Rita Perfeito
+351 239820190
Post-doctoral investigator
Group at CNC

Rita Perfeito got a degree in Biology in 2005, from the Faculty of Sciences and Technology of the University of Coimbra, Portugal. In 2006, Rita received a fellowship from FCT to develop her PhD thesis entitled Interplay between alpha-synuclein and oxidative stress in Parkinson’s disease cell models, under the supervision of Professor Ana Cristina Rego from the Mitochondrial Dysfunction and Signalling in Neurodegeneration group, at CNC. Between 2010 and 2012, Rita worked as a Research Technician in the group of Prof. Ana Cristina Rego and in the meanwhile, got her PhD in Cell Biology, from the University of Coimbra, Coimbra, Portugal. During this time, Rita has presented her work in several national and international meetings in the scientific area (oral and poster communications) and was selected to receive a travel grant to participate at the FENS Forum 2008.
Rita Perfeito has been working as a post-doctoral researcher in the Vectors and Gene Therapy group, Center for Neuroscience and Cell Biology, Coimbra, Portugal, since March 2014, under the supervision of Professor Luís Pereira de Almeida. She was recently awarded a post-doctoral grant by FCT (SFRH/BPD/100130/2014), with the project Role and mechanisms of alpha-synuclein spreading in Parkinson’s disease, which aims to identify the mechanisms of alpha-synuclein dissemination/migration in Parkinson’s disease using in vitro and in vivo models of this disorder.



Area of Research: 

Neuroscience and Neurodegenerative disorders. Mechanisms underlying alpha-synuclein spreading in in vitro and in vivo models of Parkinson’s disease (PD); exosomes, other extracellular vesicles and autophagy mechanisms associated to PD.

Research Summary: 
Selected Publications: 

Rita Perfeito, Márcio Ribeiro, Tatiana Rosenstock, A. Cristina Rego (2015) Alpha-synuclein-induced oxidative stress correlated with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells. Submitted

Rita Perfeito, Diana F. Lázaro, Tiago F. Outeiro, A. Cristina Rego (2014) Linking alpha-synuclein aggregation and phosphorylation to the formation of reactive oxygen species in SH-SY5Y cells. Mol Cell Neurosci. 62C: 51-59. DOI: 10.1016/j.mcn.2014.08.002. Impact factor: 3.840 (2014)

Rita Perfeito, Teresa Cunha-Oliveira, A. Cristina Rego (2013) Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson’s disease – resemblance to the effect of amphetamine drugs of abuse. Free Rad Bio Med, 62: 186-201; special issue - Neurodegeneration.
DOI: 10.1016/j.freeradbiomed.2013.05.042
Impact factor: 5.271 (2013)

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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