CNC Internal Newsletter
Issue 8 | February 2018
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  Publications January | February

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma.
Mendes M, et al. Eur J Pharm Sci. 2018 Feb 24

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease.
Duarte AI, et al. Neuropharmacology. 2018 Feb 19

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.
Hiremathad A, et al. Eur J Med Chem. 2018

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP, et al. Cell Death Dis. 2018 Feb 20

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants.
Teixeira J, et al. Int J Biochem Cell Biol. 2018 Feb 14

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
Bicker J, et al. Eur J Pharm Sci. 2018 Feb 8

Stem Cell-Based Therapies for Polyglutamine Diseases.
Mendonça LS, et al. Adv Exp Med Biol. 2018

Gene Therapies for Polyglutamine Diseases.
Matos CA, et al. Adv Exp Med Biol. 2018

Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.
Nóbrega C, et al. Adv Exp Med Biol. 2018

Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease.
Carvalho AL, et al. Adv Exp Med Biol. 2018

Clinical Features of Machado-Joseph Disease.
Mendonça N, et al. Adv Exp Med Biol. 2018

 

Mitochondrial Dysfunction in Huntington's Disease.
Carmo C, et al. Adv Exp Med Biol. 2018

An easy-to-use liquid chromatography method with fluorescence detection for the simultaneous determination of five neuroactive amino acids in different regions of rat brain.
Fonseca BM, et al. J Pharmacol Toxicol Methods. 2018 Feb 6

Elevated Pressure Changes the Purinergic System of Microglial Cells.
Rodrigues-Neves AC, et al. Front Pharmacol. 2018 Jan 24

Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?
Silva AF, et al. PLoS One. 2018 Feb 7

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.
Marques-Aleixo I, et al. Biochim Biophys Acta. 2018 Feb 12

Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant.
Bacalhau M, et al. Neuromuscul Disord. 2017 Nov 23.

Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases.
Zerr I, et al. Alzheimers Dement. 2018 Feb 3

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Ferreira A, et al. Food Res Int. 2018 Jan

TRAP1 regulates autophagy in lung cancer cells.
Barbosa IA, et al. Eur J Clin Invest. 2018 Jan 31

Raineya orbicola gen. nov., sp. nov. a slightly thermophilic bacterium of the phylum Bacteroidetes and the description of Raineyaceae fam. nov.
Albuquerque A. et al. IJSEM. Epub 2018 Jan 10

 

 

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Awards / Honors

Marie Sktodowska-Curie Individual Fellowship | February, 2018
Catarina Seabra – Neuronal Circuits and Behavior Group (P.I.: João Peça)

Project: “ProTeAN” – Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders”.



FLAD Healthcare 2020 | February, 2018
Mitochondrial Toxicology and Experimental Therapeutics Group (P.I.: Paulo Oliveira)

Project: "MOTS-c Peptide as a Mediator of Positive Metabolic Effects of Physical Activity"

Marie Sktodowska-Curie Individual Fellowship
FLAD Healthcare 2020
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Events @ CNC
Protocol signature with the European Universities Games (EUG Coimbra 2018) | 9 February 2018, CNC, Coimbra 2018

Science communication activities within the scope of Foie Gras project.



WildCard Session | 9 February 2018, CNC Auditorium, Coimbra



Health Research Call from LaCaixa Foundation | 9 February 2018, CNC Auditorium, Coimbra
Protocol signature with the European Universities Games (EUG Coimbra 2018)
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Scientific Meetings and Events


SPF Meeting 2018 | 5 – 7 February, 2018, Faculty of Medicine of University of Lisboa, Lisboa, Portugal
Presence of several CNC members.

Lecture by Cláudia Cavadas: Neuropeptide Y regulates Autophagy: a relevant mechanism in aging?” | 9 February, 2018, University of Catania, Italy



 
 
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Public Engagement in Science

• International Rare Diseases Day | 28 February, 2018
- Event “Doença de Machado-Joseph: do Laboratório para a Sociedade” | CNC Auditorium, Coimbra, Portugal
- Event “Avarias na Fábrica de Energia e outras Raridades” | Rómulo CCV, Coimbra, Portugal

• 6th PubhD Coimbra | 22 February, Aqui Base Tango, Coimbra, Portugal
- Participation of Marcos Gomes

• Talk of Manuela Grazina about biochemistry in the human body | 12 February, Biblioteca Municipal de Penamacor, Castelo Branco

• CNC participation in the International Day of Women and Girls in Science (United Nations initiative) | 11 February

- Ana Teresa Viegas, Mariana Laranjo, Marta Pereira e Sara Amaral [see here]
- Catarina Miranda [see here]
- Catarina Seabra [see here]
- Mireia Alemany [see here]

• Do you already know that we are on social media?
You can find us on Facebook (@CNC UC), LinkedIn (@CNC UC), Instagram (@cnc.uc), Twitter (@cnc uc), Google+ (CNC UC) and YouTube (@CNCmediachannel). Please follow us so you can be always updated!



