CNC Internal Newsletter
Issue 22 | April 2019
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Publications March | April

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.
Oliveira C, et al. Eur J Med Chem. 2019 Apr 17

Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields.
Dioli C, et al., Transl Psychiatry. 2019 Apr 26

Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection.
Curto P, et al, Front Cell Infect Microbiol. 2019 Apr 10

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.
Ferreira A, et al, Drug Chem Toxicol. 2019 Apr 25

Comparative proteomic analysis of saliva from dogs with and without obesity-related metabolic dysfuntion.
Lucena S, et al, J Proteomics. 2019 Apr 13

Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Magalhães-Novais S, et al, Autophagy. 2019 Apr 16

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.
Walter J, et al, Stem Cell Reports. 2019 Apr 2

Signaling by adenosine receptors-Homeostatic or allostatic control?
Cunha RA., PLoS Biol. 2019 Apr 5

The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis.
Serra D, et al, Mol Neurobiol. 2019 Apr 3

Evaluation of bioenergetic and mitochondrial function in liver transplantation.
Martins RM, et al, Clin Mol Hepatol. 2019 Mar 22.

A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods.
Bueschbell B, et al, Molecules. 2019 Mar 27

Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system.
Martínez-Rodríguez E, et al Brain Struct Funct. 2019 Mar 28

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.
Benfeito S, et al, Eur J Med Chem. 2019 Apr 1

Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain.
Moura LIF, et al, Brain Res Bull. 2019 Apr;

c-Src regulates Nrf2 activity through PKCδ after oxidant stimulus.
Fão L, et al, Biochim Biophys Acta Mol Cell Res. 2019 Apr;

Editorial commentary: Wanted: MicroRNAs to the aid of the diabetic foot.
Dalgaard LT, et al, Trends Cardiovasc Med. 2019 Apr

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation.
Moura J, et al, Sci Rep. 2019 Apr 9

Immune aging in diabetes and its implications in wound healing.
Moura J, et al, Clin Immunol. 2019 Mar

Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation.
Nunes C, et al, Food Funct. 2019 Mar 20

Corrigendum to "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells" [Atherosclerosis 205 (July 2009) 126-134].
Brito PM, et al, Atherosclerosis. 2019 Apr 10

Let us know if you have more information to add to this section.
Events & Meetings

Mycobacterial Glycoimmunology Joint Meeting
| April 5 @ Coimbra
Organized by Nuno Empadinhas

Health Week
Let us know if you have more information to add to this section.
Public Engagement in Science

Health week | April 24, 2019 @ Agrupamento de escolas da Lousã 
"Exercício Físico, Mitocôndrias e Fígados Gordos"
60 students
Participation of Paulo Oliveira

Selfie Science | April 26, 2019 @ UC-Biotech
Participation of Bibiana Silva [see here]

Ask "Always Seeking Knowledge" Researchers | April 30, 2019 @ UC-Biotech
Participation of Célia Aveleira [see here]

International Day of Immunology | April 29, 2019 @ UC-Biotech [see here]
60 people were reached
Participation of Catarina Silva, Filipe Pereira, Inês Caiado, Luís Oliveira, Manuela Ferreira, Marta Pinto, Miguel Mano, Paulo Rodrigues Santos, Susana Pedreiro and Teresa Cruz Rosete.

Selfie Science
Registration [here]
until May 24, 2019
Let us know if you have more information to add to this section.
CNC on the News

News about New model development to study autism:
TSF Online | April 4 [see here]
Sábado Online | April 4 [see here]
Saúde Online | April 4 [see here]
Sapo Online - Sapo Lifestyle Online | April 4 [see here]
Notícias Saúde Online | April 4 [see here]
Notícias de Coimbra Online | April 4 [see here]
Notícias ao Minuto Online | April 4 [see here]
Diário de Notícias Online | April 4 [see here]
Diário da Saúde Online | April 4 [see here]
Diário As Beiras Online | April 4 [see here]
Campeão das Províncias Online | April 4 [see here]
Atlas da Saúde Online | April 4 [see here]
Í Online | April 5 [see here]
Diário de Notícias da Madeira Online | April 5 [see here]
Diário As Beiras | April 5 (in Press)
Campeão das Províncias | April 11 (in Press)
Port.Com Online | April 15 [see here]


News about discovery about method that facilitate the diagnosis of neurodegenerative disorders:
Antena 1 | April 11
RTP 1 - Portugal em Direto | April 11
RTP 1 - Jornal da Tarde | April 13

News about protocol between CNC and CMC:
Notícias de Coimbra Online | April 25 [see here]

News about comentary of João Peça about the Power of Silence:
Visão | April 25 [see here]

News about comentary of João Ramalho-Santos about academic Careers:
Público | April 25 [see here]

Let us know if you have more information to add to this section.

