Ana Ledo
230 820 190
Post-doctoral researcher and Manager, BrainSense, lda.
Group at CNC

Personal Info.:
Name: Ana Ledo
Birthdate: 31/03/1077
Nationality: Portugues and Canadian

2007 – PhD in Biochemistry, University of Coimbra, Portugal
2001 – Biochemistry, University of Coimbra, Portugal

2007-2008 – Postdoctoral fellow, Center for Biomedical Research, University of Algarve.
2008-2009 – Post-doctoral fellow at Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2009-2014 – Auxiliary researcher, Center for Neurosience and Cell Biology, University of Coimbra, Portugal
2014-Present day: General manager at BrainSense, Lda.




Area of Research: 

1 – Neurometabolic and neurovascular coupling in Epilepsy;

2 – Development of electrochemical sensors and biosensors for recording of neurtransmitters (glutamate, dopamine, nitric oxide) and metabolites (oxygen, glucose and lactate) in the central nervous system.

3 – Chronical recordong of oxygen and glutamate in the central nervous system. Electrochemical methodologies associated with ultra-microelectrodes;


Research Summary:
Selected Publications: 

Lourenço, et al. “Neurovascular and neurometabolic derailment in aging and alzheimer's disease.”  Frontiers in Aging Neuroscience, 2015 7(103). IF: 4.725

Ledo et al. “Dynamic and interacting profiles of NO and O2 in rat hippocampal slices.” Free Rad Biol Med, 2010, 48(8):1044-1050. IF. 5.855

Ledo, A. et al. “Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria.”  Frontiers in Bioscience, 2007, 12(3): 1094-1106.

Ledo et al. “Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor.” Proc. Natl Acad Sci, 2005, 102(48):17483–17488. IF: 10.563


Other information: 
Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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