CNC Internal Newsletter
Issue 3 | September 2017
Please click here to see this properly.
Publications August | September

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.
Pereira SG, et al. Front. Microbiol. 2017 Sep 21

Multiple Sclerosis: Implications of Obesity in Neuroinflammation.
Novo AM, Batista S. Adv Neurobiol. 2017 Sep 21

The Influence of Adipose Tissue on Brain Development, Cognition, and Risk of Neurodegenerative Disorders.
Letra L, Santana I. Adv Neurobiol. 2017 Sep 21

Diabesity and Brain Energy Metabolism: The Case of Alzheimer's Disease.
Cardoso S, et al. Adv Neurobiol. 2017 Sep 21

Hypothalamic Dysfunction in Obesity and Metabolic Disorders.
Carmo-Silva S, Cavadas C. Adv Neurobiol. 2017 Sep 21

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease.
Silva AC, et al. Biochim Biophys Acta. 2017 Sep 19

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes.
Gonçalves J, et al. Mol Autism. 2017 Sep 19

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.
Gregório AC, et al. Pathol Oncol Res. 2017 Sep 14

Matrisome Profiling During Intervertebral Disc Development And Ageing.
Caldeira J, et al. Sci Rep. 2017 Sep 14

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats.
Costa BPD, et al. Acta Cir Bras. 2017 Aug

Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study.
Rita Machado A, et al. Sci Rep. 2017 Sep 12


Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death.
Pereira LC, et al. J Toxicol Environ Health A. 2017 Sep 7

Distinct sensitivity to caffeine-induced insomnia related to age.
Frozi J, et al. J Psychopharmacol. 2017 Aug 1

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase.
Cereija TB, et al. Acta Crystallogr F Struct Biol Commun. 2017 Sep 1

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects.
Cardoso S, et al. Neurotox Res. 2017 Sep 5

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography.
Magalhães P, et al. J Anal Toxicol. 2017 Sep 1

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.
Amorim JA, et al. J Alzheimers Dis. 2017 Sep 1

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity.
• Ferreira A, et al. Toxicology. 2017 Sep 1

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.
Ribeiro-Rodrigues TM, et al. Cardiovasc Res. 2017 Sep 1

Oral vaccination through Peyer's Patches: update on particle uptake.
Soares E, Borges O. Curr Drug Deliv. 2017 Aug 25

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.
Morató X, et al. Sci Rep. 2017 Aug 25

Screening of pharmacokinetic properties of fifty dihydropyrimidin- (thi)one derivatives using a combo of in vitro and in silico assays.
Matias M, et al. Eur J Pharm Sci. 2017 Aug 2

Let us know if you have more information to add to this section.
Events at CNC
Welcome Day and 7th Beer for Thought at Pólo I
11 September [see here]
III Quantitative Fluorescence Microscopy Course at Pólo I
18 – 22 September [see here

FOIE GRAS ESRs Kick-off meeting and First Summer School “Tools and rationale for measuring mitochondrial function in intact cells and isolated mitochondria” at UC-Biotech
18 – 22 September [see here

Let us know if you have more information to add to this section.
Scientific Meetings and Events

30th ECNP Congress | 2 – 5 September, Paris (France) [see here]
Participation of Cláudia Cavadas – “Neuropeptide Y stimulates autophagy in hypothalamic neurons”
Let us know if you have more information to add to this section.
Public Engagement in Science

Conference “Discursos do Cérebro” | 11 September, Culturgest – Fundação CGD, Lisbon (Portugal)
Participation of Sandra Morais Cardoso – “Mitocôndria, no caminho das doenças neurodegenerativas.” Click here to watch the video.

Ciência Viva no Verão em Rede | 1 – 12 September, at Café Santa Cruz, collaboration with Rómulo – Centro de Ciência Viva: 
• “Ciência na Rua” – hands-on activities with the public | 1 – 12 September [see here]
• “Ciência ao Luar” – scientific café | 5 September
“Alimentação para a saúde” – Sara Matias Silva e Ana Ramalhas [see here]

We’re getting social.

