Anaesthesia in Dental Medicine with Local Infiltrative Anaesthetic Technique Versus Diploe Anaesthesia Delivery Systems: Efficacy and Behaviour, an Experimental Study.
Marques-Ferreira M et al. Acta Med Port. 2017 Dec 29

Paraben degradation using catalytic ozonation over volcanic rocks.
Gomes JF et al. Environ Sci Pollut Res Int. 2017 Dec 23

Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin - Thioredoxin system. 1. Understanding commonalities and differences among cell types.
Selvaggio G at el. Redox Biol. 2017 Dec 21

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.
Teixeira J et al. Redox Biol. 2017 Dec 30

First Molecular Characterization of Hypoderma actaeon in Cattle and Red Deer (Cervus elaphus) in Portugal.
Ahmed H et al. Korean J Parasitol. 2017 Dec

Paraben degradation using catalytic ozonation over volcanic rocks.
Gomes JF, et al. Environ Sci Pollut Res Int. 2017 Dec 23

The neurobiological mechanisms of physical exercise in methamphetamine addiction.
Morais APD, et al. CNS Neurosci Ther. 2017 Dec 20

Effects of resistance exercise on endothelial progenitor cell mobilization in women.
Ribeiro F, et al. Sci Rep. 2017 Dec 19

Occipital Blood brain barrier permeability is an independent predictor of visual outcome in type 2 diabetics, irrespective of the retinal barrier: a longitudinal study.
Abuhaiba SI, et al. J Neuroendocrinol. 2017 Dec 16

Computational modeling in glioblastoma: from the prediction of blood-brain barrier permeability to the simulation of tumor behavior.
Miranda A, et al. Future Med Chem. 2018 Dec 13

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.
Leal G, et al. eNeuro. 2017 Dec 12

Control of Huntington´s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.
Hachigian LJ, et al. Cell Rep. 2017 Dec 5

Intracellular delivery of more than one protein with spatio-temporal control.
Lino MM, et al. Nanoscale. 2017 Dec 7

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice.
Marques AP, et al. Biochim Biophys Acta. 2017 Dec 4

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.
Figueiredo J, et al. Eur J Med Chem. Nov 27.

Mammospheres of hormonal receptor positive breast cancer diverge to triple-negative phenotype.
Laranjo M, et al. Breast. 2017 Nov 25

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels.
Carvalho Pereira A, et al. J Autism Dev Disord. 2017 Nov 24

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.
Hiremathad A, et al. J Inorg Biochem. 2017 Nov 21

Targeting cancer stem cells and non-stem cancer cells: the potential of lipid-based nanoparticles.
Cruz AF, et al. Curr Pharm Des. 2017 Nov 14

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels.
Carvalho Pereira A, et al. J Autism Dev Disord. 2017 Nov 24

Intracellular delivery of more than one protein with spatio-temporal control.
Lino MM, et al. Nanoscale. 2017 Nov 22.

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.
Teixeira J, et al. Toxicology. 2017 Nov 12

IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft.
Martins-Neves SR, et al. Cancer Lett. 2017 Nov 8

The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review.
Dionísio A, et al. J Stroke Cerebrovasc Dis. 2017 Oct 27

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties.
Santos SAO, et al. Mar Drugs. 2017 Nov 1

Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy.
Passadouro M, Faneca H. Methods Mol Biol. 2017 Oct 31

The Influence of Adipose Tissue on Brain Development, Cognition, and Risk of Neurodegenerative Disorders.
Letra L, Santana I. Adv Neurobiol. 2017

Combination of Poly[(2-dimethylamino)ethyl methacrylate] and Poly(β-amino ester) Results in a Strong and Synergistic Transfection Activity.
Santo D, et al. Biomacromolecules. 2017 Oct 9

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington´s disease.
Sjögren M, et al. Sci Rep. 2017 Oct 24

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
Spadari RC, et al. Cell Mol Neurobiol. 2017 Oct 24

Impact of developmental exposure to methylphenidate on rat brain´s immune privilege and behavior: control versus ADHD model.
Coelho-Santos V, et al. Brain Behav Immun. 2017 Oct 20

Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function.
Craveiro M, et al. Sci Signal. 2017 Oct 17

