Ana Cristina Rego
+351 239820190
Assistant Professor with ‘Agregação’
Group at CNC

Ana Cristina Rego (Ph.D.) is tenure Assistant Professor since 1999, lecturing classes of Biochemistry, Neuroscience and Neurobiology, at the Faculty of Medicine, University of Coimbra (UC), where she initiated as Teaching Assistant in 1997 and received the 'Agregação' academic degree in 2010. She is also head of the research group ‘Mitochondrial Dysfunction and Signaling in Neurodegeneration’ at the CNC-Center for Neuroscience and Cell Biology (CNC), at UC, since 2003. AC Rego received the Master in Cell Biology in 1994 and the Ph.D. in Cell Biology in 1999 at UC, under the supervision of Prof. Catarina R. Oliveira, and was postdoctoral researcher and visiting scientist in the lab of Prof. David G. Nicholls, at the University of Dundee, Scotland, UK, and at the Buck Institute, Novato, CA, USA, from 1998-2000. In 2004 and 2005 AC Rego was the coordinator of the BEB PhD Programme at CNC. AC Rego investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Huntington’s and Alzheimer’s diseases, focusing on glutamatergic postsynaptic dysfunction, the role of lysine deacetylases on mitochondrial function, and modified neurogenesis. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, ‘Instituto de Investigação Interdisciplinar’ (IIIUC), Faculty of Medicine-UC, ‘Fundação para a Ciência e a Tecnologia’ (FCT) projects, and recently received two prizes from ‘Santa Casa da Misericórdia de Lisboa’ (SCML), and ‘Fundação Luso Americana para o Desenvolvimento’ (FLAD). AC Rego holds an H factor of 33 and more than 3300 citations, published 94 original and review articles, 13 book chapters and more than 100 abstracts in research meetings, and is currently the Vice-President of the board of ‘Sociedade Portuguesa de Neurociências’ (SPN). AC Rego also supervised/co-supervised the work of several post-docs, 15 Ph.D. students and 25 Master students (concluded degrees).



Area of Research: 

Neurosciences; Mitochondria; Oxidative stress; Cell Signaling; Neurodegenerative disorders

Research Summary:
Selected Publications: 

Mota S. I., Costa R. O., Ferreira I. L., Santana I., Caldeira G. L., Padovano C., Fonseca A. C., Baldeiras I., Cunha C., Letra L., Oliveira C. R., Pereira C. M., Rego A. C. (2015) Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease. Biochim. Biophys. Acta - Molecular Basis of Disease 1852, 1428-1441.

Silva A., Naia L., Dominguez A., Ribeiro M., Rodrigues J., Vieira O. V., Lessmann V., Rego A. C. (2015) Overexpression of BDNF and full-lengthTrkB receptor ameliorate striatal neural survival in Huntington’s disease. Neurodegener. Dis. 15, 207-218.

Nunes J. B., Peixoto J., Soares P., Maximo V., Carvalho S., Pinho S., Vieira A., Paredes J., Rego A. C., Ferreira I. L., Gomez-Lazaro M., Sobrinho-Simoes M., Singh K. K., Lima J. (2015) OXPHOS dysfunction regulates integrin-β1 modifications and enhances cell motility and migration. Hum. Molec. Genet. 24, 1977-1990.

Ferreira I. L., Ferreiro E., Schmidt J., Cardoso J. M., Pereira C. M., Carvalho A. L., Oliveira C. R., Rego A. C. (2015) A and NMDAR activation cause mitochondrial dysfunction involving ER calcium release. Neurobiol. Aging 36, 680-692.

Naia L., Ferreira I. L., Cunha-Oliveira T., Duarte A. I., Ribeiro M., Rosenstock T. R., Laço M. N., Ribeiro M. J., Oliveira C. R., Saudou F., Humbert S., Rego A. C. (2015) Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington’s disease human lymphoblasts. Mol. Neurobiol. 51, 331-348.

Other information: 
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