Ana Burgeiro
(+351) 239 820 190
Post-doctoral fellow
Group at CNC

I completed a degree in Biology - Scientific Branch, at the Faculty of Science and Technology, University of Coimbra (FCTUC) in 2006. Immediately, I started my PhD in Cell Biology, also at the Faculty of Science and Technology, University of Coimbra (FCTUC), which I finished in 2011.
During my PhD, I reached the two major objectives initially set. The first objective was to understand the potential cytotoxic effect of 2 synthetic compounds – edelfosine and perifosine – and 2 phytochemicals – berberine and sanguinarine – in melanoma cell lines. The second objective was focused on the impact of edelfosine and perifosine in mitochondrial fractions isolated from mouse liver..
In my first post-doc (2011-2012), the main objective was to determine whether treatment with doxorubicin (DOX) had adverse effects on cardiac hemodynamic function by inducing mitochondrial dysfunction.
In my second post-doc (2012-2013), the main objective was to characterize metabolically, as well as physiologically, two very distinct adipose tissue depots, subcutaneous and epicardial adipose tissue (SAT and EAT) from patients with heart failure (HF), with or without diabetes.
Actually (2014-present), the main objective of my third post-doc is to identify possible markers and mechanisms involved in the development and healing of diabetic ulcers in first-degree relatives of type 2 diabetic patients with and without diabetic ulcers.



Area of Research: 

Diabetes mellitus is expected to rise to 592 million people by 2035. Diabetic foot ulceration (DFU) is a serious complication in 15% of diabetics, with 84% of those receiving lower leg amputations. In order to improve the prevention and treatment of DFU, we will analyze serum and skin biopsies of people with type 2 diabetes, with and without DFU.
To understand if possible markers involved in the development of the DFU are hereditary, we will also study the family members of diabetic people, with and without a history of DFU. We will assess expression levels of genes and proteins involved in inflammation, such as important growth and angiogenic factors, as well as neuropeptides and their receptors, which are involved with the mechanisms of wound healing in diabetes. Through the identification and characterization of these mechanisms, we will contribute to new therapeutic strategies, improving the regeneration of diabetic wounds and the health and quality of life of these patients.


Research Summary: 
ORCID iD 0000-0001-8467-3840
Selected Publications: 

1.    Carvalho FS, Burgeiro A, Garcia R, Moreno AJ, Carvalho RA, Oliveira PJ (2014) Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Medicinal Research Reviews; 34(1), pp 106-35. IF – 8.226 (2015)
2.    Burgeiro A, Mollinedo F, Oliveira PJ (2013) Ipilimumab and Vemurafenib: Two Different Roads to Antagonize Melanoma Survival. Current Cancer Drug Targets; 13(8), pp 879-94. IF – 3.522 (2014)
3.    Burgeiro A, Bento AC, Gajate C, Oliveira PJ, Mollinedo F (2013) Rapid human melanoma cell death induced by sanguinarine through oxidative stress. European Journal of Pharmacology; 705(1-3), pp 109-18. IF – 2.532 (2014)
4.    Burgeiro A, Pereira CV, Carvalho FS, Pereira GC, Mollinedo F, Oliveira PJ (2013) Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce permeability transition. Mitochondrion; 13(1), pp 25-35. IF – 3.249 (2014)
5.    Burgeiro A, Gajate C, Dakir el H, Villa-Pulgarín JA, Oliveira PJ, Mollinedo F (2011) Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. Anticancer Drugs; 22(6), pp 507-18. IF – 1.784 (2014)


Other information:

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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