CNC Internal Newsletter
Issue 23 | May 2019
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Publications April | May

Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain.
Ledo A, et al, Adv Exp Med Biol. 2019

High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital.
Tiago I, et al, Microbiol Resour Announc. 2019 May 23

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism.
Mouro FM, et al, Neuropharmacology. 2019 May 16

Post-translational modifications in brain health and disease.
Correia SC, et al, Biochim Biophys Acta Mol Basis Dis. 2019 May 15

The importance of determining circadian parameters in pharmacological studies.
Gaspar L, et al, Br J Pharmacol. 2019 May 16

Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.
Manso JA, et al, MBio. 2019 May 14

Molecular and Cellular Characterization of SIRT1 Allosteric Activators.
Schultz MB, et al, Methods Mol Biol. 2019

MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy.
Cardoso AMS, et al, Hum Mol Genet. 2019 May 14

Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections.
Carbone C, et al, Pharmaceutics. 2019 May 13

Polyphenols as food bioactive compounds in the context of Autism Spectrum Disorders: A critical mini-review.
Serra D, et al, Neurosci Biobehav Rev. 2019 May 11

Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration.
Moura J, et al, Cell Mol Immunol. 2019 May 9

What is the extracellular calcium concentration within brain synapses?: An Editorial for 'Ionized calcium in human cerebrospinal fluid and its influence on intrinsic and synaptic excitability of hippocampal pyramidal neurons in the rat'.
Lopes JP, et al, J Neurochem. 2019 May

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.
Carvalho C, et al, Adv Exp Med Biol. 2019

Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades.
Maciel E, et al, Cell Signal. 2019 May 2

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches.
Leandro K, et al, Pharmacol Res. 2019 Apr 30

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study.
Magalhães P, et al, Exp Clin Psychopharmacol. 2019 May 23

Let us know if you have more information to add to this section.
Events & Meetings

SciComPT 2019| May 30-31 @ Aveiro

Oral Presentations:
Ana Teresa Viegas, João Cardoso and Sara Varela Amaral | Brain Buskers: ciência em espaços públicos
Mireia Alemany-Pagè, João Ramalho-Santos and Anabela Marisa Azul | Defatting for a better life - a participatory research approach to communicate metabolic disorders

Debate:
João Cardoso (CNC), Maria João Leão (Maratona da Saúde), Patrícia Correia (Champalimaud Foundation), Sara Varela Amaral (CNC) and Vera Novais (Observador) | Comunicação de ciência: Como chegámos aqui?
Catarina Ramos (Champalimaud Foundation), Inês Domigues (IMM), Júlio Borlido (i3s) and Sara Varela Amaral (CNC) | Estratégias de comunicação de ciência vistas de dentro

Poster Presentation:
Ana Santos-Carvalho, Ana Teresa Barros-Viegas, Daniela Cordeiro, Fábio Sousa, João Cardoso, Miguel Ferreira and Sara Varela Amaral | PubhD Coimbra - três doutorandos à conversa num bar


XVI Meeting of the Portuguese Society for Neuroscience | May 30 – June 1, 2019 @ Lisbon

Chairs:
Ricardo Rodrigues, João Peça, Ana Cristina Rego

Invited Speaker:
Luís Pereira de Almeida | Machado-Joseph disease: from gene to therapeutic strategies

Oral Presentations:
Daniel Henriques | Human IPSC-derived neuroepithelial stem cells for cell-based therapies in Machado-Joseph disease
Ana Moreira de Sá | Blockade of adenosine A2A receptors improves motor learning and grip strength in an Angelman Syndrome mouse model
Miranda Mele | Alteration of GABAa receptor trafficking in status epilepticus
Mariline M. Silva | Activity regulated miRNA-186-5p controls homeostatic processes in hippocampal neurons
Sara M. Lopes | Permanent inactivation of the atxn3 gene: a possible therapeutic approach for Machado-Joseph disease
Joana R. Guedes | IL-4 skews the microglial developmental program during cerebellar maturation
Diana Lobo | Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph disease: results from human and MJD mouse samples
Ana Patrícia Simões | Adenosine A2A receptors control the extinction of fear memories
Sónia Patrícia Duarte | Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models

Poster Presentations:

Ricardo J. Rodrigues | P2 receptors control the migration of medial ganglionic eminence-derived interneurons
Catarina M. Seabra | Protean - production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorder
Pasqualino De Luca | BDNF increases synaptic expression of GluN2B-containing NMDAr in cultured hippocampal neuron
Rafael S. Carvalho | Regulation of NMDA receptor surface dynamics by BDNF in cultured hippocampal neurons
Ana Moreira de Sá | Blockade of adenosine A2A receptors improves motor learning and grip strength in an Angelman Syndrome mouse model
Liliana Mendonça | Cyp46A1- gene therapy alleviates Machado-Joseph Disease
Ana Vasconcelos-Ferreira | Reinstating levels of dysregulated autophagy-associated transcripts alleviates europathology and motor impairments of mouse models of Machado-Joseph Disease
Vanessa Lourenço | Adenosine A2A receptors in the basolateral amygdala modulate fear extinction
Ivan L. Salazar | Novel cerebrospinal fluid biomarkers of multiple sclerosis
Cátia Santa | Analysis of the quantitative proteomic signature in PBMCS of first-episode psychosis patients
Dina Pereira | The role of ageing in polyglutamine-induced neurodegeneration: a study in Machado-Joseph disease models
Sandra I. Anjo | PBMCS as a potential source of biomarkers in neurodegenerative diseases – preliminary study
Rui J. Nobre | Non-invasive and allele-specific silencing therapy for polyglutamine disorders: the case of Machado-Joseph disease/spinocerebellar ataxia type 3
Ildete L. Ferreira | Postsynaptic decrease of SAPAP3 scaffold protein in Huntington’s disease
Daniela Marinho | Role of class I histone deacetylase inhibitors in cell and animal models of Alzheimer’s disease
João M. M. Rocha | Cortical neuronal migration entails A2A receptor-driven neuronal polarization and axon formation
Joana M. Marques | Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis
Margarida Beatriz | Correction of mutant huntingtin gene ameliorates mitochondrial function in pluripotent and neural stem cells derived from Huntington’s disease patients
Rita Perfeito | Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson’s disease cell models
Ana Cristina Rego | C-SRC regulates NRF2 activity through PKCδ after oxidant stimulus
Ricardo Moreira
| Investigation of mutant ataxin-3 spreading in Machado-Joseph disease
Catarina Oliveira Miranda | Sustainable phenotypic ameliorations in Machado-Joseph disease/spinocerebellar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton magnetic resonance spectroscopy biomarkers
Joana R. Guedes | IL-4 skews the microglial developmental program during cerebellar maturation
Daniela Madeira | Alterations in connexin 43 triggered by amyloid-β in astrocytes: modulation by adenosine A2A receptors
Cátia Lopes | Astroglia control synaptic plasticity in an animal model of Alzheimer's disease
Liliana Dias | Amyloid-β peptides affect astrocytic Ca2+ dynamics and exocytotic gliotransmitter release
Diana Lobo | Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph disease: results from human and MJD mouse samples




SciComPT 2019 | Ana Teresa Viegas
SciComPT 2019 | Discussion Panel
SPN | Diana Lobo
SPN | Catarina Seabra
SPN | Joana Guedes
Let us know if you have more information to add to this section.
Public Engagement in Science

Escola Ciência Viva @ Rómulo - Centro de Ciência Viva, University of Coimbra

- Participation of Ana Duarte, Cristina Carvalho, Débora Mena, Maria Inês Alves and Sónia Correia | May 6, 2019
15 students reached

- Participation of Catarina Miranda, David Ramos, Inês Barros, Maria Inês Martins and Sónia Duarte | May 13, 2019
15 students reached

- Participation of Joana Marques and Ricardo Rodrigues | May 20, 2019
23 students reached

- Participation of Ana Ledo and Bárbara Rocha | May 27, 2019
20 students reached


Outreach activities | May 21, 2019 @ Escola Básica S. Miguel de Nevogilde, Porto
- Participation of Ramiro Almeida
27 students reached


Talk about Autism Spectrum Disorders | May 28, 2019 @ Agrupamento de Escolas de Mira (1º and 2º CEB)
- Participation of Mariana Laranjo and Tiago Reis
80 students reached


Outreach activities | May 28, 2019 @ Escola Sede de Agrupamento Rio Novo de Príncipe, Cacia, Aveiro
- Participation of Ana Rita Álvaro, Ana Santos Carvalho, Bárbara Santos and Laetitia Gaspar
75 students reached


Workshop "Dar Corpo ao Cérebro" | May 29, 2019 @ Centro de Artes Águeda, Águeda
- Participation of Ana Santos Carvalho, Bárbara Santos e Laetitia Gaspar
129 people reached


MICRODay | May 22, 2019 @ CNC polo I [see here]
- Participation of Ana Rafaela Oliveira, Catarina Seabra, Gladys Caldeira, Luísa Cortes, Miranda Mele, Nuno Beltrão and Tatiana Catarino
25 people were reached



Selfie Science | May 28, 2019 [see here]
- Participation of Fábio Sousa


ASK (Always Seeking Knowledge) Researchers
| June 4, 2019 [see here]
- Participation of Sandra Amaral


MICRODay
MICRODay
Selfie Science | Fábio Sousa
Ask Researchers | Sandra Amaral
Let us know if you have more information to add to this section.
CNC on the News

News about ESCI Congress:
Notícias de Coimbra Online | May 2 [see here]
Diário As Beiras | May 3 (in press)

