Arthritis Research
Fernando Judas (HUC, FMUC), Alexandrina Mendes (FFUC, CNC) Carlos Cavaleiro (FFUC, CEF), Ali Mobasheri (U. Nottingham,U.K.), Celeste Lopes (FFUC, CNC)
Inflammation and osteoarthritis
In collaboration with the Orthopedic and Bone Bank Departments of HUC, we are using normal and osteoarthritic (OA) human articular cartilage and chondrocytes to identify 1) cellular and molecular mechanisms relevant in OA pathogenesis that can be translated into new therapeutic strategies, and 2) compounds in essential oils with potential anti-osteoarthritic activity. Two essential oils were found to simultaneously inhibit catabolic and inflammatory responses in human chondrocytes, which is strongly predictive of potential anti-osteoarthritic properties. Pharmacological characterization identified some monoterpene compounds as the active ingredients of those essential oils. Further pharmacological characterization is underway to establish the relative potency of the active compounds.
Mobasheri A, Lewis R, Ferreira-Mendes A, Rufino A, Dart C, Barrett-Jolley R. (2012). Potassium channels in articular chondrocytes. Channels; 6:1-10.

Rufino AT, Cavaleiro C, Judas F, Salgueiro L, Lopes MC, Mendes AF. (2012) The essential oil of Eryngium duriaei subsp. juresianum inhibits IL-1β induced NF-kB and MAPK activation in human chondrocytes. Osteoarthritis Cartilage.; 20 (Suppl. 1): S290 (P580).

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