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| Arthritis research: inflammation |
| Fernando Judas (HUC), Alexandrina Mendes (CNC), Celeste Lopes (CNC) |
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| In collaboration with the Orthopaedic and Bone Bank Departments of the University Hospital, we are currently developing the projects entitled “Regulation of the response of normal and arthritic chondrocytes to pro- and anti-inflammatory cytokines” and “Evaluation of chondrocyte viability and metabolic activity in different conditions of cryopreservation of osteochondral allografts” using normal and osteoarthritic human articular chondrocytes. The first project aims at elucidating the role of the NOS isoforms in the regulation of the chondrocyte response to pro- and anti-inflammatory cytokines and at identifying molecular targets that can lead to new therapeutic strategies to arthritic diseases. The major objective of the second project is to develop a method for the cryopreservation of osteochondral allografts that maintains chondrocyte viability and metabolic activity and that is suitable for use at the Bone Bank Department of the University Hospital. The results of these two projects are expected, respectively, to identify molecular mechanisms that can be translated into new therapeutic strategies for arthritic diseases and to improve the survival rate of implanted osteochondral allografts, thus direct and positively affecting the clinical outcome. |
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| PUBLICATIONS |
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| Rosa S.C., Teixeira L., Lopes C., Mendes A.F. (2006). Chondrocyte viability in fresh and frozen large human osteochondral allografts: effect of cryoprotective agents. Transp. Proc. (in press) |
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| Mendes A.F., Rosa S.C., Judas F., Lopes M.C. (2006). Chondrocyte Viability in Human Tibial Plateaus Cryopreserved with the Natural Glycosylated Hydroquinone, Arbutin. Osteoarthritis Cartilage. 14 (supp.B): P385. |
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| Rosa S.C., Mobasheri A., Lopes M.C., Mendes A.F. (2006). Glucose transport in immortalized human chondrocytes (C-28/I2) in normoxia and hypoxia. Osteoarthritis Cartilage. 14 (supp.B): P179. |
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