CNC Internal Newsletter
Issue 20 | February 2019
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Publications January | February

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation.
Ali H,et al, Nat Commun. 2019 Feb 25

Claspin: From replication stress and DNA damage responses to cancer therapy.
Azenha D, et al, Adv Protein Chem Struct Biol. 2019;

Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia.
Alves R, et al, Med Oncol. 2019 Feb 22

Cardosin A Endocytosis Mediated by Integrin Leads to Lysosome Leakage and Apoptosis of Epithelial Cells.
Wu H, et al, Proteins. 2019 Feb 20.

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.
Benfeito S, et al, Eur J Med Chem. 2019 Feb 6

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.
Soares A, et al, J Exp Bot. 2019 Feb 19

A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin.
Pinto SMA, et al, Dalton Trans. 2019 Feb 18

RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3.
Nobrega C, et al, Hum Gene Ther. 2019 Feb 14

Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant.
Bento D, et al, Pharmaceutics. 2019 Feb 9

New insights on synaptic dysfunction in neuropsychiatric disorders.
Lima Caldeira G, et al, Curr Opin Neurobiol. 2019 Feb 8;

oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening.
Anjo SI, et al. Redox Biol. 2019 Jan 30

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.
Rajeshwari R, et al. Molecules. 2019 Feb 7

Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain.
Moura LIF, et al. Brain Res Bull. 2019 Feb 2


Atypical and nucellin-like aspartic proteases: emerging players in plant developmental processes and stress responses.
Soares A, et al, J Exp Bot. 2019 Jan 30

Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis.
Costa C, et al, J Control Release. 2019 Feb 10

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.
Ferreira LL, et al, Food Chem Toxicol. 2019 Feb

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease.
Grattagliano I, et al, Biochem Pharmacol. 2019 Feb

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Bajzikova M, et al, Cell Metab. 2019 Feb 5

Polymeric nanoengineered HBsAg DNA vaccine designed in combination with β‑glucan.
Soares E, et al, Int J Biol Macromol. 2019 Feb 1

Response to: Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema.
Campos A, et al, Graefes Arch Clin Exp Ophthalmol. 2019 Jan ??????

Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies.
Lebre F,et al,  J Pharm Pharmacol. 2019 Feb 25.

Immune aging in diabetes and its implications in wound healing
Moura J, et al,  Clin Immunol.  Epub 2019 Feb 5

Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of  Three Treadmill Running Protocols.
Melo KP, et al  Neurotox Res. 2019 Feb

Bioprocess decision support tool for scalable manufacture of extracellular vesicles.
Ng KS, et a, ,Biotechnol Bioeng. 2019 Feb.

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons.
Silva MM, Ret al,   Proc Natl Acad Sci U S A. 2019 Feb 26.

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives.
Alho DPS, et al,. Molecules. 2019 Feb 20

Plasmid-Mediated Colistin Resistance in Salmonella enterica: A Review.
Lima T, et al, Microorganisms. 2019 Feb 19

Let us know if you have more information to add to this section.

Concert tribute  dedicated to Manuela Grazina by the Orquestra Classica do Centro
February 23, 2019 @ Pavilhão Centro de Portugal, Coimbra

Concert tribute  dedicated to Manuela Grazina
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Public Engagement in Science
Escola Ciência Viva | February 18, 2019 @ Rómulo – Centro de Ciência Viva da Universidade de Coimbra

Communication activities with students from 3rd cycle education – collaboration with Rómulo.
Participation of Ana Catarina Pereira, Caren Janes, Fábio Sousa, Gonçalo Brites, Isabel Ferreira, Jessica De Pascale, João Calmeiro and Marta Pereira (Cell Signaling and Metabolism in Disease) | 30 children reached

Escola Ciência Viva 2019
Launch of the CNC Calendar 2019:
If you wish to purchase your calendar, ask for it at the Science Communication Office, or at the Secretariat of the Board of Directors (pólo I - 1st floor)
2019 CNC Calendar Cover
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CNC on the News

News about the Discovery of new targets to combat atypical mycobacteria:
Despertar Online  |  February 1 [see here]
Despertar | February 1 (in press)
News Farma Online - My Pneumologia Online | February 8 [see here]
Diário do Sul |  February 25 (in press)

News about  the participation of Manuela Grazina on “Pontos nos iii:
Diário de Coimbra | February 4 (in press)
Diários as Beias | February 6 (in press)

News about drawing contest “Dormir bem, envelhecer melhor”:
OvarNews Online | February 14 [see here
Magazine Serrano Online | February 15 [see here]
Funchal Notícias Online | February 18 [see here]

News about development of  technique with potential to treat leukemia:
TSF Online | February 22 [see here]
Saúde Online | February 22 [see here
Sapo Online - Sapo 24 Online | February 22 [see here]
PT Jornal Online | February 22 | [see here]
Observador Online | February 22 [see here]
Notícias de Coimbra Online | February 22 | [see here]
Notícias ao Minuto Online | Lifestyle ao Minuto | February 22 [see here
Notícias ao Minuto Online | País ao Minuto | February 22 [see here
Jogo Online  |  February 22 [see here
Impala Online | February 22 [see here]
Expresso Online | February 22 [see here]
Diário de Notícias Online | February 22 [see here
Diário As Beiras Online | February 22 [see here]
Campeão das Províncias Online | February 22 [see here]
Atlas da Saúde Online | February 22 [see here]
Diário de Coimbra Online | February 22 [see here
Diário de Coimbra  | February 23  (in press)
Diário As Beiras  |  February 23  (in press)
Í Online |  February 25 [see here]
ALERT® Online | February 26 [see here]

News about Caffeine that can halt development of Alzheimer:
Diário de Coimbra Online | February 27 [see here]
Diário de Coimbra  | February 27  (in press)

Let us know if you have more information to add to this section.

