CNC Internal Newsletter
Issue 7 | January 2018
 
  Publications December | January

IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft.
Martins-Neves SR et al. Cancer Lett. 2018 Feb 1

Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats.
Cardoso-Cruz H et al. Eur J Pain. 2018 Jan 26

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study.
Ribeiro M, Castelhano J et al. J Magn Reson Imaging. 2018 Jan 26

Carbon-1 versus Carbon-3 Linkage of d-Galactose to Porphyrins: Synthesis, Uptake, and Photodynamic Efficiency.
Pereira PMR et al. Bioconjug Chem. 2018 Jan 26

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK.
Panisello-Roselló A et al. Int J Mol Sci. 2018 Jan 24

Co-Transplantation of Adipose tissue-derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair.
Gomes ED et al. Stem Cells. 2018 Jan 20

Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion.
Martins RM et al. Int J Mol Sci. 2018 Jan 19

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.
Teixeira J et al. Toxicology. 2018 Jan 15

Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream.
Rito J et al. Sci Rep. 2018 Jan 11

Stem cells as vehicles and targets of nanoparticles.
Pinho S et al. Drug Discov Today. 2018 Jan 11

Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells.
Palomo-Guerrero M et al. Neuroscience. 2018 Jan 11

 

Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.
Sargento-Freitas J et al. Neurology. 2018 Jan 9

Light-triggerable formulations for the intracellular controlled release of biomolecules.
Lino MM and Ferreira L. Drug Discov Today. 2018 Jan 8

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex.
Kerkhofs A et al. Front Pharmacol. 2018 Jan 4

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer.
Zupan?i? E et al. Nanomedicine. 2018 Jan 3

The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review.
Dionísio A et al. J Stroke Cerebrovasc Dis. 2018 Jan

Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy.
Passadouro M and Faneca H. Methods Mol Biol. 2018

Anaesthesia in Dental Medicine with Local Infiltrative Anaesthetic Technique Versus Diploe Anaesthesia Delivery Systems: Efficacy and Behaviour, an Experimental Study.
Marques-Ferreira M et al. Acta Med Port. 2017 Dec 29

Paraben degradation using catalytic ozonation over volcanic rocks.
Gomes JF et al. Environ Sci Pollut Res Int. 2017 Dec 23

Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin - Thioredoxin system. 1. Understanding commonalities and differences among cell types.
Selvaggio G at el. Redox Biol. 2017 Dec 21

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.
Teixeira J et al. Redox Biol. 2017 Dec 30

First Molecular Characterization of Hypoderma actaeon in Cattle and Red Deer (Cervus elaphus) in Portugal.
Ahmed H et al. Korean J Parasitol. 2017 Dec

 

 

Let us know if you have more information to add to this section.
 
Events @ CNC
• Advanced Course “Connecting the Researchers with the Society” | 22 – 26 January, CNC, Coimbra, Portugal





• Workshop “Integrating Glial and Neuronal Function in Health and Disease“ | 25 January, CNC, Coimbra, Portugal




• BEB Day | 18 – 19 January, CNC, Coimbra, Portugal




• 10th Beer For Thought - Included in BEB Day Programme | 19 January, CNC, Coimbra, Portugal
Advanced Course “Connecting the Researchers with the Society”
Workshop “Integrating Glial and Neuronal Function in Health and Disease“
10th Beer for Thought
BEB Day
Let us know if you have more information to add to this section.
Scientific Meetings and Events


XII Spanish-Portuguese Conference on Controlled Drug Delivery | 14 – 16 January, Coimbra, Portugal
o Organized by João Nuno Moreira




XII Spanish-Portuguese Conference on Controlled Drug Delivery
Let us know if you have more information to add to this section.
Public Engagement in Science

• Visit of high school students to CNC laboratories | 31 January, CNC - Pólo I, Coimbra, Portugal



• Ciência às Seis | 31 January, Rómulo Centro de Ciência Viva, Coimbra, Portugal
o Participation of Cláudia Cavadas



• Saúde da Ciência às Pessoas | 8 January, Bencanta, Coimbra, Portugal
o Participation of Catarina Resende de Oliveira



• 4th PubhD Coimbra | 25 January, Aqui Base Tango, Coimbra, Portugal
o Participation of Sara Silva


• Do you already know that we are on social media?
You can find us on Facebook (@CNC UC), LinkedIn (@CNC UC), Instagram (@cnc.uc), Twitter (@cnc uc), Google+ (CNC UC) and YouTube (@CNCmediachannel). Please follow us so you can be always updated!




Visit of high school students to CNC laboratories
4th PubhD Coimbra
Let us know if you have more information to add to this section.
 
