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Publications 2018

Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains.
Carvalho FS, et al, Chem Biol Interact. 2018 Dec 25

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.
Canas PM, et al eNeuro. 2018 Dec 26.

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making.
Leffa DT, et al, Front Mol Neurosci. 2018 Dec 20

Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells.
Cabral Filho PE, et al, Biochim Biophys Acta Gen Subj. 2018 Dec

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles.
Lebre F,et al, Int J Pharm. 2018 Dec 1

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer´s drug candidates.
Piemontese L, et al, J Enzyme Inhib Med Chem. 2018 Dec

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.
Pólvora-Brandão D, et al, Hum Mol Genet. 2018 Dec 1

A translational view of cells´ secretome analysis - from untargeted proteomics to potential circulating biomarkers.
Anjo SI, et al, Biochimie. 2018 Dec

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.
Majorini MT, et al, Cell Death Differ. 2018 Dec

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Gomes AM., et al, Cell Reports 2018 Dec 4

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD in GPR37 deficient mice.
Morató X, et al, J Neurochem. 2018 Dec 22

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer´s and Parkinson disease pathology.
Esteves AR, et al, Biochim Biophys Acta Mol Basis Dis. 2018 Dec 17

Effects of a New Bioceramic Material on Human Apical Papilla Cells.
Sequeira DB, et al, J Funct Biomater. 2018 Dec 16

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.
Ferreira LL, et al, Food Chem Toxicol. 2018 Dec 14

Purinergic signalling and brain development.
Rodrigues RJ, et al, Semin Cell Dev Biol. 2018 Dec 4

Cysteine proteases secreted by the pinewood nematode, Bursaphelenchus xylophilus: In silico analysis.
Cardoso JMS, et al, Comput Biol Chem. 2018 Dec

Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens.
Tawk C, et al, EMBO J. 2018 Dec 3

Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate.
Perestrelo T, et al, Trends Cell Biol. 2018 Dec

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease.
Grattagliano I, et al, Biochem Pharmacol. 2018 Nov 30

MicroRNAs at the Host-Bacteria Interface: Host Defense or Bacterial Offense.
Aguilar C, et al, Trends Microbiol. 2018 Nov 23

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats.
Duarte JM, et al, Glia. 2018 Nov 21

Spectral features of nuclear DNA in human sperm assessed by Raman Microspectroscopy: Effects of UV-irradiation and hydration.
 Da Costa R, et al, PLoS One. 2018 Nov 20

The antifungal activity of extracts of Osmundea pinnatifida, an edible seaweed, indicates its usage as a safe environmental fungicide or as a food additive preventing post-harvest fungal food contamination.
Silva P, et al, Food Funct. 2018 Nov 20

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Bajzikova M, et al, Cell Metab. 2018 Nov 9

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles.
Ana R, et al, Int J Pharm. 2018 Nov 12

Orientation of nitro-group governs the fluorescence lifetime of nitrobenzoxadiazole (NBD)-labeled lipids in lipid bilayers.
Filipe HAL, et al, Phys Chem Chem Phys. 2018 Nov 12.

Diminished O-GlcNAcylation in Alzheimer´s disease is strongly correlated with mitochondrial anomalies.
Pinho TS, et al, Biochim Biophys Acta Mol Basis Dis. 2018 Nov 6.

Polymeric nanoengineered HBsAg DNA vaccine designed in combination with β-glucan.
Soares E, et al, Int J Biol Macromol. 2018 Nov 6

Draft genome sequence of Bacillus amyloliquefaciens subsp. plantarum strain Fito_F321, an endophyte microorganism from Vitis vinifera with biocontrol potential.
Pinto C, et al, Stand Genomic Sci. 2018 Nov 1

Cysteine proteases secreted by the pinewood nematode, Bursaphelenchus xylophilus: In silico analysis.
Cardoso JMS, et al, Comput Biol Chem. 2018 Oct 26

Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens.
Tawk C, et al, EMBO J. 2018 Nov 2

Process analytical technologies and injectable drug products: Is there a future?
Henriques J, et al, Int J Pharm. 2018 Oct 30

Miniature cheeses made with blends of chymosin and a vegetable rennet from flowers of Silybum marianum: Enzymatic characterization of the flower-coagulant peptidase.
Colombo ML, et al, Food Chem. 2018 Nov 15

Can antidiabetic drugs improve male reproductive (dys)function associated with diabetes?
Amaral S, et al, Curr Med Chem. 2018 Nov 1

Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy.
Calmeiro J, et al, IntechOpen, 2018 Nov 5

Influence of Passage Number on the Impact of the Secretome of Adipose Tissue Stem Cells on Neural Survival, Neurodifferentiation and Axonal Growth.
Serra SC, et al., Biochimie. 2018 Oct 17.

