CNC Internal Newsletter
Issue 12 | June 2018
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  Publications May | June

Neurotensin, substance P, and insulin enhance cell migration.
Mouritzen MV, et al. J Pept Sci. 2018 Jun 25

A tutorial for developing a topical cream formulation based on the Quality by Design approach.
Simões A, et al. J Pharm Sci. 2018 Jun 20

Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity.
Balça-Silva J, et al. Exp Cell Res. 2018 Jun 11

A nanoformulation for the preferential accumulation in adult neurogenic niches.
Praça C, et al. J Control Release. 2018 Jun 15

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease.
Duarte AI, et al. Sci Rep. 2018 Jun 12

Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles.
Silva J, et al. AAPS PharmSciTech. 2018 Jun 4

Targeted alpha therapy using Radium-223: From physics to biological effects.
Marques IA, et al. Cancer Treat Rev. 2018 May 25

Modulation of Cellular Respiration by Endogenously Produced Nitric Oxide in Rat Hippocampal Slices.
Ledo A, et al. Methods Mol Biol. 2018

Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells.
Silva AM and Oliveira PJ. Methods Mol Biol. 2018
 
O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease.
Pinho TS, et al. Ageing Res Rev. 2018 May 19

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.
Costa S, et al. Exp Parasitol. 2018 Jul

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices.
Dias C, et al. Anal Biochem. 2018 Jun 15

Repurposing drugs for glioblastoma: From bench to bedside.
Basso J, et al. Cancer Lett. 2018 Aug 1

Cardoon-based rennets for cheese production.
Almeida CM and Simões I. Appl Microbiol Biotechnol. 2018 Jun

Is the chlorophyll derivative Zn(II)e6Me a good photosensitizer to be used in root canal disinfection?
Diogo P, et al. Photodiagnosis Photodyn Ther. 2018 Jun

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.
Cunha-Oliveira T, et al. Toxicol Appl Pharmacol. 2018 Jun 1

Preliminary Outcomes Report for CO2 Laser Assisted Electric-Acoustic Cochlear Implantation.
Stevens SM, et al. Otol Neurotol. 2018 Jun

Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Caetano-Oliveira R, et al. Pathophysiology. 2018 Jun

Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes.
Burgeiro A, et al. Biochim Biophys Acta. 2018 Jun

The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation.
Gonçalves A, et al. Biomed Pharmacother. 2018 Jun

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells.
Encarnação JC, et al. J Nutr Biochem. 2018 Jun

Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification.
Fernandes AR, et al. Colloids Surf B Biointerfaces. 2018 Jun 1

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma.
Mendes M, et al. Eur J Pharm Sci. 2018 May 30



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Awards / Honors

The “Sny2Psy" European Training Network led by CNC was approved under the Marie Curie Actions of Horizon 2020 and funded with 3.885 million euros to study neuropsychiatric diseases | June 2018
Coordination: Ana Luísa Carvalho
Researchers: Carlos Duarte, João Peça, Luísa Cortes, Paulo Pinheiro e Ramiro Almeida

“The Oxygen Club of California Young Investigator Award” - Joint Meeting of The Society for Free Radical Research International and The Society for Free Radical Research Europe | Lisbon, June 4-7, 2018 | Cândida Dias
Poster entitled "Age-dependent impairment of the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic mouse model of Alzheimer’s disease




“Sny2Psy" European Training Network
Oxygen Club of California Young Investigator Award
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Events @ CNC
Workshop “Finishing the PhD: how to turn anxiety into an actionable plan?” | June 20, UC-Biotech Gardens, Cantanhede
Organised by the PostDoctoral Representatives CNC.IBILI

 

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Scientific Meetings and Events


1º Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal | June 18, 2018 – Exploratório CCV Coimbra
Organized by CNC members



EIT Wild Card Tournament
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Public Engagement in Science

Brain Buskers

June 30 – Figueira da Foz, Coimbra
Ana Teresa Viegas, Sara Amaral

June 15 – Casa das Artes – Condomínio Criativo, Coimbra
Ana Teresa Viegas, Sara Amaral, Mireia Alemany and Tiago Reis


June 1 – Academia Ledman, Campos do Bolão (AAC), Coimbra
Ana Teresa Viegas, Fábio Sousa, Mireia Alemany, Rita Amado Dias, Sara Amaral, Tiago Reis



Brain Buskers - Figueira da Foz
Brain Buskers - Casa das Artes
Brain Buskers - Academia Ledman
Science at European University Games Coimbra 2018

Science Communication Chronicles about the relevance of exercise in our health in Diário de Coimbra every Tuesday and Friday until June 27

Collaboration with European University Games (EUG2018) [see here]
Science at European University Games
Let us know if you have more information to add to this section.
CNC on the Media

