Aquaporins in membranes: novel targets for drug discovery
Graça Soveral Research Institute for Medicine, iMed. Ulisboa

CNC Auditorium (2nd floor)
University of Coimbra, POLO I

Aquaporins in membranes: novel targets for drug discovery
Graça Soveral

Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.

Water is the major component of cells and tissues throughout all forms of life. Fluxes of water and solutes through cell membranes and epithelia are essential for osmoregulation and energy homeostasis.
Aquaporins (AQPs) are membrane channels expressed in almost every organism and involved in the bidirectional transfer of water and small solutes across cell membranes. AQPs have important biological roles and have been implicated in several pathophysiological conditions. In the last decade, the aquaporin field became a very hot area of research with increasing physiological and medical implications. Detecting aquaporin expression and function in cells and tissues is critical for assessing regulation and screening for new activity modulators that can prompt the development of efficient medicines.
This seminar will cover different approaches to investigate AQPs as potential drug targets opening new perspectives to untangle mechanisms of disease and aquaporin-based diagnostics and therapeutics.

Funded by ERDF - European Regional Development Fund through COMPETE 2020 and National Funds via FCT - Fundação para a Ciência e Tecnologia, under projects POCI-01-0145-FEDER-007440 e UIDB/04539/2020.

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