Adiponectin and sporadic Alzheimer´s disease: Clinical and molecular links.
Letra L, et al. Front Neuroendocrinol. 2017 Oct 13

A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial oxidative phosphorylation genes in gilthead sea bream (Sparus aurata).
Silva-Marrero JI, et al. BMC Genomics. 2017 Oct 11

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.
do Amaral RJFC, et al. Stem Cells Int. 2017

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Boia R, et al. Cell Death Dis. 2017 Oct 5

Steroidal oximes: useful compounds with antitumor activities.
Canário C, et al. Curr Med Chem. 2017 Oct 3

The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression.
Vecchione G, et al. Front Nutr. 2017 Sep 19

Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells.
Oliveira AI, et al. Cell Commun Signal. 2017 Oct 2

Impact of mesenchymal stem cells´ secretome on glioblastoma pathophysiology.
Vieira de Castro J, et al. J Transl Med. 2017 Oct 2

Computational studies of G protein-coupled receptor complexes: Structure and dynamics.
Sensoy O, et al. Methods Cell Biol. 2017

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.
Aday S, et al. Nat Commun. 2017 Sep 29

A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid´s proteome.
Trindade F, et al. Arch Biochem Biophys. 2017 Sep 23

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington´s disease.
Silva AC, et al. Biochim Biophys Acta. 2017 Sep 20

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors.
Cunha PP, et al. Hum Mol Genet. 2017 Aug 16

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Lemos V, et al. Hum Mol Genet. 2017 Jul 26

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.
Pereira SG, et al. Front. Microbiol. 2017 Sep 21

Multiple Sclerosis: Implications of Obesity in Neuroinflammation.
Novo AM, Batista S. Adv Neurobiol. 2017 Sep 21

The Influence of Adipose Tissue on Brain Development, Cognition, and Risk of Neurodegenerative Disorders.
Letra L, Santana I. Adv Neurobiol. 2017 Sep 21

Diabesity and Brain Energy Metabolism: The Case of Alzheimer´s Disease.
Cardoso S, et al. Adv Neurobiol. 2017 Sep 21

Hypothalamic Dysfunction in Obesity and Metabolic Disorders.
Carmo-Silva S, Cavadas C. Adv Neurobiol. 2017 Sep 21

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington´s disease.
Silva AC, et al. Biochim Biophys Acta. 2017 Sep 19

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes.
Gonçalves J, et al. Mol Autism. 2017 Sep 19

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.
Gregório AC, et al. Pathol Oncol Res. 2017 Sep 14

Matrisome Profiling During Intervertebral Disc Development And Ageing.
Caldeira J, et al. Sci Rep. 2017 Sep 14

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats.
Costa BPD, et al. Acta Cir Bras. 2017 Aug

Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study.
Rita Machado A, et al. Sci Rep. 2017 Sep 12

Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death.
Pereira LC, et al. J Toxicol Environ Health A. 2017 Sep 7

Distinct sensitivity to caffeine-induced insomnia related to age.
Frozi J, et al. J Psychopharmacol. 2017 Aug 1

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase.
Cereija TB, et al. Acta Crystallogr F Struct Biol Commun. 2017 Sep 1

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects.
Cardoso S, et al. Neurotox Res. 2017 Sep 5

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography.
Magalhães P, et al. J Anal Toxicol. 2017 Sep 1

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer´s Disease.
Amorim JA, et al. J Alzheimers Dis. 2017 Sep 1

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity.
Ferreira A, et al. Toxicology. 2017 Sep 1

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.
Ribeiro-Rodrigues TM, et al. Cardiovasc Res. 2017 Sep 1

Oral vaccination through Peyer´s Patches: update on particle uptake.
Soares E, Borges O. Curr Drug Deliv. 2017 Aug 25

The Parkinson´s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.
Morató X, et al. Sci Rep. 2017 Aug 25

Screening of pharmacokinetic properties of fifty dihydropyrimidin- (thi)one derivatives using a combo of in vitro and in silico assays.
Matias M, et al. Eur J Pharm Sci. 2017 Aug 2

