Developmental programming of offspring obesity
2012.9.4
Michael G. Ross Geffen School of Medicine, UCLA UCLA School of Public Health USA
September 04th 2012, 12h00, CNC Auditorium (2nd floor, old FMUC building, Pólo I)

Host: Cláudia Cavadas


Summary:
"A newly recognized, primary cause of the obesity epidemic is the developmental programming effects of the in utero environment, par<cularly exposure to the increasingly common condi<ons of maternal obesity and a Western, high fat diet. Rodent models replicate human evidence, as offspring from obese, high fat (HF) fed dams are hyperphagic and develop adult obesity. We have demonstrated that both programmed hyperphagia and adipogenesis result in a predisposi<on to adult obesity, following either perinatal under--‐ or over--‐nutri<on. We will review the epidemiologic data and the likely cellular/molecular mechanisms of programmed hyperphagia/adiposity which contribute to offspring obesity."
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