We are now on LinkedIn (@CNC UC), Instagram (@cnc.uc), Twitter (@cnc uc) and Google+ (CNC UC) accounts. Find us also on Facebook (@CNC UC) and YouTube (@CNCmediachannel)

Let us know if you have more information to add to this section.
CNC on the News

News about the project “New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors”, winner of Bolsa Edgar Cruz e Silva. Read here.

News about the CNC research work on transport and photoactivation of chemotherapy. Read here.

Let us know if you have more information to add to this section.
Research Grants:

BEB PhD Programme Fellowships [see here]:

Four founded scholarships available
Applications: until 6 October

• One Master position – Project: “ARCADELIKE - Development of a physiological collagen architecture in engineered tissue cartilage through a combined approach of mechanical stimulus with anisotropic fibrous scaffolds on a bioreactor environment” [see here]:
Applications: until 6 October

• Two Master positions – Project: “Matafluidics – Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics”
Microbiology field [see here]
Bioinformatics field [see here]
Applications: until 6 October

• One Master position – Project: “MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria” [see here]:
Applications: until 26 October

• One Master position – Project: “EXERCISING THE FUTURE: Voluntary Exercise During Gestational Diabetes as a Means to Improve Mitochondrial Function in the Offspring” [see here]:
Applications: until 26 October

Research Positions:

• Pos-Doctoral Research Position – Scientific Area: “Neuroscience and Brain diseases – Neuronal circuits and behavior”[see here]
Applications: until 3 October

Let us know if you have more information to add to this section.

New faces | New roles

Mireia Alemany Pàges
FOIE GRAS Early Stage Fellow
(PhD Candidate)
Getachew Debas
FOIE GRAS Early Stage Fellow
(PhD Candidate)
Let us know if you have more information to add to this section.
Don’t miss out

• CNC technicians have new and official lab coats.

• We invite you to fill out the Google Form to allow for the gathering of information regarding the CNC’s community. Please click here.

• The MICC team office moved to the 2nd floor, at CNC-Polo I.
The office is now located in front of the MICC-room I, after the Neuro-Proteomics Lab (room 201A).
Phone extension: 143.

• Launch of the “Neurociências” book [see here]
Coordination: Ana Cristina Rego, Carlos B. Duarte e Catarina R. Oliveira
Authors: several CNC members
Edition: Lidel, 2017
To purchase, click here.

Let us know if you have more information to add to this section.
Get Involved
CNC Seminars
Fall Series

@CNC, Pólo I, Coimbra

“Targeting the hypothalamus to mitigate obesity”
Sara Carmo-Silva – CNC, Coimbra
Host: Cláudia Cavadas
29 September

“From Goethe to modern days: Bryophyllum pinnatum in obstetrics”
Ana Paula Simões-Wüst – University Hospital Zurich, Switzerland
Host: Teresa Gonçalves
3 October

“Metabolic studies in different organisms using deuterated water”
John Jones – CNC/UC-Biotech
Host: Ermelindo Leal
6 October


“Inhibition of mitral cells determines odour discrimination time in mice”
Daniel Nunes – Champalimaud Foundation, Lisbon
Host: Carlos Duarte
13 October

“Metabolic adaptations in cancer and ageing”
Sandrina Nóbrega Pereira – IMM, University of Lisbon
Host: Emília Duarte
20 October

“An evolutionary perspective on the (epi)genetic regulation of gamete function”
Paulo Navarro-Costa – Instituto Gulbenkian de Ciência, Oeiras
Host: João Ramalho-Santos
27 October


Join us today @ Museu da Ciência da UC 21h - 00h
Let us know if you have more informations or any suggestions, to improve "Synergies"


Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Claudia Cavadas (Coordinator)
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Lia Lopes and Ana Sofia Mergulhão