Ana Luísa Cardoso (Cardoso ALC)
+ 351 239820190
uc41483@uc.pt
Investigator
Group at CNC
Education: 

Ana Luísa Cardoso graduated in Biochemistry from the University of Coimbra (UC) in 2004, being awarded a merit prize as one of the 3% top students of the Faculty for Science and Technology of UC. In the same year she received a Ph.D scholarship from the Portuguese Science Foundation (FCT) and initiated her Ph.D under the supervision of Prof. Dr. Conceição Pedroso de Lima at the Biochemistry Department of UC. Between 2004 and 2008 she worked in the development of lipid-based nanoparticles for siRNA delivery to the CNS, aiming at generating new therapeutic tools for treatment of acute brain lesion. Her Ph. D. project was performed in collaboration with Prof. Ernst Wagner and Dr. Carsten Culmsee, at the Faculty of Pharmacy of Ludwig-Maximillian University (LMU) and with Prof. Dr. Nikolaus PLesnila, at the  Institute for Stroke and Dementia Research (LMU)  in Munich, where she had the opportunity to develop research work during 2006 and 2007.  
Ana Luísa Cardoso obtained her Ph.D. degree in Biochemical Technology from the University of Coimbra in 2008. In 2009 Ana Luísa Cardoso integrated the Center for Neuroscience and Cell Biology (CNC) as a PosDoc, where she had the opportunity to develop research focusing on miRNA involvement in CNS diseases, including glioblastoma and Alzheimer’s disease. In 2012 she was awarded a grant from FCT to develop a new lentiviral-based platform to modulate miRNA levels in AD animal models, aiming at decreasing APP and BACE levels and improving neuronal deficits.
In 2013 Ana Luísa Cardoso was awarded a position as Invited Auxiliary Investigator at CNC. Since 2005, Ana Luísa Cardoso has published 4 book chapters and 27 papers in international peer-reviewed journals with over 629 citations, which resulted in an h-index of 13 and she has successfully supervised 8 Master students, 1 Ph.D. student and is currently supervising 3 Ph.D. students and 2 Master students.

Afiliation: 

CNC

Area of Research: 

Ana Luísa Cardoso research has been dedicated to investigation of miRNA contribution to neuroinflammation in aging, neurodegenerative and neurodevelopmental disorders, with a particular focus on Alzheimer’s disease (AD) and other dementias. Towards this purpose, Ana Luísa Cardoso makes use of both animal models of disease and human blood cells. The main goals of her research are to understand how miRNAs regulate innate immune, both systemically and locally, in the brain, and to develop new gene therapy tools that can be of use to the modulation of inflammation in a disease setting.

Research Summary: 
orcid.org/0000-0001-5145-4561
Selected Publications: 

P.M. Costa, A.L. Cardoso, C. Custódia, P. Cunha, L. Pereira de Almeida, M.C. Pedroso de Lima, “MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma”, Journal of Controlled  Release, 2015, 207, 31-39 (Impact factor 7.26)

J.R. Guedes, C.M. Custódia, R.J. Silva, L.P. de Almeida, M.C Pedroso de Lima, A.L. Cardoso, “Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model”, Hum Molecular Genet, 2014, 23 (23), 6286-6301 (Impact factor – 7.6)

P.M. Costa, A.L. Cardoso, C. Custódia, P. Cunha, L. Pereira de Almeida, M.C. Pedroso de Lima, “MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma”, Journal of Controlled  Release, 2015, 207, 31-39 (Impact factor 7.26)

P.M. Costa, A.L. Cardoso, L.S. Mendonça, A. Serani, C. Custódia, M. Conceição, S. Simões, J.N. Moreira, L. Pereira de Almeida, M.C. Pedroso de Lima, “Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment”, Molecular Therapy – Nucleic Acids, 2013, 2:e100.  (Impact factor – 6.4)

A.L.C. Cardoso, P. Costa, S. Simões, L.P. de Almeida, N. Plesnila, C. Culmsee, E. Wagner, M.C. Pedroso de Lima; “Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage”, Journal of Controlled Release, 2010, 142, 392-403. (Impact factor – 7.1)

 
   
© 2017 CNC - Center for Neuroscience and Cell Biology powered by ponto.C