Pedro Gomes
Group at CNC

Pedro Gomes obtained his degree in Biological Engineering at the University of Minho, Portugal and his PhD in Human Biology at the Faculty of Medicine of University of Porto under the supervision of Prof. Patrício Soares da Silva and Prof. Pedro A. Jose (Georgetown University, USA). He then pursued postdoctoral studies, having studied the regulation of ion channels by tyrosine phosphorylation (UCLA School of Medicine, USA), cellular and molecular mechanisms underlying aging, using the budding yeast Saccharomyces cerevisiae as a model system (School of Health Sciences, University of Minho), and mechanisms underlying the pathogenesis of hypertension in the context of aging using cellular and animal models (Faculty of Medicine, University of Porto). He was subsequently hired as Assistant Researcher under the Programa Ciência 2007, and continued his research on hypertension and later expanded to the field of sirtuins. More recently, he joined the Center for Neuroscience and Cell Biology of University of Coimbra (CNC) as Assistant Researcher, and devoted his studies to the role that sirtuin member SIRT2 might play in regulating insulin sensitivity in specific organs (liver and brain) under normal and diabetogenic conditions. As the result of his participation in several research projects and also his training in different institutions, he has acquired a multidisciplinary background in areas with biological and clinical relevance. He has also experience in supervising undergraduate as well as graduate students and published 40 articles in international journals.



Area of Research: 

Role of sirtuins in metabolic disorders; molecular mechanisms of aging and age-related diseases

Research Summary:
Selected Publications: 

1 - Emerging role of Sirtuin 2 in the regulation of mammalian metabolism. Gomes P*, Outeiro TF, Cavadas C. Trends Pharmacol Sci, 2015 (in press) (* corresponding author) (IF 11.539)
2 - Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased cJun NH2 terminal kinase activation. Gomes P* et al. Free Radic Biol Med, 2013 (* corresponding author) (IF 5.271)
3 - Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar Kyoto rats: a comparison with SHR. Pinto V, (…), Gomes P, Soares-da-Silva P. Exp Gerontol, 2012 (IF 3.911)
4 - Identification of a functional interaction between Kv4.3 channels and c-Src tyrosine kinase. Gomes P* et al. Biochim Biophys Acta, 2008 (* corresponding author) (IF 4.893)
5 - Low auxotrophy complementing amino acid concentrations reduce yeast chronological life span. Gomes P et al. Mech Ageing Dev, 2007 (IF 4.308)

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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