Catarina Sofia Oliveira Miranda
+351 239 820 190
Pos-doc researcher
Group at CNC

Catarina Miranda has been developing research within the field of stem cell therapy in neurodegenerative disorders.
Catarina Miranda did her PhD at the Institute of Molecular and Cellular Biology of Porto, group of Doctor Monica Sousa, on the subject of Nervous system regeneration with mesenchymal stem cells (MSCs). Catarina became expert in this subject and produced substantial amount of work that resulted in several manuscripts as first author, published in the journals Stem Cells, Neurobiology of Disease, and Cell Transplantation: The Regenerative Medicine Journal. This work has won several prizes: best oral communication awarded by the Sociedade Portuguesa de Doenças Metabólicas (SPDM) in 2007; best poster conferred by the I3S IBMC/INEB/IPATIMUP Together in Science in 2010; best poster bestwoned by in the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) in 2010; she also won the Funds for junior investigators award to participate in the Gordon Research Conference (GRC) on Myelin in 2010; finally, this work was Cover in Stem Cells Journal (November 2011, volume 29, Issue 11, in 2011).
In May of 2012 Catarina joined as a post-doc the Vectors and Therapy group at the Center for Neuroscience and Cell Biology at the University of Coimbra, Portugal, where she has been developing a project on MSCs for therapy of Machado-Joseph disease. This project has huge clinical relevance for therapy of Machado-Joseph disease as well as other ataxias and she has accomplished very promising results, which will be published soon. In the meanwhile, Catarina has been participating in both national and international scientific meetings, which reveals the high quality of the work she has been developing. Catarina has substantial expertise on the field of MSCs, which coupled to the expertise of the group in Machado-Joseph disease, creates unique conditions for the success of her project.



Area of Research: 

Stem Cell Biology, Neurodegenerative Cerebellar Disorders, Cellular and Gene Therapies

Research Summary:
Selected Publications: 

Teixeira CA*, Miranda CO*, Sousa VF*, Santos TE, Malheiro AR, Solomon M, Maegawa G, Brites P and Sousa MM (2013). Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease. Neurobiology of Disease 2014 Jun;66:92-103. doi: 10.1016/j.nbd.2014.02.012. Epub 2014 Mar 6.
*Authors have contributed equally to this work.
IF: 5.078 (ISI)

Miranda CO, Teixeira CA, Sousa VF, Santos TE, Liz MA, Marques AM, Pinto-do-Ó P and Sousa MM (2014). Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice. Cell Transplantation: The Regenerative Medicine Journal 2014;23(2):239-52.
 doi:10.3727/096368913X669752. Epub 2013 Jun 27
IF: 3.570 (ISI)

Sá R, Miranda C, Leite C, Malheiro I, Carvalho F, Silva J, Barros A, Sousa M (2012). Biomarkers Expression in Human Seminiferous Epithelium. Microscopy and Microanalysis 18 (Suppl 5). Epub 2012 Sep 28. doi:10.1017/S1431927612012731.
IF: 2.495

Miranda CO, Brites P, Sousa MM and Teixeira CA (2013). Advances and Pitfalls of Cell Therapy in Metabolic Leukodystrophies. Cell Transplantation: The Regenerative Medicine Journal 22(2):189-204. Epub 2012 Sep 21. doi: 10.3727/096368912X656117.
IF: 3.570 (ISI)

Miranda CO*, Teixeira CA*, Liz MA, Sousa VF, Franquinho F, Forte G, di Nardo P, Pinto-do OP, Sousa MM (2011) Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Diminishes Neuropathology in a Mouse Model of Krabbe's Disease. Stem Cells 29(11): 1738-1751. doi: 10.1002/stem.724.
*Authors have contributed equally to this work.
IF: 7.781 (ISI)

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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