Research in brain tumors
Alberto Orfão (CSIC, University Salamanca), Maria Dolores Tabernero (University Hospital, Salamanca), Hermínio Tão (HUC), Olinda Rebelo (HUC), Marcos Barbosa (FMUC, HUC), Anália do Carmo (CNC), M. Celeste Lopes (FFUC, CNC)
Gliomas are tumors derived from glial cells of brain and they account for more than 70% of all neoplasms of the central nervous system and vary considerably in morphology, localization, genetic alterations and response to therapy.

The project entitled “Genetic Heterogeneity in Gliomas: correlation with clinical and biological features of the disease” is being developed in collaboration with Neuropathology Laboratory and Neurosurgery Service of the University Hospital of Coimbra and with Center for Cancer Research of Salamanca. In this project, we first analysed the incidence of numerical/structural abnormalities of chromosomes in a group of 90 human gliomas by using interphase fluorescence in situ hybridization (iFISH). Overall, iFISH analysis revealed complex and heterogeneous cytogenetic profiles in this type of tumors with distinct pathways of clonal evolution being detected, which were associated with both the histopathological subtype and the grade of the tumor.
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Publications
Balça-Silva J, Matias D, Carmo A, Sarmento-Ribeiro A, Lopes MC. (2012). Evaluation of the role of temozolomide in glioma cell line. Acta Méd Port. January PP-17.

Crespo I, Tão H, Nieto AB, Rebelo O, Domingues P, Vital AL, Patino MC, Barbosa M, Lopes MC, Oliveira CR, Orfao A, Tabernero MD .(2012). Amplified and homozygously deleted genes in glioblastoma: impact on gene expression levels. PLOS ONE, 7(9): 1-11.

Domingues PH , Teodósio C , Ortiz J , Sousa P , Otero A , Maillo A, Bárcena P, García-Macias MC, Lopes MC , Oliveira CR, Orfao A, Tabernero MD .(2012). Immunophenotypic identification and characterization of tumor cells and infiltrating cell populations in meningiomas. Am J Pathol.;181:1749-61.

Matias D, Balça-Silva J, Carmo A, Sarmento-Ribeiro A, Lopes MC. (2012). Glioma cell motility is modulated by CXCL12/CXCR4. Acta Méd Port. January PP-17.

Tabernero MD, Maíllo A, Nieto AB, Diez-Tascón C, Lara M, Sousa P, Otero A, Castrillo A, Patino-Alonso Mdel C, Espinosa A, Mackintosh C, de Alava E, Orfao A. (2012). Delineation of commonly deleted chromosomal regions in meningiomas by high-density single nucleotide polymorphism genotyping arrays. Genes, Chromosomes and Cancer: 51: 606–617
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