CNC Internal Newsletter
Issue 24 | June 2019
 
Publications May | June

5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities.
Figueiredo J, et al, Eur J Pharm Sci. 2019 Jun 21

Chitosan/poly(γ-glutamic acid) nanoparticles incorporating IFN-γ for immune response modulation in the context of colorectal cancer.
Castro F, et al, Biomater Sci. 2019 Jun 24

Heartfelt exercise: Physical exercise gets the cardiovascular system into shape.
C Pereira F., Rev Port Cardiol. 2019 Jun 18

Retinal texture biomarkers may help to discriminate between Alzheimer's, Parkinson's, and healthy controls.
Nunes A, et al, PLoS One. 2019 Jun 21

Corrigendum to "oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening" [Redox Biology (2019) 101130].
Anjo SI, et al, Redox Biol. 2019 Jun 17

Chicken egg yolk antibody (IgY) as diagnostics and therapeutics in parasitic infections - A review.
Diraviyam T, et al, Int J Biol Macromol. 2019 Jun 17

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson'Ss Disease.
Carmo M, et al, Br J Pharmacol. 2019 Jun 20

Developing cream formulations: renewed interest in an old problem.
Simões A, et all, J Pharm Sci. 2019 Jun 16.

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice.
Silva J, et al, Biomed Chromatogr. 2019 Jun 18

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons.
Afonso P, et al, Sci Signal. 2019 Jun 18

Early manifestation of myocardial involvement in systemic sclerosis.
Marques-Alves P, et al, Rev Port Cardiol. 2019 Apr

Hybrid nanostructured films for topical administration of simvastatin as coadjuvant treatment of melanoma.
Barone A, et al, J Pharm Sci. 2019 Jun 12

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors.
Lopes JP, et al, Biochem Pharmacol. 2019 Jun 12

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.
Nóbrega C, et all, Acta Neuropathol. 2019 Jun 14

The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits.
Serrenho D, et al, Front Cell Neurosci. 2019 May 27

Early Interaction of Alternaria infectoria Conidia with Macrophages.
Almeida MC, et al, Mycopathologia. 2019 Jun 11

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges.
Vitorino C, et al, Drug Discov Today. 2019 Jun 7

Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw.
Paulo S, et al, Materials (Basel). 2019 Jun 6

Neural correlates of anticipatory cardiac deceleration and its association with the speed of perceptual decision-making, in young and older adults.
Ribeiro MJ, et al, Neuroimage. 2019 Jun 5

Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling.
Santos-Alves E, et al, Mitochondrion. 2019 Jun 3

Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides.
Rodrigues ET, et al, Environ Pollut. 2019 May 27

Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction.
Aguilar C, et al, Microbiol Spectr. 2019 May

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review.
Gouveia F, et al, Anal Chim Acta. 2019 Oct 17

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.
Nóbrega C, et al, Acta Neuropathol. 2019 Jun 14

Histamine modulates hippocampal inflammation and neurogenesis in adult mice.
Saraiva C, et al, Sci Rep. 2019 Jun 10

Education modulates brain maintenance in presymptomatic frontotemporal dementia.
Gazzina S, et al, J Neurol Neurosurg Psychiatry. 2019 Jun 10.

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
Mullins N, et al, Am J Psychiatry. 2019 Jun 5

Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells.
Nunes C, et al, Chem Biol Interact. 2019 Jun 14

Parvoviral infection with systemic impact and renal consequences.
Mira FS, et al, BMJ Case Rep. 2019 Jun 8

Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling.
Santos-Alves E, et al, Mitochondrion. 2019 Jun 3

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
Gerardo H, et al, Scientific Reports. 2019 jun 24

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Events & Meetings

Opening lecture “Micobactérias: tuberculose e outras sérias” - Centennial Celebrations of Escola Secundária Gabriel Pereira | May 6, 2019 @ Auditório da Escola Secundária Gabriel Pereira, Évora [see here]

Nuno Empadinhas

 



 



 

Talk “Um admirável mundo novo de interacções microbioma-hospedeiro determinantes em saúde e doença” - III Jornadas de Cirurgia Colorectal | June 7, 2019 @ Monte Real Palace Hotel, Leiria [see here]

Nuno Empadinhas




StixCamp, Community development through science and arts | June 28-30, 2019 @ Castelo Rodrigo [see here]

Participation of Ana Santos Carvalho, João Cardoso and Sara Varela Amaral

Let us know if you have more information to add to this section.


