Ana Teresa Simões (Simões AT)
+351 239820190
Group at CNC

Ana Teresa Antunes Simões got her PharmD in Pharmaceutical Sciences by the Faculty of Pharmacy of Coimbra in 2007. She was distinguished with Lusitana Pharmaceutical Society award in the same year, which honors the best student concluding the course in each national faculty. In 2012, she got her PhD in Pharmaceutical Biotechnology, with distinction and honors, approved unanimously, by the Faculty of Pharmacy of Coimbra with the thesis “Calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease”, under the supervision of Luís Pereira de Almeida. She is currently Post-Doc at the Center for Neuroscience and Cell Biology of Coimbra.



Area of Research: 

My current research interest relies on the study of Machado-Joseph disease, also known as Spinocerebellar Ataxia type 3. My objective is to study proteolysis as a pathogenic mechanism and its inhibition as a therapeutic strategy.

Research Summary:
Selected Publications: 

Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WFA, Cavadas C*, Pereira de Almeida L*. Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease. Hum Mol Genet. 2015 doi: 10.1093/hmg/ddv271 *equally contributed (IF:6.4)

Simões AT, Gonçalves N, Nobre RJ, Duarte CB, Pereira de Almeida L. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease. Hum Mol Genet. 2014 Sep; 23(18):4932-44. (IF:6.4)

Gonçalves N, Simões AT, Cunha RA, de Almeida LP. Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. Ann Neurol. 2013 May; 73(5):655-66 (featured article award 2014, SPN) (IF:10)

Simões AT, Gonçalves N, Koeppen A, Déglon N, Kügler S, Duarte CB, Pereira de Almeida L. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin-3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease. Brain. 2012 Aug; 135(Pt 8):2428-39 (featured article award 2013, SPN) (IF:9.2)

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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