6th PubhD Coimbra
 
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CNC on the Media

• News about the events regarding the Science Communication events related to the International Rare Diseases Day

o Interview with Luís Pereira de Almeida in Antena 1 | 28 February
- You can listen to [here] (minute 7:19) and [here] (minute 11:57)

o Diário de Notícias – mention to Luís Pereira de Almeida (in press and online) [see here] | 28 February

o News Farma [see here] | 27 February

o Diário As Beiras (in press) | 27 February

o A Cabra [see here] | 27 February

o Saúde Online [see here] | 27 February

o Diário de Coimbra (in press) | 26 February

o Diário As Beiras (in press and online) [see here] | 26 February

o Beira News [see here] | 25 February

o Notícias de Coimbra [see here] | 24 February


• News about the recent unit Centro de Investigação em Biomedicina e Biotecnologia (CIBB) in Diário as Beiras (in press) | 27 February


• News about the SleepApneia ID Project in Diário As Beiras (in press) | 17 February


• News about FLAD Healthcare 2020 award winning by the Mitochondrial Toxicology and Experimental Therapeutics Group

o VerPortugal [see here] | 16 February

o Índice.eu [see here] | 15 February

o TV Europa [see here] | 15 February

o Infocul [see here] | 15 February

o Diário dos Açores (in press) | 15 February

o Diário de Leiria (in press) | 15 February

o Diário de Coimbra (in press) | 15 February

o Diário As Beiras (in press) | 15 February

o Campeão das Províncias (in press) | 15 February
-Column “Figuras da Semana” – Paulo Oliveira

o BeiraNews [see here] | 15 February

o TSF [see here] | 14 February

o Sapo Lifestyle [see here] | 14 February

o Rua Direita [see here] | 14 February

o Notícias de Coimbra [see here] | 14 February

o Notícias ao Minuto [see here] | 14 February

o Jornal É Notícia [see here] | 14 February

o Jornal de Notícias [see here] | 14 February

o O Jogo [see here] | 14 February

o iPress Jorunal [see here] | 14 February

o i9 Magazine [see here] | 14 February

o Green Savers [see here] | 14 February

o Diário de Notícias [see here] | 14 February

o Campeão das Províncias [see here] | 14 February

o Boas Notícias [see here] | 14 February


• News about Manuela Grazina talk in Biblioteca Municipal de Penamacor in Reconquista [see here] | 11 February


• News about the partnership and protocol signature with the European Universities Games (EUG Coimbra 2018)

o Diário de Coimbra (in press) | 12 February

o O Despertar (in press) | 9 February

o Campeão das Províncias [see here] | 9 February

o A Cabra [see here] | 9 February

o Diário de Coimbra (in press) | 7 February

o Notícias de Coimbra [see here] | 6 February

o Atletismo Magazine [see here] | 6 February

• Interview with Luís Pereira de Almeida and Cláudia Cavadas about Machado-Joseph disease in Antena 2 | 5 February


Let us know if you have more information to add to this section.
Opportunities
Research Grants at CNC:

One Post-Doctoral Fellowhsip:
Project: Identification and functional characterization of microRNAs controlling cardiac ischemia reperfusion injury [see here]
Application deadline: 6 March, 2018

• One Master’s Research Fellowship:
Project: CANCEL_STEM “Tackling cancer stem cells: a challenge and an opportunity to advance in anti-cancer therapy” [see here]
Application deadline: 9 March, 2018

• One Master’s Research Fellowship:
Project: ESMI “European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative”
Application deadline: 14 March, 2018 [see here]

• One Master’s Research Fellowship:
Project: ProSafe/0001/2016  “Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions” [see here]
Application deadline: 26 March, 2018






Other Oportunities:

• FCT Doctoral Research Fellowships – Open Call
o   Application deadline: 28 March [see here]

• INEO Start ‘18 – Open Call
10 April – 16 May | Weekly sessions (Tuesdays or Thursdays from 14h to 19h) [see here]


Let us know if you have more information to add to this section.
 