Outreach Activities
| June 14, 2019 @ Centro Ciência Júnior Biocant, Cantanhede

- Participation of Getachew Debas Belew, Inês Filipa Cavaleiro, Liljana Georgievska and Mireia Alemany Pagès
30 students reached













Selfie Science
| June 25, 2019 [see here]

- Participation of Luís Oliveira

Centro Ciência Júnior Biocant | Students from Escola Técnico Profissional de Cantanhede

 









ASK (Always Seeking Knowledge) Researchers
| July 2, 2019 [see here]

- Participation of Ricardo Vieira-Pires


 

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CNC on the News

News about Foie Gras Project:
Visão | June 13 (in press)

News about the comic on Einstein's Theory of Relativity:
Público | June 5 (in press)
Público Online | June 5 [see here]

News about the diagnostic method for Obstructive Sleep Apnea developed by CNC researchers:
Exclusiva | May 31 (in press)
Jornal Médico. PT | May 31 (in press)
Líder | June 30 (in press)


News about the protocol between CNC and Escola Superior de Enfermagem de Coimbra:

Diário As Beiras | June 25 (in press)
Diário de Coimbra | June 25 (in press)
Diário As Beiras | June 24 (in press)
Diário de Coimbra | June 24 (in press)
Diário de Coimbra | June 23 (in press)

Commentary on silence retreats by a CNC Researcher:
Visão Online | June 1 [see here]

News about the international conference on Ageing in Coimbra organized by CNC reearchers:
Diário As Beiras | June 27 (in press)
Notícias de Coimbra Online | June 26 [see here]

News about the study on ageing by CNC researchers:
Público | June 28 (in press)
Público Online | June 28 [see here]

News about University researchers awarded by the European Diabetes Fundation:
Diário As Beiras | June 28 (in press)
Mundo Português Online | June 28 [see here]
Notícias de Coimbra Online | June 28 [see here]
Campeão das Províncias Online | June 27 [see here]
Notícias de Coimbra Online | June 27 [see here]

News about the international distinction of the Portuguese Sleep Day 2019:
Diário de Coimbra | June 19 (in press)
Notícias de Coimbra Online | June 18 [see here]

Let us know if you have more information to add to this section.
Opportunities

CNC Research Opportunities:

1 Doctoral Hiring
Job/Fellowship Reference: INV JR 2019.51 N º 029391
Main research field: Medical Sciences
Deadline: July 17, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=showAnuncioOportunities&jobId=114934&lang=pt&idc=1

1 Doctoral Hiring
Job/Fellowship Reference: INV JR 2019 Nº 52. 029297
Main research field: Medical Sciences
Deadline: July 19, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=showAnuncioOportunities&jobId=115024&idc=

1 Doctoral Hiring
Job/Fellowship Reference: INV JR 2019.42/2 Nº 030737
Main research field: Biological Sciences
Deadline: August 8, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=showAnuncioOportunities&jobId=115533&idc=1

 

 



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Awards
CNC Seminars
Summer Series - Next talks

@CNC, Pólo I, Coimbra


“Multidrug resistant tumours: searching for novel biomarkers, molecular targets and therapeutic tools”
M. Helena Vasconcelos (i3S/IPATIMUP, Faculdade de Farmácia, Universidade do Porto) Host: Amália Jurado
July 5, 14:00

“ATP-derived adenosine controls synaptic and memory dysfunction in β-amyloid models of Alzheimer’s disease”
João Pedro Lopes (CNC, Center for Neuroscience and Cell Biology)
Host: Ricardo Rodrigues
July 12, 14:00

“A RNA modification on the polyA tail promotes mRNA stability”
Luísa Miranda Figueiredo (Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa)
Host: Paulo Oliveira
July 26, 14:00


@CNC / UC-Biotech, Cantanhede

“Modeling and optimizing metabolism: applications in metabolic engineering and human health”
Miguel Rocha (University of Minho)
Host: Irina Moreira
July 3, 11:30

“Glycosylation in cancer biology and cellular communication: molecular mechanisms and clinical implications”
Celso Reis (i3S - Instituto de Investigação e Inovação em Saúde/IPATIMUP - Institute of Molecular Pathology and Immunology)
Host: Hugo Fernandes
July 17, 11:30

“TBA”
Clara Leandro (TechnoPhage, SA)
Host: Isaura Simões
July 24, 11:30





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Credits

Science Communication Office | Ana Teresa Viegas, João Cardoso, Lia Lopes, Sandra Pereira and Sara Varela Amaral
CNC | Nuno Empadinhas
Registration until July 31 [here
More Information [here]

Distinguished Activity Award from The World Sleep Day Committee:
[see here]

CNC and Portuguese Sleep Association

This award is meant to distinghish campaigns for the "2019 World Sleep Day Activity"

 

 



EIT Health PhD Translational Fellowship

Fábio Fiuza, PhD student
João Calmeiro, PhD student

This European award is destined to distinguish students who are interested in entrepreneurship with the tools needed to go from idea to real impact within the health technology field.
Each awarded student receives 5000€ for their research and a grant to attend a course at the University of Oxford.

 







Merit Award at Feira de Gastronomia e Artesanato da Freguesia de Almalaguês, Coimbra

Nuno Fonseca, CNC Researcher





 

 

 

 



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if you have more information to add to this section.

ASK Researchers | Ricardo Vieira-Pires
Selfie Science | Luís Oliveira
Fábio Fiuza and João Calmeiro
Campaign "2019 World Sleep Day Activity" distinguished Activity Award from The World Sleep Day Committee
Public Engagement in Science
Nuno Fonseca