Paula Agostinho
239 820190
Res. Associate FMUC & Core CV Neuromoduation group at CNC.IBILI
Group at CNC

PhD in Biology by University of Coimbra- 1998. Co-author of 63 publications in refereed journals (over 1500 citations, h-index-27). Investigator Responsible of research projects (FCT, GAI, Janssen-Cilag). Supervisor of PhD thesis (3 completed) and Master´s. students. Teacher in pre-graduate and graduate courses.



Area of Research: 

Neuroscience. Cellular and molecular mechanisms underlying the pathogenesis of Alzheimer's and prion diseases. The role of astrocytes in synaptic function and cognitive processes in physiological and pathological conditions. Neuroprotection afforded by manipulation of adenosine receptors.)

Research Summary:
Selected Publications: 

- Pliássova A, Lopes JP, Lemos C, Oliveira CR, Cunha RA, Agostinho P. (2015) The association of amyloid-β protein precursor with α- and β-secretases in mouse cerebral cortex synapses is altered in early Alzheimer's disease. Mol Neurobiol. 2015 (em impressão). (Impact factor- 5.137, Quartil 1).

- Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF. (2015) Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to Schizophrenia. Biol Psychiatry. 78:763-74. doi: 10.1016/j.biopsych.2015.02.026. (Impact factor- 10.255, Quartil 1).

- Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, Agostinho P. (2012) Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia. 60(5):702-16  doi: 10.1002/glia.22290. (Impact factor- 5.47; Quartil 1, citações Web of Science: 33).

- Lopes JP, Oliveira CR, Agostinho P. (2010) Neurodegeneration in an A beta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell. 9: 64-77. doi:10.1111/j.1474-9726.2009.00536.x (Impact factor- 7.15, Quartil 1, citações Web of Science: 39)

- Agostinho P, Duarte CB, Oliveira CR (1997) Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: Effect of antioxidants. FASEB J. 11(2): 154-163. (Impact factor- 14.65, Quartil 1, citações Web of Science: 50).

Financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade – COMPETE 2020 e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projecto Estratégico com referência atribuida pelo COMPETE: POCI-01-0145-FEDER-007440

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