Ana Cristina Vasconcelos-Ferreira
PhD Student
Group at CNC

Ana Cristina graduated in 2010 in Genetics and Biotechnology in University of Trá-Os-Montes e Alto Douro, which enabled to develop competences in several areas such as in Biotechnology, Cellular and Human Genetics, among others. She was the recipient of a scholarship for the Integration in Scientific Research (BII) "Application of the Omics to traceability of Agro-food products" funded by FCT, developed at the Center for Genetics and Biotechnology/IBB at the University of Trás-Os-Montes e Alto Douro, which allowed to develop the interest in Scientific Research.
In 2010 she started her master in Pharmaceutical Biotechnology at the Faculty of Pharmacy of the University of Coimbra. During the master project she started to work with a CAG triplet repeats disorder at Center for Neuroscience and Cell Biology (CNC) in the Vectors and Gene therapy group and she found this area very exciting.
Currently, she is PhD student in the same research group, with a fellowship from the Portuguese Foundation for Science and Technology. (FCT).



Area of Research: 

The main research field of Ana is the study of the Autophagy pathway in Machado Joseph disease as possible underlying pathological mechanism and also as potential target to develop therapeutics to this devastating neurodegenerative disorder.

Research Summary:
Selected Publications: 

Isabel Nascimento-Ferreira, Clévio Nóbrega, Ana Vasconcelos-Ferreira, Isabel Onofre, David Albuquerque, Célia Aveleira, Hirokazu Hirai; Nicole Déglon, Luís Pereira de Almeida. Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Brain 2013. In Press

Clévio Nóbrega, Sara Carmo-Silva, David Alburquerque, Ana Vasconcelos-Ferreira, Udaya-GeethaVijayakumar, Liliana Mendonça, Hirokazu Hirai, Luís Pereira de Almeida. Reestablishing Ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease. Brain 2015. Accepted
5 year impact factor: 10.418

Other information: 

Project ERA-Net for Research Programmes on Rare Diseases: “Towards the understanding of pathological protein processing and toxicity in Machado-Joseph Disease”

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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