• News about the "Sny2Psy" European Training Network funded by Marie Curie Actions of Horizon 2020

o Visão | June 19 [see here]

o SIC Notícias | June 19 [see here]

o Shifter | June 19 [see here]

o Sapo | June 19 [see here]

o Sapo24 | June 19 [see here]

o RTP | June 19 [see here]

o PT Jornal | June 19 [see here]

o Postgraduate Medicine | June 19 [see here]

o Porto Canal | June 19 [see here]

o Notícias de Coimbra | June 19 [see here]

o Diário da Saúde | June 19 [see here]

o Destak | June 19 [see here]

o Correio da Manhã | June 19

o Comunidade Cultura e Arte | June 19 [see here]

o Atlas da Saúde | June 19 [see here]

o Índice.eu | June 20 [see here]

o Mundo Português | June 20 [see here]

o iPress Journal | June 20 [see here]

o Diário de Viseu | June 20 (in press)

o Diário de Coimbra | June 20 (in press)

o Diário As Beiras | June 20 (in press)

o Correio dos Açores | June 21 (in press)

o Alert | June 21 [see here]

o VerPortugal | June 22 [see here]

o Port.com | June 25 [see here]

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Opportunities
CNC Research Opportunities:


• Postdoctoral Fellowships:
o Scientific research and advanced training in the field of Protein Engineering / Computational Biochemistry [see here]
Application deadline: July 16, 2018

• Master’s Research Fellowships:
o Mechanisms underlying hemogenic induction in human fibroblasts [see here]
Application deadline: July 3, 2018

o Analysis of induced pluripotent stem cells (iPSC) and techniques of cellular and molecular biology, biochemistry and microscopy under Huntington's disease [see here]
Application deadline: July 6, 2018

o Preparation and isolation of subpopulations of cells in histological sections of human pancreas [see here]
Application deadline: July 9, 2018

o Scientific research and advanced training in the field of Protein Engineering / Computational Biochemistry [see here]
Application deadline: July 16, 2018

o Early Stage Researcher in the Foie Gras EU Training Network ESR9:
Research project on the mitochondrial biomarkers to predict hepatic surgery success at the Institute of Biomedical Research of Barcelona (IIBB-CSIC), Spain [see here]
Application deadline: July 15, 2018


Other Oportunities at CNC:

o Receptionist at UC-Biotech, Cantanhede
Application deadline: July 3, 2018





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Don’t miss out

GPS (Global Portuguese Scientists) – Online Network that connects Portuguese researchers around the world [see here]
The Science Communication Office would like to encourage the researchers to join this online scientific network.

New CNC Sequencing platform
The CNC Genome Sequencing Unit, Genoinseq, strengthened its responsiveness in NGS with the Illumina NextSeq sequencing platform. We thus extend our internal and external services in sequencing and bioinformatics (experimental design, sequencing, bioinformatics processing and analysis, results delivery in user-friendly formats).

Illumina sequencing platforms available at the core facility: MiSeq® and NextSeq®.

Application types:

    Genomics:

            - panels of genes and exomas

            - sequencing of small genomes and resequencing of genomes

    Transcriptomics:

            - total transcripts, RNA-Seq and small RNAs

    Metagenomics:

            - biodiversity and functional metagenomics of microbial communities

 For more information, please contact Conceição Egas (cegas@cnc.uc.pt), the CNC Genome Sequencing Unit - Genoinseq (genoinseq@biocant.pt) or call 231 249 17.

 
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Get Involved
CNC Seminars
Summer Series - Next talks

@CNC / UC-Biotech, Cantanhede – 11h30

“Artificial Intelligence in Structural Biology”
Irina Moreira (CNC, University of Coimbra)
Host: Lino Ferreira
July 11

“Peroxiredoxins, the thioredoxin system and redox signalling”
Christine Winterbourn (University of Otago, New Zealand)
Host: Armindo Salvador
July 12

“Finding targets and new therapies for retinal degenerative diseases”
Francisco Ambrósio (IBILI, University of Coimbra)
Host: Lino Ferreira
July 25

 





@CNC, UC - Pólo I, Coimbra – 14h

“From bedside to bench: the role of cholesteryl hemiesters in coronary artery disease”
Otília Vieira (CEDOC, NOVA University, Lisbon)
Host: Teresa Cruz
July 6

“Targeting solid tumors with lipid-based nanoparticles”
Nuno Fonseca (CNC, University of Coimbra)
Host: João Nuno Moreira
July 13

“Quantitative Biology of hydrogen peroxide signalling”
Fernando Antunes (Center of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon)
Host: Fernando Antunes
July 20


 

BRAIN BUSKERS


Science Communication project financed by the Biochemical Society (UK)
The Science Communication Office would like to encourage the researchers to join us in this initiative. To participate send an email to aviegas@cnc.uc.pt
SELFIE SCIENCE


Science Communication monthly videos
If you are passionate about science and if you would like to share your work, we encourage you to participate in this project! Please fill out the registration form [here]
 
 
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Credits

Contents:

Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Claudia Cavadas (Coordinator)
Design and Layout:

Lia Lopes and Ana Sofia Mergulhão