CNC Internal Newsletter
Issue 4 | October 2017
Publications September | October

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease.
Sjögren M, et al. Sci Rep. 2017 Oct 24

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
Spadari RC, et al. Cell Mol Neurobiol. 2017 Oct 24

Impact of developmental exposure to methylphenidate on rat brain's immune privilege and behavior: control versus ADHD model.
Coelho-Santos V, et al. Brain Behav Immun. 2017 Oct 20

Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function.
Craveiro M, et al. Sci Signal. 2017 Oct 17

Adiponectin and sporadic Alzheimer's disease: Clinical and molecular links.
Letra L, et al. Front Neuroendocrinol. 2017 Oct 13

A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial oxidative phosphorylation genes in gilthead sea bream (Sparus aurata).
Silva-Marrero JI, et al. BMC Genomics. 2017 Oct 11

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.
do Amaral RJFC, et al. Stem Cells Int. 2017

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Boia R, et al. Cell Death Dis. 2017 Oct 5

Steroidal oximes: useful compounds with antitumor activities.
Canário C, et al. Curr Med Chem. 2017 Oct 3



The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression.
Vecchione G, et al. Front Nutr. 2017 Sep 19

Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells.
Oliveira AI, et al. Cell Commun Signal. 2017 Oct 2

Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology.
Vieira de Castro J, et al. J Transl Med. 2017 Oct 2

Computational studies of G protein-coupled receptor complexes: Structure and dynamics.
Sensoy O, et al. Methods Cell Biol. 2017

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.
Aday S, et al. Nat Commun. 2017 Sep 29

A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid's proteome.
Trindade F, et al. Arch Biochem Biophys. 2017 Sep 23

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease.
Silva AC, et al. Biochim Biophys Acta. 2017 Sep 20

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors.
Cunha PP, et al. Hum Mol Genet. 2017 Aug 16

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Lemos V, et al. Hum Mol Genet. 2017 Jul 26

Let us know if you have more information to add to this section.
Awards / Honors
2nd Prize on “Hack4 Aging Well – Hackathon” [see here]
Team: André Carvalho, João Cardoso, Helena Leal, Marisa Ferreira-Marques e Patrick Silva

Scientific Outreach Grant from the Biochemical Society
Project: “Brain Buskers”. P.I.: Sara Varela Amaral

This project starting in January 2018 aims to explore biochemical phenomena using scientific expertise of CNC researchers, spreading scientific messages through the city at public spaces – pubs, buses, parks, street, beach, shopping’s, etc. If you would like to participate in this initiative, please contact the Science Communication Office:

Best Scientific Poster from the Innovative Competition (AstraZeneca Foundation), iMed 9.0 Conference, Lisbon (Portugal)
“Sirtuin 2 as a new player and putative target to treat non-alcoholic fatty liver disease (NAFLD)” – João Cardoso
2nd Prize on “Hack4 Aging Well – Hackathon
Best Scientific Poster from the Innovative Competition
(João Cardoso)
Let us know if you have more information to add to this section.
Scientific Meetings and Events

“Hack4 Aging Well – Hackathon” | 30 September – 1 October 2017, Coimbra (Portugal) [see here]
Participation of André Carvalho, João Cardoso, Helena Leal, Marisa Ferreira-Marques e Patrick Silva

SciComPt 2017 (5th National Congress of Science Communication) | 12 – 13 October, Coimbra (Portugal) [see here]

CNC members participation:
Sara Varela Amaral, Cláudia Cavadas- “Qual o papel dos Gabinetes de Comunicação das instituições científicas: dos media ao outreach, dos cientistas à sociedade”.
Ana Teresa Viegas - “A Ciência na Internet: o papel das Redes Sociais.”
Ricardo Pires - “Quem tem medo dos jornalistas?”
Sara Varela Amaral - “A ciência como objecto do teatro - modos de interacção.”
João Ramalho-Santos - “Comunicar ciência aos quadradinhos: oportunidades, riscos e desafios.”
Paulo Oliveira - “Da Célula à Escola.”

iMed 9.0 Conference | 25 29 October 2017, Lisbon (Portugal) [see here]
João Cardoso – Poster presentation
SciComPt 2017
Let us know if you have more information to add to this section.
Public Engagement in Science

Noite Europeia dos Investigadores | 29 September, at Museu da Ciência da Universidade de Coimbra, Coimbra (Portugal) [see here]

o More than 70 CNC researchers participated at this event.

o 8 hands-on activities with public, speed datings and art & science workshop

o Impact evaluation of hands-on activities:

Noite Europeia dos Investigadores

The Science Communication Office would like to thank everyone who participated at this event.