CNC Research Opportunities:

14 Early Stage Researcher positions @ Syn2psy
Research Field: MSc degree in Biochemistry, Biology, Biological chemistry, Biomedical sciences, Pharmacy, Bio-informatics
Deadline: May 15, 2019
More Information:

1 BSc Fellowship @ CNC
Research Field: Biological sciences
Deadline: May 28, 2019
More information:

1 PhD position | Reference: INV JR 2019.48 n. º 029716
Health and Medical Sciences field [see here]
Application deadline: May 8, 2019

Let us know if you have more information to add to this section.

Don't miss Out

Below you can find the text and the publicizing rules to the eligibility of the research projects. You should use this text in all the materials that you publish under your project and CNC umbrella. 

The affiliation that all the CNC researchers should use is CNC - Center for Neuroscience and Cell Biology

EN: «This work was financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-##-####-FEDER-###### (insert acronym)* and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, under project[s] POCI-##-####-FEDER-######* and UID/NEU/04539/2019

The reference UID/NEU/04539/2019 is mandatory (Strategic Plan CNC.IBILI).  

*references of your funding project(s)

All the rules are available at:

CENTRO 2020:

Regarding the BID and individual fellowships (directly funded by FCT) the rules are available at:, article 35º.


PT: «[...] co-financiado por Fundos FEDER, através do Programa Operacional Regional Centro 2020 no âmbito do projecto CENTRO-##-####-FEDER-###### (inserir acrónimo)*, e através do Programa Operacional Competitividade e Internacionalização COMPETE 2020 e de fundos nacionais via FCT – Fundação para a Ciência e a Tecnologia, no âmbito do(s) projecto(s) POCI-##-####-FEDER-######  (inserir acrónimo(s))* e UID/NEU/04539/2019.»;

A referência UID/NEU/04539/2019 é obrigatória (Plano Estratégico CNC.IBILI)

*referências dos projetos que vos financiam 

As normas de Informação e Publicitação de Apoios para Beneficiários estão disponíveis em: 

CENTRO 2020:

Quanto às bolsas BID ou BD individuais (directamente atribuídas pela FCT), ver:, artigo 35º

Let us know if you have more information to add to this section.

Registrations for high-school
students to

Get Involved
CNC Seminars
Spring Series - Next talks

@CNC, Pólo I, Coimbra

"Design and optimization of potent, CNS-penetrant transthyretin stabilizers with a little help from Machine Learning"
Carlos Simões (Chief Technology Officer, BSIM Therapeutics)
Host: João Nuno Moreira
May 17, 14h00

"Micronutrient Sensing and Intestinal Immune Defence"
Manuela Ferreira (CNC, UC-Biotech & Champalimaud Foundation)
Host: Paulo Oliveira
May 31, 14h00

"Neuronal KCNQ channelopathies: a paradigm for rare developmental disorders highlighting therapeutic targets for more common diseases"
Maurizio Taglialatela (Department of Neuroscience, University of Naples Federico II, Naples, Italy)
Host: Ana Luísa Carvalho
June 21, 14h00

@CNC / UC-Biotech, Cantanhede

"Evolution and functional relevance of protein phosphorylation"
Pedro Beltrao (European Bioinformatics Institute EMBL-EBI)
Host: Bruno Manadas
May 19, 11h30

"Protease networks in skin inflammation and repair"
Ulrich auf dem Keller (European Bioinformatics Institute EMBL-EBI)
Host: Isaura Simões
May 10, 11h30

PDBEB Advanced Courses 2018/2019 [see here]

Registration by email to

PDBEB Courses 2018/2019
- Drug development
May 13 - 24, 2019

Let us know if you have more informations or any suggestions, to improve "Synergies"

Science Communication Office | Ana Teresa Viegas, João Cardoso, Lia Lopes, Sara Varela Amaral
Ask Researchers
International Day of Immunology
Mycobacterial Glycoimmunology joint meeting
Program [here
Registration [here]