Anandamide Effects in a Streptozotocin-Induced Alzheimer´s Disease-Like Sporadic Dementia in Rats.
Moreira-Silva D, et al., Front Neurosci. 2018 Sep 21

Diabesity and brain disturbances: A metabolic perspective.
Cardoso S, Moreira PI., Mol Aspects Med. 2018 Oct 15

Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer´s Disease Cerebrospinal Fluid Biomarkers.
de Matos MR, et al., J Alzheimers Dis. 2018 Oct 9

BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo.
Singer W, et al Front Mol Neurosci. 2018 Sep 27

Targeted Theranostic Nanoparticles for Brain Tumor Treatment.
Mendes M, et al, Pharmaceutics. 2018 Oct 9

Shedding light on microRNA function via microscopy-based screening.
Rodrigues Lopes I, et al., Methods. 2018 Oct 5.

Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains.
Carvalho FS, et al. Chem Biol Interact. 2018 Oct 4

Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions.
Morais CM, et al., Biochim Biophys Acta Biomembr. 2018 Oct 4

Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation.
Diot A, et al., Front Cell Dev Biol. 2018 Sep 19

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses.
Louros SR, et al., Front Mol Neurosci. 2018 Sep 13

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses.
Kellermayer B, et al., Neuron. 2018 Oct 10

Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies.
Balça-Silva J, et al., Semin Cancer Biol. 2018 Sep 25

Wanted: MicroRNAs to the aid of the diabetic foot
Dalgaard LT & Carvalho E
Trends in Cardiovascular Medicine 2018 Sep 6

Multi-target-directed ligands for Alzheimer´s disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Reis J, et al. Eur J Med Chem. 2018 Sep 1

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles.
Lebre F, et al Int J Pharm. 2018 Sep 19.

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson´s Disease.
Mendes-Pinheiro B, et al Stem Cells Transl Med. 2018 Sep 20.

Amyloid β Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics.
Ribeiro MF, et al Mol Neurobiol. 2018 Sep 18.

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models.
Marcelo A, et al Hum Mol Genet. 2018 Sep 13.

Response to: Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema.
Campos A, et al Graefes Arch Clin Exp Ophthalmol. 2018 Sep 6.

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer´s disease: a two-in-one drug.
Chand K, et al. Metallomics. 2018 Sep 5.

Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics.
Naranjo MG, et al. OMICS. 2018 Sep 11.

An overview of antiretroviral agents for treating HIV infection in paediatric population.
Melo R, et a. Curr Med Chem. 2018 Sep 4.

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer´s Disease-Associated Amyloid-β and Tau Pathologies.
Guedes JR, et al. Front Neurol. 2018 Aug 14

Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast.
Araújo ARD, et al. PLoS One. 2018 Aug 27

Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics.
Ferreira AF, et al. J Phys Chem B. 2018 Aug 24

P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes-Transcriptomic Study.
Oliveira SR, et al. Mol Neurobiol. 2018 Aug 13

Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors.
Dobrachinski F, et al. Mol Neurobiol. 2018 Aug 13

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.
Pólvora-Brandão D, et al. Hum Mol Genet. 2018 Aug 8

In vitro anti-Leishmania activity of T6 synthetic compound encapsulated in yeast-derived B-(1,3)-d-glucan particles.
Volpato H, et al. Int J Biol Macromol. 2018 Aug 7

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Oliveira Miranda C, et al. Mol Ther. 2018 Jul 12

Treadmill Exercise Attenuates L-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice.
Speck AE, et al. Mol Neurobiol. 2018 Aug 2

Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.
Rodrigues CFD, et al. Sci Rep. 2018 Aug 1

Computational Approaches in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapy.
Melo R, et al. Curr Top Med Chem. 2018 Jul 31

Cerebrospinal Fluid Total Prion Protein in the Spectrum of Prion Diseases.
Villar-Piqué A, et al. Mol Neurobiol. 2018 Jul 30

