Ana Catarina RG Fonseca
Group at CNC

Degree in Biological Anthropology.
MSc in Cellular Biology studying the neuroprotective effect of statins in Alzheimer's disease.
PhD in Molecular Biology studying the alterations in proteostasis in brain microvascular endothelial cells in Alzheimer's disease.




Area of Research: 

Glucocorticoids and immunosuppressive agents as new tools for discovery of novel mechanisms and therapeutic principles in insulin resistance

Research Summary:
Selected Publications: 

•    Fonseca, AC; Moreira, P; Oliveira, CR; Cardoso, SM; Pinton, P; Pereira, CF (2015) Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells. Molecular Neurobiology. 51 (2): 610-622. DOI: 10.1007/s12035-014-8740-7. Impact factor:5.29
•    Fonseca, AC; Cardoso, SM; Pereira, CF (2014) Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum. Therapeutic Targets for Neurological Diseases. 2 (1): e428. DOI: 10.14800/ttnd.428
•    Fonseca, AC; Oliveira, CR; Pereira, CF; Cardoso, SM (2014) Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843 (6):1150-1161. DOI: 10.1016/j.bbamcr.2014.02.016. Impact factor: 4.66
•    Fonseca, AC; Ferreiro, E; Oliveira, CR; Cardoso, SM; Pereira, CF (2013) Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832 (12): 2191-2203. DOI: 10.1016/j.bbadis.2013.08.007. Impact factor: 4.66
•    Fonseca AC, Resende R, Oliveira C, Pereira C (2010) Cholesterol and statins in Alzheimer’s disease: current controversies. Experimental Neurology 223: 282-293. DOI: 10.1016/j.expneurol.2009.09.013. Impact factor: 4.62

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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