Performance of HADDOCK and a simple contact-based protein-ligand binding affinity predictor in the D3R Grand Challenge 2.
Kurkcuoglu Z, et al. J Comput Aided Mol Des. 2017 Aug 22

Therapeutic strategies targeting oxidative stress to improve dyslipidemia and left ventricular hypertrophy.
Reis F. Rev Port Cardiol. 2017 Aug 18

SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots.
Moreira IS, et al. Sci Rep. 2017 Aug 14

Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis.
Costa BP, et al. J Surg Res. 2017 Aug

Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles.
Miranda A, et al. Int J Pharm. 2017 Aug 8

Id genes are essential for early heart formation.
Cunningham TJ, et al. Genes Dev. 2017 Aug 9

Alzheimer´s disease-related amyloid-β1-42 peptide induces the loss of human sperm function.
Tavares RS, et al. Cell Tissue Res. 2017 Aug 3

Functional and structural characterization of synthetic cardosin B-derived rennet.
Almeida CM, et al. Appl Microbiol Biotechnol. 2017 Aug 2

Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts.
Coelho AR, et al. Biochim Biophys Acta. 2017 Jul 28

Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches.
Miranda A, et al. Int J Pharm. 2017 Jul 27

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria.
Teixeira J, et al. Sci Rep. 2017 Jul 28

Photocatalytic ozonation using doped TiO2 catalysts for the removal of parabens in water.
Gomes JF, et al.Sci Total Environ. 2017 Jul 25

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study. Sousa J, et al. Res. 2017 Jul 26

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models.
Teixeira J, et al. J Med Chem. 2017 Aug 24

Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway.
Wojtala A, et al. Mitochondrion. 2017 Jul 21

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Gonçalves D, et al. Neuropharmacology. 2017 Jul 19

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Gonçalves D, et al. Neuropharmacology. 2017 Jul 19.

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
Santarino IB, et al. Sci Rep. 2017 Jul 19.

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software.
Perestrelo T, et al. Stem Cell Reports. 2017 Jul 3.

Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats.
Milton-Laskibar I, et al. Nutrients. 2017 Jul 11.

Glioblastoma entities express subtle differences in molecular composition and response to treatment.
Balça-Silva J, et al.  Oncol Rep. 2017 Jul 7.

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases.
font size="3">Rufino-Ramos D, et al. J Control Release. 2017 Jul 4.

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation.
Figueiredo SAC, et al. Eur J Med Chem. 2017 Jun 16.

  Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein.
Martins-Marques T, et al. Methods Mol Biol. 2017.

Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.
Santos T, et al. Acta Biomater. 2017 Jun 30.

Mitochondrial biology in cancer stem cells.
Semin Cancer Biol. 2017 Jun 30.

Chronic coffee consumption and respiratory disease: A systematic review
Alfaro TM, et al. Clin Respir J. 2017 Jul 3.

New multilocus genotypes of Giardia lamblia human isolates.
Faria CP, et al. Infect Genet Evol. 2017 Jun 29.

Dendritic cell-based immunotherapy: a basic review and recent advances
Constantino J, et al. Immunol Res. 2017 Jun 28.

The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells.
Balça-Silva J, et al. Transl Oncol. 2017 Jun 24.

S-nitrosylation of Ras mediates nitric oxide dependent post-injury neurogenesis in a seizure model
Santos AI, et al. Antioxid Redox Signal. 2017 Jun 24.

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF
Martins LF, et al. Sci Rep. 2017 Jun 23.

Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract
Gaspar MC, et al. Nat Prod Res. 2017 Jun 18.

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.
Gouveia PJ, et al. Biomaterials. 2017 Sep.

The Inclusion of Chitosan in Poly-ε-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure
Jesus S, et al. AAPS PharmSciTech. 2017 Jun 13.

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.
Ferreira A, et al. Food Chem Toxicol. 2017 Aug.

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.
Candeias E, et al. Mol Neurobiol. 2017 Jun 2.

Disconnection as a mechanism for social cognition impairment in multiple sclerosis.
Batista S, et al. Neurology. 2017 Jul 4.

Obstructive Sleep Apnea and Hallmarks of Aging
Gaspar LS, et al. Trends Mol Med. 2017 Jul 21.