Bioequivalence of topical generic products. Part 1: Where are we now?
Miranda M, et al. Eur J Pharm Sci. 2018 Jul 24

Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema.
Campos A, et al. Graefes Arch Clin Exp Ophthalmol. 2018 Jul 23

Author Correction: Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation.
Lima AF, et al. Sci Rep. 2018 Jul 23

Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events.
Carvalho C, Moreira PI. Front Physiol. 2018 Jul 3

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice.
Aguiar AS Jr, et al. Sci Rep. 2018 Jul 16

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.
Morató X, et al. Hum Mol Genet. 2018 Jul 16

Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery.
Delgado-Silva J, et al. Hypertens Res. 2018 Jul 13

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies.
Baptista FI, et al. Mol Neurobiol. 2018 Jul 12

Bioequivalence of topical generic products. Part 2. Paving the way to a tailored regulatory system.
Miranda M, et al. Eur J Pharm Sci. 2018 Sep 15

Total and regional bone mineral and tissue composition in female adolescent athletes: comparison between volleyball players and swimmers.
Valente-Dos-Santos J, et al. BMC Pediatr. 2018 Jul 3

Long-Term Neurobehavioral Consequences of a Single Ketamine Neonatal Exposure in Rats: Effects on Cellular Viability and Glutamate Transport in Frontal Cortex and Hippocampus.
Sampaio TB, et al. Neurotox Res. 2018 Jul 2

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy.
Fernandes C, et al. Bioconjug Chem. 2018 Jul 18

Evidence for distinct levels of neural adaptation to both coherent and incoherently moving visual surfaces in visual area hMT.
Sousa T, et al. Neuroimage. 2018 Oct 1

Molecular characterization of carbapenemases of clinical Acinetobacter baumannii-calcoaceticuscomplex isolates from a University Hospital in Tunisia.
Cheikh HB, et al.3 Biotech. 2018 Jul

Machado-Joseph disease / Spinocerebellar ataxia type 3:lessons from disease pathogenesis and clues into therapy.
Matos C, et al. J Neurochem. 2018 Jun 30

A practical framework for implementing Quality by Design to the development of topical drug products: Nanosystem-based dosage forms.
Simões A, et al. Int J Pharm. 2018 Jun 25

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira M, et al. Mol Psychiatry. 2018 Jun 27

GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling.
Matias D, et al. Mol Neurobiol. 2018 Jun 14

Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets.
Silva JCP, et al. J Proteome Res. 2018 Jul 2

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity.
Pereira SP, et al. Toxicol Sci. 2018 Jul 1

Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles.
Silva J, et al. AAPS PharmSciTech. 2018 Jul

Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations-Translocation of Cholesterol across Lipid Bilayers.
Filipe HAL, et al. J Chem Theory Comput. 2018 Jul 10

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer´s disease.
Silva AC, et al. Neurobiol Dis. 2018 Sep

Targeted alpha therapy using Radium-223: From physics to biological effects.
Marques IA, et al. Cancer Treat Rev. 2018 Jul

A Tutorial for Developing a Topical Cream Formulation Based on the Quality by Design Approach.
Simões A, et al. J Pharm Sci. 2018 Jun 20

Neurotensin, substance P, and insulin enhance cell migration.
Mouritzen MV, et al. J Pept Sci. 2018 Jun 25

A tutorial for developing a topical cream formulation based on the Quality by Design approach.
Simões A, et al. J Pharm Sci. 2018 Jun 20

Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity.
Balça-Silva J, et al. Exp Cell Res. 2018 Jun 11

A nanoformulation for the preferential accumulation in adult neurogenic niches.
Praça C, et al. J Control Release. 2018 Jun 15

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington´s Disease.
Duarte AI, et al. Sci Rep. 2018 Jun 12

Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles.
Silva J, et al. AAPS PharmSciTech. 2018 Jun 4

Targeted alpha therapy using Radium-223: From physics to biological effects.
Marques IA, et al. Cancer Treat Rev. 2018 May 25

Modulation of Cellular Respiration by Endogenously Produced Nitric Oxide in Rat Hippocampal Slices.
Ledo A, et al. Methods Mol Biol. 2018

Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells.
Silva AM and Oliveira PJ. Methods Mol Biol. 2018

O-GlcNAcylation and neuronal energy status: Implications for Alzheimer´s disease.
Pinho TS, et al. Ageing Res Rev. 2018 May 19

