João Ramalho-Santos
+351 239855760
PI and Director (CNC), Associate Professor, FCTUC
Group at CNC


Area of Research: 

Biology of Reproduction
-Metabolic characterization of spermatogenesis and gamete function in mammals
-Detailed characterization of human sperm function and how it can be modulated (by drugs, endocrine disruptors, spermicides, etc.)
-Novel methodologies for evaluation of human gamete quality and their application in Assisted Reproduction
-Cell and metabolic alterations in reproductive tissues under conditions such as age and diabetes

Stem Cell Biology
- Metabolic cues involved in the maintenance, diferentiation and reprogramming of pluripotent cells

Research Summary:
Selected Publications: 

Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency. Ana Sofia Rodrigues, Marcelo Correia, Andreia Gomes, Sandro L. Pereira, Tânia Perestrelo, Maria Inês Sousa & João Ramalho-Santos. PLoS ONE 10(7):e0131663. doi: 10.1371/journal.pone.0131663. 2015. Impact Factor-3.2. Q1 Multidisciplinary Sciences.

From gametogenesis and stem cells to cancer: Common metabolic themes. Sandro Pereira*, Ana Sofia Rodrigues*(*co-first authors), Maria Inês Sousa, Marcelo Correia, Tânia Perestrelo & João Ramalho-Santos. Human Reproduction Update 20:924-943. 2014. Impact Factor-8.7 Q1 Reproductive Sciences (Top Journal)

Human sperm tail proteome suggests new endogenous metabolic pathways. Alexandra Amaral, Judit Castillo, Josep Maria Estanyol, José Luís Ballescà, João Ramalho-Santos & Rafael Oliva. Molecular & Cellular Proteomics 12: 330-342. 2013. Impact Factor-7.4. Q1 Biochemical Research Methods

How can ethics relate to science? The case of stem cell research. Ana Sofia Carvalho & João Ramalho-Santos. European Journal of Human Genetics 21: 591-595. 2013. Impact Factor-4.4. Q1 Biochemistry and Molecular Biology, Genetics & Heredity

p,p’-DDE activates CatSper and compromises human sperm function at environmentally-relevant concentrations. Renata S. Tavares, Steven Mansell, Christopher L Barratt, Stuart M. Wilson, Stephen J. Publicover & João Ramalho-Santos . Human Reproduction 28: 3167-3177. 2013. Impact Factor-4.7 Q1 Developmental Biology, Obstetrics and Gynecology, Reproductive Biology

Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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