusetts General Hospital lead by Dr. Joseph El Khoury. In this group, she studied the therapeutic contribution of the injection of bone-marrow derived monocytes to the decrease of Aβ deposits in the brain of a mouse model of Alzheimer’s disease. Currently, she is working in the Neuronal Circuits and Behaviour group at CNC.



Area of Research: 

At present, Joana Guedes main research interests are focused on the contribution of microglia for the formation, refinement and normal function of neuronal circuits in health and disease.

Research Summary:
Selected Publications: 

Guedes, J.R., Custodia, C.M., Silva, R.J., et al. (2014). Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model. Hum Mol Genet, 23, 6286-6301. IF – 6.4 (doi: 10.1093/hmg/ddu348)

Guedes, J., Santana, I., Cunha, C., et al. (2016) MiRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 3, 7-17
(doi: 10.1016/j.dadm.2015.11.004)

Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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