CNC on the Media

• News about Cláudia Cavadas participation in “Ciência às Seis” in Diário de Coimbra | 25 January, 2018

• News about the 4th edition of PubhD Coimbra with the participation of Sara Silva in Diário de Coimbra e Campeão das províncias | 25 January, 2018

• Opinion piece “Os primos (afastados) de Dolly” by João Ramalho-Santos in Público | 24 January, 2018

• News about the advanced course “Connecting the Researchers with the Society” in Diário de Coimbra | 21 January, 2018

• News about BEB Day in Diário das Beiras | 19 January, 2018

• Interview with Ricardo Vieira-Pires in Porto Canal | Mentes que Brilham | 14 January, 2017 [see here]

• News about the book “Neurociências” in News Farma Online | 9 January, 2018 [see here]


• Interview with Ricardo Vieira-Pires in Antena 1 | “As 7 Vidas do Ovo”, Ponto de Partida | 19 December, 2017 [see here]

• Interview with Ricardo Vieira-Pires in Antena 1 | “Investigação com ovos de aves e catálogo digital de arte equestre”, Os Dias do Futuro – Investigação e Inovação | 2 December, 2017 [see here]

Let us know if you have more information to add to this section.
Opportunities
Research Grants at CNC:

Two Post-Doctoral Fellowhsips:
o Project: ProSafe/0001/2016 “Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions” [see here]
Application deadline: 22 February, 2018

o Project: IF/00578/2014 “Molecular mechanisms in signaling selectivity of GPCRs” [see here]
Application deadline: 23 February, 2018




Let us know if you have more information to add to this section.

New faces | New roles
 

Mariana Palma
Post-Doctoral Research Fellow
Intermediary Metabolism
Ludgero Tavares
Post-Doctoral Research Fellow
Intermediary Metabolism
Mariana Laranjo
Master’s student
Neuronal Circuits and Behavior
Let us know if you have more information to add to this section.
Don’t miss out

• FameLab Portugal – International Science Communication Competition [see here]
o Important dates:
- 07-02-2018 (18h) – Application deadline
- 12-02-2018 e 13-02-2018 – Application Results
- 14-02-2018 (15:00) – Regional Final at Museu da Ciência, University of Coimbra

The Science Communication Office would like to encourage the researchers to participate in this competition and is available to provide any support during the preparation.





• GPS (Global Portuguese Scientists) – Online Network that connects Portuguese researchers around the world [see here]

The Science Communication Office would like to encourage the researchers to join this online scientific network.

 

FameLab Portugal
 
 
Let us know if you have more information to add to this section.
 
PhD Defenses
   
Sara Oliveira | 23 January, 2018
Thesis: "Carbon monoxide modulation of astrocytic viability following an ischemic injury"
Supervisors: Carlos Duarte and Helena Vieira (Faculdade Ciências Médicas, Universidade Nova de Lisboa)
 
 
Let us know if you have more information to add to this section.
 
 
 
Get Involved
 
CNC Seminars
Winter Series - Next talks

@CNC, UC - Pólo I, Coimbra – 14h

“Understanding Rickettsia-host interactions: the protease, the Trojan Horse and other stories”
Isaura Simões (CNC, UC-Biotech)
Host: Paula Veríssimo
February 2

“The involvement of astrocytes in cognitive processing”
João Filipe Oliveira (ICVS, University of Minho)
Host: Paula Agostinho
February 9

“Phospholipid matter in the regulation of neuron and glial function”
Pedro Brites (IBMC, i3S, University of Porto)
Host: Carlos Duarte
February 16

“Tau therapeutics in brain pathology: Exploring the link between depression and Alzheimer’s disease”
Ioannis Sotiropoulos (ICVS, University of Minho)
Host: Cláudia Pereira
February 23



 

@CNC / UC-Biotech, Cantanhede – 11h30

“Cross-linking/mass spectrometry strategies for applications in integrative structural biology”
Alexander Leitner (Institute of Molecular Systems Biology, ETH Zurich, Switzerland)
Host: Bruno Manadas
February 7

“Protein flexibility and selective promiscuity in rational drug design”
Carlos Camacho (School of Medicine, University of Pittsburgh, USA)
Host: Bruno Manadas
February 8

“Targeting a neurodegenerative disease: from benchtop to biotech”
Rui Brito (Coimbra Chemistry Center, University of Coimbra and BSIM therapeutics)
Host: Bruno Manadas
February 9

“Antibiotic detection using antibody engineering and immunoassays”
Xiaoying Zhang (College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, Shaanxi, china)
Host: Ricardo Pires
February 21

“Bacterial lipid rafts disassembly inhibits MRSA antibiotic resistance”
Daniel Lopez (National Centre for Biotechnology (CNB) & Spanish National Research Council (CSIC), Madrid, Spain)
Host: Ana Eulálio & Miguel Mano
February 28

 
PDBEB Advanced Courses 2017/2018 [see here]


Interactomics
February 5 - 9, 2018

Fighting infection
March 5 - 9, 2018


Aging: from cellular processes to the organism
March 12 - 16, 2018

Cardiovascular Sciences (Optional, FMUC)
March 19 - 23, 2018

Metabolism and Disease
March 26 - 30, 2018

Synapses, Neuronal Circuits and Behavior - Supported by FENS/IBRO-PERC
April 9 - 20, 2018
FENS and IBRO-PERC provides 4 stipends of 750 EUR for master and/or PhD students interested in attending this course.

Neurodegenerative disorders
April 23 - 27, 2018

Advanced Therapies
May 7 - 11, 2018

Drug Development
May 21 - June 1, 2018


 
 
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Credits

Contents:

Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Claudia Cavadas (Coordinator)
Design and Layout:

Lia Lopes and Ana Sofia Mergulhão