Neurology Research
Luis Cunha, Isabel Santana (FMUC, CHUC); Inês Baldeiras, Catarina Oliveira (FMUC, CNC)
Studies on Neurodegenerative Disorders
Biomarkers for the early diagnosis of Alzheimer´s Disease (AD) is one of our main areas of interest. In this context, under the scope of the project PIC/IC/83206/2007, we have determined the Cerebrospinal Fluid (CSF) levels of Aβ42, t-tau and p-tau in a group of 170 AD patients, 135 controls (100 FTLD patients and 35 controls without cognitive impairment) and 90 MCI patients.

First, a cross-sectional study involving non-demented controls and AD patients was done in order to establish cut-off values for the CSF biomarkers and sensitivity and specificity figures, to differentiate between AD and controls were calculated. All markers, and ratios between them (t-tau/Aβ42 and Aβ42/p-tau), exhibited areas under the ROC curves (AUC) above 0.80, and the ratio Aβ42/p-tau resulted in sensitivity and specificity levels above 85%. Based on the above analysis, we established criteria for CSF profile classification, assuming that a typical CSF-AD profile would represent a high-risk of progression to AD in MCI patients. Out of the 90 patients diagnosed with MCI, 46 had a CSF profile typical of AD (MCI-AD, p>0.05 for all CSF markers), presented with lower MMSE scores and higher ADAS-Cog scores than MCI-nonAD patients and ApoE-ε4 allele distribution was significantly increased in the MCI-AD group (Baldeiras I, Santana I, Garrucho MH, Pascoal R, Lemos R, Santiago B, Oliveira CR. Sinapse 2012;12 (2):14-22).
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Publications
Inês Baldeiras, Isabel Santana, Maria Helena Garrucho, Rui Pascoal, Raquel Lemos, Beatriz Santiago, Catarina Resende de Oliveira .(2012). CSF biomarkers for the early diagnosis of Alzheimer’s disease in a routine clinical setting – the first Portuguese study. Sinapse;12 (2):14-22.

Casimiro C, Martins J, Parreira T, Baldeiras I, Ribeiro H, Batista S, Machado E, Maduro A, Rebelo O, Freitas P .(2012). Bilateral hyperintensity of the pulvinar and dorsomedial nucleus of the thalamus in sporadic Creutzfeldt-Jakob disease. Acta Med Port. 25 (S1):41-44.

Ferreiro E, Baldeiras I, Ferreira L, Costa R, Rego AC, Pereira CF, Oliveira CR (2012). Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol 2012:735206. Epub Jun 4.

Ribeiro CA, Santana I, Oliveira CR, Baldeiras I, Moreira J, Saraiva MJ, Cardoso I. (2012).Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation. Curr Alzheimer Res; 9 (8):881-889.

Carvalho C, Cardoso S, Correia SC, Santos RX, Santos MS, Baldeiras I, Oliveira CR, Moreira PI. (2012). Metabolic Alterations Induced by Sucrose Intake and Alzheimer's Disease Promote Similar Brain Mitochondrial Abnormalities. Diabetes; 61 (5):1234-1242.

Freitas M, Baldeiras I, Proença T, Alves V, Mota-Pinto A, Sarmento-Ribeiro A (2012). Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase. FEBS Open Bio; 2:119-128.

Branco AF, Sampaio SF, Moreira AC, Holy J, Wallace KB, Baldeiras I, Oliveira PJ, Sardão VA (2012). Differentiation-Dependent Doxorubicin Toxicity on H9c2 Cardiomyoblasts. Cardiovascular Toxicology; 12 (4):326-340. .

Cardoso S, Santos RX, Correia SC, Carvalho C, Santos MS, Baldeiras I, Oliveira CR, Moreira PI (2012). Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance. Neurobiol Dis.; 24(49C):1-12.
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