Culturgest – Ciclo de Conferências “Discursos do Cérebro” | September – October 2017, Lisboa (Portugal) [see here]

Participation of Cláudia Cavadas – “À procura do elixir da juventude” [see the video here]

Festival de Ciência | 4 – 6 October, Oliveira do Bairro (Portugal) [see here]

o Hands-on activities with the public | 4 – 6 October

o Workshop “Dar Corpo ao Cérebro | 5 October
Ana Teresa Viegas and Ana Rita Álvaro

o Debate “Conversa Cons(ciência)” | 5 October
Sara Matias Silva

1st PubhD Coimbra | 12 October 2017, Aqui Base Tango, Coimbra (Portugal) [see here]
Participation of Ana Teresa Viegas “Envelhecimento e Neurociências”

We’re getting social.

We are now on LinkedIn (@CNC UC), Instagram (@cnc.uc), Twitter (@cnc uc) and Google+ (CNC UC) accounts. Find us also on Facebook (@CNC UC) and YouTube (@CNCmediachannel

Festival de Ciência
1st PubhD Coimbra
Let us know if you have more information to add to this section.
CNC on the News

• Interview with Cláudia Cavadas in Diário de Notícias on the Noble Prize in Medicine. [see here]

• Interview with Cláudia Cavadas in Máxima on her talk at CulturGest. [see here]

• Interview with Cláudia Cavadas in Saúde Online on CNC research work on sleep apnea diagnosis. [see here]

Let us know if you have more information to add to this section.


New faces | New roles

Raphael Santamaria
Treatment Project Fellow
PhD candidate
Giada Di Nunzio
Treatment Project Fellow
PhD candidate
Let us know if you have more information to add to this section.
Don’t miss out

The European Project Rise (Research and Innovation Staff Exchange Project) “mtFOIE GRAS” was launched on July 2017. [see here]
o The project is funded by Horizon 2020 Marie Sk?odowska-Curie Actions and aimed at promoting the mobility of scientists and technicians between academia, companies and patient associations.

CNC / ISCAC 2017 Courses
o Gestão de Riscos – 14h – 2 days
o Marketing Digital – 18h – 3 days
o Liderar e Gerir equipas de Projetos – 18h – 3 days
o Finanças para não financeiros – 21h – 3 days
o Como elaborar um plano de negócios – 14h – 2 days
o Contratação Pública - 14h -2 days
o Inteligência Emocional e gestão conflitos – 18h – 3 days
o Regulamento Geral sobre a Proteção de Dados – 7h – 1 days

Interested parties are requested to send an email to until 15th November indicating which courses would be useful.

On November 2nd, microbiological tests will be conducted in the cell culture rooms of Polo I. For this reason, during the periods of time that the flow chambers are booked in the name of Isabel Nunes, it will not be possible to enter in the cell culture rooms.

We invite you to fill out the Google Form to allow for the gathering of information regarding the CNC’s community. Please click here.

Let us know if you have more information to add to this section.
Get Involved
CNC Seminars
Fall Series - Next talks

@CNC / UC-Biotech, Cantanhede

“Synaptic dysfunction in neuropsychiatric disorders”
Ana Luísa Carvalho (CNC, Coimbra)
Host: Paulo Oliveira
November 2

“Biolmage analysis – how an image is worth a thousand datapoints”
Paulo Aguiar (I3S/INEB, University of Porto)
Host: Hugo Fernandes
November 15

“The transgenic chicken bioreactor”
Lissa Herron (SER/BBSRC Enterprise Fellow, The Roslin Institute, University of Edingurgh, Scotland)
Host: Ricardo Pires
November 22

“Coordinating global endotelial collective cell polarity in angiogenesis”
Cláudio Areias Franco (IMM, University of Lisbon)
Host: Lino Ferreira
November 29

@CNC, Pólo I, Coimbra

“Inflammation-driven disruption of iron homeostasis in Parkinson’s disease”
Raffaella Gozzelino (NOVA Medical School, CEDOC, Lisbon)
Host: Paulo Oliveira
November 3

“LncRNAs in stemness and cancer”
Bruno Jesus (IMM, University of Lisbon)
Host: Carlos Duarte
November 10

“The Good, the Bad and the Ugly: food bacteria, from the gut to the brain”
John D. Marugg (CNC, Coimbra)
Host: Henrique Girão
November 30


Join us today @CNC Library, 1st floor (Polo I) | 18h30
Just bring a mug and some food for a light supper
Let us know if you have more informations or any suggestions, to improve "Synergies"


Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Claudia Cavadas (Coordinator)
Design and Layout:

Lia Lopes and Ana Sofia Mergulhão