CNC Internal Newsletter
Issue 2 | August 2017
Publications July | August

Performance of HADDOCK and a simple contact-based protein-ligand binding affinity predictor in the D3R Grand Challenge 2.
Kurkcuoglu Z, et al. J Comput Aided Mol Des. 2017 Aug 22

Therapeutic strategies targeting oxidative stress to improve dyslipidemia and left ventricular hypertrophy.
Reis F. Rev Port Cardiol. 2017 Aug 18

SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots.
Moreira IS, et al. Sci Rep. 2017 Aug 14

Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis.
Costa BP, et al. J Surg Res. 2017 Aug

Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles.
Miranda A, et al. Int J Pharm. 2017 Aug 8

Id genes are essential for early heart formation.
Cunningham TJ, et al. Genes Dev. 2017 Aug 9

Alzheimer's disease-related amyloid-β1-42 peptide induces the loss of human sperm function.
Tavares RS, et al. Cell Tissue Res. 2017 Aug 3

Functional and structural characterization of synthetic cardosin B-derived rennet.
Almeida CM, et al. Appl Microbiol Biotechnol. 2017 Aug 2


Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts.
Coelho AR, et al. Biochim Biophys Acta. 2017 Jul 28

Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches.
Miranda A, et al. Int J Pharm. 2017 Jul 27

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria.
Teixeira J, et al. Sci Rep. 2017 Jul 28

Photocatalytic ozonation using doped TiO2 catalysts for the removal of parabens in water.
Gomes JF, et al.Sci Total Environ. 2017 Jul 25

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.
Sousa J, et al. Res. 2017 Jul 26

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models.
Teixeira J, et al. J Med Chem. 2017 Aug 24

Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway.
Wojtala A, et al. Mitochondrion. 2017 Jul 21

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Gonçalves D, et al. Neuropharmacology. 2017 Jul 19



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Awards / Honors

Certificate “Boas Práticas de Laboratório” (BPL) (in accordance with Directiva 2004/9/CE)

Laboratório de Reprodução Humana
Field of work: Toxicological Experiments (in vitro Assays)
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Public Engagement in Science

We’re getting social.

We are now on LinkedIn, Instagram, Twitter and Google+. Follow us and share our posts.

Find us also on Facebook and YouTube.

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Research Grants:

BEB PhD Programme Fellowships:

Four founded scholarships available
Applications: until 6 October

Research Positions:

• Pos-Doctoral Research Position – Scientific Area: “Neuroscience and Brain diseases – Neuronal circuits and behavior” - D.L. 57/2016; D.L. 57/2017
Applications: until 3 October

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New faces | New roles

Tatiana Catarino

MICC-CNC staff member
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Get Involved
CNC Seminars

@CNC, Pólo I, Coimbra

“Aquaporin channels in obesity and cancer: discovery of new pharmacological blockers”
Graça Soveral - Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon
Host: João Laranjinha
8 September

“Mitochondrial movement in Alzheimer's disease: don't stop me now!”
Sónia Correia - Cell Metabolism and Quality Control Group, CNC
Host: Paula Moreira
15 September

• (To be confirmed)
22 September

“Targeting the hypothalamus to mitigate obesity”
Sara Carmo-Silva - Group of Neuroendocrinology and Aging, CNC
Host: Cláudia Cavadas
29 September

@ CNC, UC-Biotech, Cantanhede

“Plant biofactories for the production of recombinant proteins”
Rita Abranches - ITQB, Universidade Nova de Lisboa
Host: Isaura Simões
6 September

“Development of efective antidotes for Amanita phalloides”
Félix Carvalho - Faculdade de Farmácia da Universidade do Porto
Host: Ana Teresa Carvalho
20 September



11 September | 14:30h @CNC Auditorium
Join Us! All CNC members are invited
Registration here

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Lia Lopes and Ana Sofia Mergulhão