Isabel Onofre
+351 239 820 190
isabel.onofre@cnc.uc.pt
PhD student
Group at CNC
Afiliation: 

CNC

Area of Research: 

Neurodegenerative diseases, in vitro disease models, induced pluripotent stem cells, cell reprogramming

Research Summary: 
http://orcid.org/0000-0002-4937-448X
Selected Publications: 

Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Déglon, Nicole;
Pereira de Almeida, Luís; Opal, Puneet. RNA Interference Mitigates Motor and Neuropathological
Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease. PLoS ONE, v. 9, n. 8, p. e100086-
e100086, 2014.

Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu;
Déglon, Nicole; de Almeida, Luís Pereira; Chiesa, Roberto. Silencing Mutant Ataxin-3 Rescues Motor
Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice. PLoS ONE, v. 8, n. 1, p.
e52396-e52396, 2013.

Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição,
Mariana; Déglon, Nicole; de Almeida, Luís Pereira. Overexpression of Mutant Ataxin-3 in Mouse
Cerebellum Induces Ataxia and Cerebellar Neuropathology. The Cerebellum, v. 12, n. 4, p. 441-455,2012.

Nascimento-Ferreira, I.; Santos-Ferreira, T.; Sousa-Ferreira, L.; Auregan, G.; Onofre, I.; Alves, S.;Dufour, N.; Colomer Gould, V. F.; Koeppen, A.; Deglon, N.; Pereira de Almeida, L. Overexpression ofthe autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Brain,v. 134, n. 5, p. 1400-1415, 2011.

 
   
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