Ermelindo C Leal
Postdoctoral Fellow
Group at CNC

Ermelindo Leal is currently a postdoctoral fellow at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. Previously, he was a Research Fellow at Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, US. Ermelindo received his PhD from the University of Coimbra, Faculty of Sciences and Technology, Coimbra, Portugal. In his PhD, he enrolled in the PhD Programme in Experimental Biology and Biomedicine at CNC, and his thesis work was done at the Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, and at the Department of Ophthalmology of the Institute of Medical Sciences, University of Aberdeen, Scotland. He has also been the principal investigator and co-investigator of competitively funded projects from the Portuguese Foundation for Science and Technology (FCT) and the European Association for the Study of Diabetes (EASD), and he participated in projects in collaboration with pharmaceutical companies. Most of his publications in peer-reviewed journals are in the top quartile of their area. Moreover, Ermelindo has an extensive number of communications in national and international meetings and supervise undergraduate and postgraduate students.



Area of Research: 

Study the role of neuropeptides in diabetic wound healing. Develop biomaterials for an efficient neuropeptide and cell delivery into the wound. Unveil the role of the endocannabinoid system in the skin. Evaluate the modulation of the endocannabinoid system as therapeutic strategy for diabetic foot ulcers. Promote the function of diabetic endothelial progenitor cells to improve chronic diabetic ulcers. Study novel therapies for the treatment of impaired diabetic wound healing. Development of an in vitro 3D skin culture model for wound healing.

Research Summary:
Selected Publications: 

1.    Leal EC, Carvalho E, Tellechea A, Kafanas A, Tecilazich F, Kearney C, Kuchibhotla S, Auster ME, Kokkotou E, Mooney DJ, LoGerfo FW, Pradhan-Nabzdyk L, Veves A. Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol. 2015 Jun;185(6):1638-48. IF 4.6
2.    Moura LI, Dias A, Suesca E, Casadiegos S, Leal EC, Fontanilla MR, Carvalho L, de Sousa HC, Carvalho E. Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Biochim Biophys Acta. 2014 Jan;1842(1):32-43.IF 4.66
3.    Moura LI, Dias A, Leal EC, Sousa H, Carvalho E. Chitosan-based dressings loaded with neurotensin – an efficient strategy to improve early diabetic wound healing. Acta Biomater. 2014 Feb;10(2):843-57. IF 5.68
4.    Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal EC, Tellechea A, Pradhan L, Lyons TE, Giurini JM, Veves A. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012 Nov;61(11):2937-47. IF 8.47
5.    Leal EC, Martins J, Voabil P, Liberal J, Chiavaroli C, Bauer J, Cunha-Vaz J, Ambrósio AF. Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes. 2010 Oct; 59(10):2637-45. IF 8.47

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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