New faces | New roles
 

   
Marina Barbosa
Bacherlor’s Student
Foie Gras Group
   
Let us know if you have more information to add to this section.
Don’t miss out

• FameLab Portugal – International Science Communication Competition [see here]

Important dates:
1 – 2 March – Application Results
6 March (14:30) – Regional Final at Museu da Ciência, University of Coimbra

The Science Communication Office would like to thank the researchers who participated in this competition.


• CNC participation in a documentary about the University of Coimbra | 9 February 2018
Neuronal Circuits and Behavior Group


• GPS (Global Portuguese Scientists) – Online Network that connects Portuguese researchers around the world [see here]

The Science Communication Office would like to encourage the researchers to join this online scientific network.



 

FameLab Portugal
 
 
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PhD Defenses
   
Sofia Romano | 20 February, 2018
Thesis: "Novel Anti-Nucleolin Antibodies for Targeted Cancer Therapy”
Supervisors: João Nuno Moreira and João Gonçalves (Faculdade de Farmácia, Universidade de Lisboa)
 
 
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Get Involved
 
CNC Seminars
Winter Series - Next talks

@CNC / UC-Biotech, Cantanhede – 11h30

• “Use of the cytoskeleton to control Shigella Infection”
Serge Mostowy (Imperial College London, UK)
Host: Ana Eulálio
March 7

• “Mood disorders: controversies on nosologic and nosographic aspects”
Carlos Saraiva (Faculty of Medicine, University of Coimbra)
Host: Paulo Oliveira
March 15

• “Environmental microbiology: from basic ecology to biotechnology”
Newton Gomes (CESAM and University of Aveiro)
Host: Conceição Egas
March 21

@CNC, UC - Pólo I, Coimbra – 14h

• “AGEing in obesity and type 2 diabetes: glycotoxins and imaging biomarkers in metabolic disorders”
Paulo Matafome (ESTeSC and IBILI, University of Coimbra)
Host: Ermelindo Leal
March 2

• “Enteropathogens shape microbiota biofilms: New insights into the causes of post-infectious inflammation”
Andre Buret (Department of Biological Sciences, University of Calgary, Canada)
Host: Gabriela Silva
March 5

• “A dormant blood microbiome, host iron dysregulation and LPS-induced coagulopathies underpin a large range of chronic, inflammatory diseases: a systems biology approach”
Douglas B. Kell (Manchester Institute of Biotechnology, The University of Manchester, UK)
Host: Nuno Empadinhas
March 9

• To be announced
Host: Cláudia Cavadas
March 16

• “Prevention of the dysregulation of BDNF signaling as a possible therapeutic strategy for Alzheimer’s Disease”
Maria José Diógenes (IMM, Faculty of Medicine, University of Lisbon)
Host: Ana Cristina Rego
March 23

• “From womb to tom: how developmental programming interacts with aging”
Peter W. Nathanielsz (Texas Biomedical Research Institute and Southwest National Primate Research Center, University of Wyoming, San Antonio, USA)
Host: Paulo Oliveira
March 28


PDBEB Advanced Courses 2017/2018 [see here]


Fighting infection
February 5 - 9, 2018

Aging: from cellular processes to the organism
March 5 - 9, 2018


Cardiovascular Sciences (Optional, FMUC)
March 12 - 16, 2018

Metabolism and Disease
March 26 - 30, 2018

Synapses, Neuronal Circuits and Behavior - Supported by FENS/IBRO-PERC
April 9 - 20, 2018
FENS and IBRO-PERC provides 4 stipends of 750 EUR for master and/or PhD students interested in attending this course.

Neurodegenerative disorders
April 23 - 27, 2018

Advanced Therapies
May 7 - 11, 2018

Drug Development
May 21 - June 1, 2018


International Brain Awareness Week (12 - 18 March)

We cellebrate this initiative during the whole month of March (1 - 30 March)
The Science Communication Office would like to invite you to join us in our activities.

If you would like to participate, please contact us: scicomm@cnc.uc.pt
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Let us know if you have more informations or any suggestions, to improve "Synergies"
Credits

Contents:

Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Claudia Cavadas (Coordinator)
Design and Layout:

Lia Lopes and Ana Sofia Mergulhão