Dermatology Research
Margarida Gonçalo (HUC), Américo Figueiredo (FMUC, HUC), Teresa Cruz (FFUC, CNC), Bruno Neves (UA), Celeste Lopes (FFUC, CNC)
Allergic contact dermatitis (ACD) and delayed exanthematic drug eruptions are T-cell mediated skin reactions. Pathomechanisms are not fully understood, namely in which considers antigen presentation.

As shown in previous work by our group, contact allergens directly activate intracellular signalling pathways in dendritic cells (DC) in vitro and modify the expression of adhesion and activation molecules, cytokine and chemokine receptors and the release of cytokines and chemokines that promote DC maturation and facilitate antigen presentation and T cell sensitization.

Epicutaneous skin tests, as those used for the diagnosis of ACD, are often positive in drug eruptions, suggesting that skin DC can also be involved in the antigen presentation of systemic drugs. It is our objective to evaluate if DC suffer the same activation and maturation process in the presence of systemic drugs as they do in the presence of contact allergens.

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Publications
Amaro C, Cravo M, Fernandes C, Santos R, Gonçalo M (2012). Undisclosed methyldibromo glutaronitrile causing allergic contact dermatitis. in a NSAID cream. Contact Dermatitis, 67(3):173-4.

Andrade P, Barros L and Gonçalo M (2012). Type 1 IgE mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics An Bras Dermatol., 87:917-9

Alistair C Kerr et al. (2012). A European multi-centre photopatch test study (EMCPTTS), Br J Dermatol., 166(5):10029.

Brinca A, Teixeira V, Gonçalo M, Tellechea O. (2012). A large pigmented lesion mimicking malignat melanoma. Clin Exp Dermatol.:37:817-8.

Gonçalo M and Bruynzeel D (2012). Mechanisms in cutaneous drug hypersensitivity reactions. In Dermatotoxicology. 8th Ed. CRC Press. Boca Raton, Wilhelm K-P, Zhai H, Maibach HI (Eds). Cap. 9, Pg 78-92.

Gonçalo M .(2012). Phototoxic dermatitis In Kanerva’s Occupational Dermatology. 2nd Ed. Springer-Verlag, Berlin Heidelberg. Rustemeyer T, Elsner P, John S-M, Maibach H-I (Eds). Cap. 15, Pag 147-160.

Gonçalo M .(2012). Poultry processors. Tattoo artists. In Kanerva’s Occupational Dermatology. 2nd Ed. Springer-Verlag, Berlin Heidelberg. Rustemeyer T, Elsner P, John S-M, Maibach H-I (Eds). (Cap. 182 and 194) Pg 1461-2 and 1709-11.

Gonçalo M, Cézar-Pires M .(2012). Reacções adversas a cosmecêuticos. . In Tratado Internacional de Cosmecêuticos. Adilson Costa (Ed) Editora Guanabara Koogan Ltda. Cap. 26, Pg 273-283.

Neide Pereira, A Brinca, M Manuel Brites, MJ Julião, O Tellechea, M Gonçalo .(2012). Pityriasis lichenoides et varioliformis acute: case report and review of the literature. Case Rep Dermatol., Jan:4(1):61-5

Serra D, Ramos L, Brinca A, Gonçalo M .(2012). Acute generalized exanthematous pustulosis associated with acyclovir, confirmed by patch testing. Dermatitis: 23:99-10.

Serra D, Amaro P, Gonçalo M, Silva M, Ferrando B, Pasini B, Figueiredo A .(2012). Gastric leiomyoma and hyperplastic polyposis coli in a patient with multiple cutaneous and uterine leiomyomatosis. J Cutan Med Surg.:16(3):20811.

Svedman C et al. (2012). Follow-up of the monitored levels of preservative sensitivity in Europe. Overview of the years 2001-2008. Contact Dermatitis, 67:312-4.
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