Despertar Online | May 10 [see here]
Desperate | May 10 (in press)
Diário As Beiras | May 21 [see here]
Tome Nota | May 21 [see here]

News about Inovator System of Sleep Apnea diagnosis at Coimbra:
TV Europa Online | May 7 [see here]
Terras de Sicó Online | May 7 [see here]
Notícias de Coimbra Online | May 7 [see here]
Jornal Médico.pt Online | May 7 [see here]
Diário de Notícias Online | May 7 [see here]
Diário As Beiras Online | May 7 (in press)
Índice.eu Online | May 8 [see here]
Saúde Online | May 8 [see here]
Netfarma Online | May 8 [see here]
Medjournal Online | May 8 [see here]
Diário de Coimbra (PT) | May 8 (in press)
Diário As Beiras (PT) | May 8 (in press)
Saúde Online | May 9 [see here]
Saúde Online | May 10 [see here]
News Farma Online - My Pneumologia Online | May 10 [see here]
Atlas da Saúde Online | May 13 [see here]
TSF Online | May 16 [see here]
Bairrada Informação Online  | May 21 [see here]
Antena 1 | May 21 [see here]
RTP1 | May 22 [see here]


News about Research at the University of Coimbra that demonstrates the impact of “recycling” and “quality control” of stem cells
Terras de Sicó Online | May 16 [see here]
Sapo Online - Sapo Lifestyle Online | May 16 [see here]
Sapo Online - Sapo 24 Online | May 16 [see here]
Notícias ao Minuto Online | May 16 [see here
Netfarma Online | May 16 [see here]
Diário de Notícias Online | May 16 [see here]
Notícias de Coimbra Online | May 16 [see here]
Campeão das Províncias Online | May 16 [see here]
Diário de Notícias da Madeira Online | May 17 [see here]
Diário as Beiras | May 17 (in press)
Diário de Coimbra | May 17 (in press)
Saúde Online | May 20 [see here]
ALERT® Online | May 21 [see here]
Campeão da Provincias | May 23 (in press)

News about National Day of Microscopy
Notícias de Coimbra Online | May 20 [see here]
Diário de Coimbra | May 22 (in press)
Diário as Beiras | May 22 (in press)
Diário de Coimbra | May 23 (in press)


Let us know if you have more information to add to this section.
Opportunities

CNC Research Opportunities:


1 MSc Fellowship
Job/Fellowship Reference: BIM-PAC CANCEL_STEM/2019
Main research field: Biological sciences
Deadline: June 21, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114629

1 MSc Fellowship
Job/Fellowship Reference: BIM: POCI-01-0145-FEDER-029089
Main research field: Biological sciences
Deadline: June 26, 2019
More information: www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114729

1 MSc Fellowship
Job/Fellowship Reference: BIM: EN/Med/0005/2015
Main research field: Pharmaceutical Sciences
Deadline: July 3, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114945

1 Doctoral hiring
Job/Fellowship Reference: INV JR 2019 Nº 44. 028060/2
Main research field: Biological sciences
Deadline: June 21, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114187

1 Doctoral hiring
Job/Fellowship Reference: INV JR 2019 Nº 49 nº 029621
Main research field: Medical sciences
Deadline: June 27, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114358

1 Doctoral hiring
Job/Fellowship Reference: INV JR 2019 50 N º 032316
Main research field: Medical sciences
Deadline: July 1, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114424

1 Doctoral Hiring
Job/Fellowship Reference: INV JR 2019.51 N º 029391
Main research field: Medical Sciences
Deadline: July 17, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=global&jobId=114945

1 Doctoral Hiring
Job/Fellowship Reference: INV JR 2019 Nº 52. 029297
Main research field: Medical Sciences
Deadline: July 19, 2019
More information: http://www.eracareers.pt/opportunities/index.aspx?task=showAnuncioOportunities&jobId=115024&idc=1



Let us know if you have more information to add to this section.

 




Get Involved
CNC Seminars
Spring Series - Next talks

@CNC, Pólo I, Coimbra


"Neuronal KCNQ channelopathies: a paradigm for rare developmental disorders highlighting therapeutic targets for more common diseases"
Maurizio Taglialatela (Department of Neuroscience, University of Naples Federico II, Naples, Italy)
Host: Ana Luísa Carvalho
June 21, 14h00


@CNC / UC-Biotech, Cantanhede


"Metabotropic receptors as a common dysfunction in neurodevelopmental disorders"
João Peça (CNC-Center for Neuroscience and Cell Biology)
Host: Lino Ferreira
June 19, 11h30

Registration until July 31 [here
More information [here]
More Information [here]
Let us know if you have more informations or any suggestions, to improve "Synergies"
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Credits

Science Communication Office | Ana Teresa Viegas, João Cardoso, Lia Lopes, Sara Varela Amaral