CNC Research Opportunities:

PhD Positions:

1 PhD position | Reference: INV JR 2019 Nº 44. 028060
Biological sciences field [see here]
Application deadline: March 14, 2019

1 PhD position | Reference: INV JR 2019.23/3 Nº 029999
Biological sciences field [see here]
Application deadline: March 18, 2019

1 PhD position | Reference: INV JR 2019.29/3 N º 028871
Biological sciences field [see here]
Application deadline: April 1, 2019

1 PhD position | Reference: INV JR 2019.45 N º 032309
Medical sciences field [see here]
Application deadline: April 10, 2019

Let us know if you have more information to add to this section.

Don't miss Out

2019 ScientistAtWork photo competition
Send us your very best science photos, and you could win a cash prize plus a year’s print and online subscription to Nature
Deadline March 17, 2019
More information: [see here]

Caixa Impulse 2019 projets Call
Deadline: March 18, 2019
More information: [see here]

World Sleep Day  | "Dormir Bem, Envelhecer Melhor"
March 15, 2019 | 14:30 - 18:00 @ Auditório do Conservatório de Música de Coimbra

Brain Awareness Week 2019

During Brain Awareness Week (BAW), a global campaign to increase public awareness of the progress and benefits of brain research, several events are yearly organized by CNC with the sponsorship of the Portuguese Society for Neuroscience (SPN), the Ciência Viva Agency, the Federation of European Neuroscience Societies (FENS), and The Dana Foundation.

Follow our activities in CNC social networks

INEO Start 2019 - Programa de Valorização de Resultados de I&D
Application Deadline: March 13, 2019

Session day & Place:
Polo II –  March 14, 2019 - 14h30 - 17h30 | Casa Costa Alemão,1st floor

Registration at:

Let us know
if you have more information to add to this section.

BAW 2019
Get Involved
CNC Seminars
Winter Series - Next talks

@CNC, Pólo I, Coimbra

"Computational Molecular Modelling of Cell Membranes"
Miguel Machuqueiro (Department of Chemistry and Biochemistry, University of Lisbon)
Host: Irina Moreira
March 1, 14h00

"The ATPase Inhibitory Factor 1: A double-edge sword? "
Jose M. Cuezva (Universidad Autónoma de Madrid, Spain)
Host: Paulo Oliveira
March 15, 14h00

"Cybersecurity risks and threats in the health sector "
Paulo Empadinhas (ENISA - EU Cyber Security Agency, Greece)
Host: Nuno Empadinhas
March 22, 14h00

"Regulation of neuronal connectivity and synaptic plasticity by endo- and fitocannabinoids"
Ana M. Sebastião (IMM and Faculty of Medicine, University of Lisbon)
Host: Carlos Duarte
March 29, 14h00

@CNC / UC-Biotech, Cantanhede

"Mitochondrial-Derived Peptides and their Roles in Diseases of Aging"
Pinchas Cohen (
Dean, USC Leonard Davis School of Gerontology, University of Southern California)
Host: Paulo Oliveira
March 6 , 10h00

"Computational Design of Functional Proteins for Biomedicine "
Bruno Correia (EPFL - École Polytechnique Fédérale de Lausanne)
Host: Ricardo Vieira-Pires/Pedro Castanheira (Immunethep)
March 6 , 11h30

"The CRISPR revolution"
Chase Beisel (Helmholtz Center for Infection Research, University of Würzburg, Germany)
Host: Isaura Simões
March 20 , 11h30

"Quantum GX2 MicroCT System for in vivo Imaging - from bone to heart"
Sasha (Alexandre) Belenkov (Applications Scientist PerkinElmer, Inc)
Host: Vilma Sardão
March 27, 11h30

PDBEB Advanced Courses 2018/2019 [see here]

PDBEB Courses 2018/2019 - Computational Biology
February 25 - March 1, 2019

PDBEB Courses 2018/2019 - Oncometabolism: Principles and Applications
March 11 - 15, 2019

PDBEB Courses 2018/2019 - Fighting infection
March 18 - 22, 2019

PDBEB Courses 2018/2019 - Synapse structure and function
March 25 - 29, 2019

PDBEB Courses 2018/2019 - Neuronal circuits & behavior
April 1 - 5, 2019

PDBEB Courses 2018/2019 - Neurodegenerative disorders
April 8 - 12, 2019

PDBEB Courses 2018/2019 - Advanced Therapies
April 22 - 26, 2019

PDBEB Courses 2018/2019 - Proteomics Approaches in Life Sciences
May 6 - 10, 2019

PDBEB Courses 2018/2019 - Drug development
May 13 - 24, 2019

Let us know if you have more informations or any suggestions, to improve "Synergies"

Science Communication Office | Ana Teresa Viegas, João Cardoso, Lia Lopes, Sara Varela Amaral