Renata S. Tavares
239 104 422
Postdoctoral fellow
Group at CNC

Renata S. Tavares graduated in Biology from the University of Aveiro in 2007 and by 2008 she has finished her master’s degree in Cellular and Molecular Biology from the Faculty of Sciences and Technology of the University of Coimbra, working on the discovery and validation of a reproducible, straightforward and rather cheap methodology to address sperm DNA/chromatin status, an important marker of sperm fertilizing potential (scientific supervision: Professor Dr João Ramalho-Santos). Without losing her interest in such matter, her short career has been, nevertheless, focused on the impact of endocrine-disrupting chemicals in reproductive health status, specifically on the putative non-genomic effects of environmentally-persistent and resistant to degradation organochlorine compounds, which have become the subject of her FCT PhD fellowship (SFRH/BD/46002/2008) started in 2009. She has collaborated with Dr Steve Publicover (University of Birmingham, UK), an expert in sperm physiology, and concluded her PhD in 2014 at the Faculty of Sciences and Technology of the University of Coimbra under the supervision of Professor João Ramalho-Santos.
She has also worked as a research fellow in CNC studying the role of Diabetes mellitus-associated hyperglycemia in male fertility (FCT project EXPL/BEX-BCM/0224/2012) and recently at the Institute of Biomedicine (University of Aveiro) where as a post-doctoral fellow she analyzed the role of Alzheimer’s precursor protein and particularly its processing product - Aβ peptide - in human spermatozoa (scientific guidance of Professor Dr Odete da Cruz e Silva; FCT project PTDC/BEX-BCM/0493/2012).
Since 2008 she has presented her work in several national and international conferences (11 oral and 15 poster communications) being also invited to speak at international meetings of the field. She has also participated in the organization of the "Workshop em Reprodução Assistida e Preservação da Fertilidade" held in University Hospitals of Coimbra in 2014 and in the “I Simpósio de Pós-Graduação em Biomedicina” at Institute of Biomedicine in mid-2015. Additionally, she actively participates in other activities, including “Ciência Viva” and “Researcher’s Night”.
She is currently the Study Director of an in vitro study for the pharmaceutical Innothera (Laboratoire INNOTECH) to test potential compounds acting as spermicides at CNC.



Area of Research: 

Male (in)fertility; spermatogenesis; sperm functionality; sperm DNA damage; reproductive health status and endocrine disruption; environmental endocrine-disrupting chemicals; contraception; spermicidal active agents.

Research Summary:
Selected Publications: 

Tavares R.S., Mansell S., Barratt C.L., Wilson S.M., Publicover S.J. & J. Ramalho-Santos (2013). p,p’-DDE activates CatSper and compromises human sperm function at environmentally-relevant concentrations. Human Reproduction, 28(12): 3167-3177. DOI: 10.1093/humrep/det372.  SJR: Q1 in Reproductive Medicine; Q1 in Obstetrics and Gynecology. Impact Factor: 4.585 (2013).
Tavares R.S., Amaral S., Paiva C., Baptista M. & J. Ramalho-Santos (2015). In vitro exposure to the organochlorine p,p’­DDE affects functional human sperm parameters. Chemosphere 120: 443-446. DOI:10.1016/j.chemosphere.2014.08.075. SJR: Q1 in Environmental Chemistry; Q1 in Chemistry (miscellaneous); Impact Factor: 3.340 (2014/15).

Tavares R.S., Escada-Rebelo S., Correia M., Mota P.C. & J. Ramalho-Santos (2016). The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm. Reproduction 151(1): R1-R13. DOI: 10.1530/REP-15-0355. SJR: Q1 in Reproductive Medicine; Q1 in Obstetrics and Gynecology; Q1 in Embryology; Q1 in Endocrinology; Impact Factor: 3.174 (2014/15).

Tavares R.S.*, Silva A.F.*, Almeida -Santos T., Sousa A.P. & J. Ramalho-Santos (2013). Evaluation of human sperm chromatin status after selection using a modified Diff-Quik stain indicates embryo quality and pregnancy outcomes following In Vitro Fertilization. Andrology, 1(6):830-837. DOI: 10.1111/j.2047-2927.2013.00127.x. *Co-first authorship. SJR: Q1 in Urology; Impact factor: 2.298 (2014).

Sousa A.P.*, Tavares R.S.*, Velez de la Calle J.F., Figueiredo H., Almeida V., Almeida-Santos T. & J. Ramalho-Santos (2009). Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status. Human Reproduction, 24 (1): 28-36. DOI: 10.1093/humrep/den365. *Co-first authorship. SJR: Q1 in Reproductive Medicine; Q1 in Obstetrics and Gynecology; Impact Factor: 3.859 (2009).

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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