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.
Costa S, et al. Exp Parasitol. 2018 Jul

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices.
Dias C, et al. Anal Biochem. 2018 Jun 15

Repurposing drugs for glioblastoma: From bench to bedside.
Basso J, et al. Cancer Lett. 2018 Aug 1

Cardoon-based rennets for cheese production.
Almeida CM and Simões I. Appl Microbiol Biotechnol. 2018 Jun

Is the chlorophyll derivative Zn(II)e6Me a good photosensitizer to be used in root canal disinfection?
Diogo P, et al. Photodiagnosis Photodyn Ther. 2018 Jun

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.
Cunha-Oliveira T, et al. Toxicol Appl Pharmacol. 2018 Jun 1

Preliminary Outcomes Report for CO2 Laser Assisted Electric-Acoustic Cochlear Implantation.
Stevens SM, et al. Otol Neurotol. 2018 Jun

Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Caetano-Oliveira R, et al. Pathophysiology. 2018 Jun

Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes.
Burgeiro A, et al. Biochim Biophys Acta. 2018 Jun

The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation.
Gonçalves A, et al. Biomed Pharmacother. 2018 Jun

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells.
Encarnação JC, et al. J Nutr Biochem. 2018 Jun

Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification.
Fernandes AR, et al. Colloids Surf B Biointerfaces. 2018 Jun 1

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma.
Mendes M, et al. Eur J Pharm Sci. 2018 May 30

O-GlcNAcylation and neuronal energy status: implications for Alzheimer´s disease.
Pinho TS, et al. Ageing Res Rev. 2018 May 19

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.
Costa S, et al. Exp Parasitol. 2018 May 17

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices.
Dias C, et al. Anal Biochem. 2018 May 17

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.
Romano S, et al. Sci Rep. 2018 May 10

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation.
Lima AF, et al. Sci Rep. 2018 May 8

Repurposing drugs for glioblastoma: From bench to bedside.
Basso J, et al. Cancer Lett. 2018 May 3

Meeting the needs of breast cancer: A nucleolin´s perspective.
Gregório AC, Lacerda M, Figueiredo P, Simões S, Dias S, Moreira JN.Crit Rev Oncol Hematol. 2018 May

Cardoon-based rennets for cheese production.
Almeida CM & Simões I. Appl Microbiol Biotechnol. 2018 Apr 26

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.
Majorini MT, et al. Cell Death Differ. 2018 Apr 19

A whole brain longitudinal study in the YAC128 mouse model of Huntington´s disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.
Petrella LI, et al. Hum Mol Genet. 2018 Apr 16

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.
Cunha-Oliveira T, et al. Toxicol Appl Pharmacol. 2018 Apr 11

Author Correction: Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream.
Rito J, et al. Sci Rep. 2018 Apr 13

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.
Fernandes C, et al. Bioconjug Chem. 2018 Apr 19

Mitochondrial Biology and Experimental Therapeutics
Oliveira, Paulo J. Springer. 2018 April

Understanding metabolic diseases.
Carvalho, Eugénia. Pan Europeam Network. 2018 April

Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers.
Teodoro JS, et al. Eur J Clin Invest. 2018 Mar 30

Potential benefits of a sulfated resveratrol derivative for topical application.
Correia-da-Silva M, et al. J Mol Endocrinol. 2018 Mar 27

Efficacy Analysis of Capsaicin 8% Patch in Neuropathic Peripheral Pain Treatment.
Tenreiro Pinto J, et al. Pharmacology. 2018 Mar 27.

Efficacy Analysis of Capsaicin 8% Patch in Neuropathic Peripheral Pain Treatment.
Tenreiro Pinto J, et al. Pharmacology. 2018 Mar 27

Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex.
Real JI, et al. Eur J Neurosci. 2018 Mar 23

Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells.
Bellazzo A, et al. Cell Death Differ. 2018 Mar 22

Sweet Mitochondria: A Shortcut to Alzheimer´s Disease.
Moreira PI. J Alzheimers Dis. 2018

Mitochondrial Biology and Experimental Therapeutics
Oliveira, Paulo J. (editor). Springer. 2018 Mar 21

MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.
Andriani F, et al. J Hematol Oncol. 2018 Mar 20

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells.
Abreu PL, et al. Biometals. 2018 Mar 16

