Joana M Marques
239 820 190
joana.marques@cnc.uc.pt
Post-Doc
Group at CNC
Education: 

2015/present - Ph.D. investigator (grantee at Fundação para a Ciência e a Tecnologia, Portugal) at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

2014/2015 - Ph.D. investigator (grantee at Universidade de Coimbra, Coimbra, Portugal) at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

2007/2013 - Ph.D student (grantee at Fundação para a Ciência e a Tecnologia, Portugal) at the Instituto de Neurociencias de Alicante, Spain, under supervision of Prof. Juan Lerma (CSIC).

2006/2007 - Project investigator (grantee at CSIC- Consejo Superior de Investigaciones Cientificas, Spain) at Prof. Juan Lerma’s laboratory, at the Instituto de Neurociencias de Alicante, Spain.

2003/2006 - Project investigator (grantee at Agência de Inovação, Fundação para a Ciência e a Tecnologia, Portugal) at the Institute of Microbiology of the Faculty of Medicine, University of Coimbra, Portugal.

2003/2005 - Master student at the Centre for Neurosciences and Cell Biology of the University of Coimbra, Portugal.

2002 - Undergraduate student at the Institute of Microbiology of the Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Afiliation: 

CNC

Area of Research: 

During my PhD I could provide the first link between activity and neurocytoskeleton dynamics during neuronal development, raising KAR as the key tether linking synaptic contact formation and neuronal maturation, which represented a conceptual breakthrough in brain development. We also found that this mechanism is reactivated during epileptogenesis that may be responsible for the aberrant axonal sprouting thought to underlie recurrent spontaneous seizures, the hallmark of Epilepsy (unpublished). This prompted me to explore brain diseases from the perspective of brain development, under the rationale of the existence of an aberrant re-wiring of brain circuits that contributes to the evolution of neurodegenerative disorders.

Research Summary: 
http://orcid.org/0000-0002-7234-9477
Selected Publications: 

1.    Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F and Cunha RA (2016) “Presynaptic P2X1-3 and α3-containing nicotinic receptors assembler into functionally interacting ion channels in the rat hippocampus” Neuropharmacology [DOI: 10.1016/j.neuropharm.2016.01.022] IF: 5.106.

2.    Joana M Marques, Ricardo J Rodrigues, Sergio Valbuena, Jose L Rozas, Sanja Selak, Philippe Marin, Maria I Aller and Juan Lerma (2013) “CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation” Journal of Neuroscience 33(46):18298-18310. [DOI: 10.1523/JNEUROSCI.3136-13.2013] IF: 6.343

3.    Juan Lerma & Joana M Marques (2013) “Kainate receptors in health and disease” Neuron 80(2):292-311. Featured Article. [DOI: 10.1016/j.neuron.2013.09.045] IF: 15.982.

Other information: 
 
   
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