Data.
Ramalho-Santos J. Nature. 2018 Mar 15

CYP2D6 Pharmacogenetics Testing and Post-Cesarean Section Pain Scores-a Preliminary Study.
Ribeiro C, et al. Pain Med. 2018 Mar 12

Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test.
Matias M, et al. J Pharm Pharm Sci. 2018

Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification.
Fernandes AR, et al. Colloids Surf B Biointerfaces. 2018 Mar 5

In silico studies targeting G-protein coupled receptors for drug research against Parkinson´s disease.
Lemos A, et al. Curr Neuropharmacol. 2018 Mar 8

Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain.
Machado-Pereira M, et al. Neurosci Lett. 2018 Mar 5

MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo.
Saraiva C, et al. PLoS One. 2018 Mar 1

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer´s disease.
Hiremathad A, et al. Eur J Med Chem. 2018 Mar 25

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma.
Mendes M, et al. Eur J Pharm Sci. 2018 Feb 24

Brain insulin signalling, glucose metabolism and females´ reproductive aging: A dangerous triad in Alzheimer´s disease.
Duarte AI, et al. Neuropharmacology. 2018 Feb 19

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer´s disease.
Hiremathad A, et al. Eur J Med Chem. 2018

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP, et al. Cell Death Dis. 2018 Feb 20

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants.
Teixeira J, et al. Int J Biochem Cell Biol. 2018 Feb 14

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
Bicker J, et al. Eur J Pharm Sci. 2018 Feb 8

Stem Cell-Based Therapies for Polyglutamine Diseases.
Mendonça LS, et al. Adv Exp Med Biol. 2018

Gene Therapies for Polyglutamine Diseases.
Matos CA, et al. Adv Exp Med Biol. 2018

Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.
Nóbrega C, et al. Adv Exp Med Biol. 2018

Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease.
Carvalho AL, et al. Adv Exp Med Biol. 2018

Clinical Features of Machado-Joseph Disease.
Mendonça N, et al. Adv Exp Med Biol. 2018

Mitochondrial Dysfunction in Huntington´s Disease.
Carmo C, et al. Adv Exp Med Biol. 2018

An easy-to-use liquid chromatography method with fluorescence detection for the simultaneous determination of five neuroactive amino acids in different regions of rat brain.
Fonseca BM, et al. J Pharmacol Toxicol Methods. 2018 Feb 6

Elevated Pressure Changes the Purinergic System of Microglial Cells.
Rodrigues-Neves AC, et al. Front Pharmacol. 2018 Jan 24

Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?
Silva AF, et al. PLoS One. 2018 Feb 7

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.
Marques-Aleixo I, et al. Biochim Biophys Acta. 2018 Feb 12

Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant.
Bacalhau M, et al. Neuromuscul Disord. 2017 Nov 23.

Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases.
Zerr I, et al. Alzheimers Dement. 2018 Feb 3

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Ferreira A, et al. Food Res Int. 2018 Jan

TRAP1 regulates autophagy in lung cancer cells.
Barbosa IA, et al. Eur J Clin Invest. 2018 Jan 31

Raineya orbicola gen. nov., sp. nov. a slightly thermophilic bacterium of the phylum Bacteroidetes and the description of Raineyaceae fam. nov.
Albuquerque A. et al. IJSEM. Epub 2018 Jan 10

IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft.
Martins-Neves SR et al. Cancer Lett. 2018 Feb 1

 Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats.
Cardoso-Cruz H et al. Eur J Pain. 2018 Jan 26

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study.
Ribeiro M, Castelhano J et al. J Magn Reson Imaging. 2018 Jan 26

Carbon-1 versus Carbon-3 Linkage of d-Galactose to Porphyrins: Synthesis, Uptake, and Photodynamic Efficiency.
Pereira PMR et al. Bioconjug Chem. 2018 Jan 26

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK.
Panisello-Roselló A et al. Int J Mol Sci. 2018 Jan 24

Co-Transplantation of Adipose tissue-derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair.
Gomes ED et al. Stem Cells. 2018 Jan 20

Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion.
Martins RM et al. Int J Mol Sci. 2018 Jan 19

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.
Teixeira J et al. Toxicology. 2018 Jan 15

 Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream.
Rito J et al. Sci Rep. 2018 Jan 11

Stem cells as vehicles and targets of nanoparticles.
Pinho S et al. Drug Discov Today. 2018 Jan 11

 Uridine-5´-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells.
Palomo-Guerrero M et al. Neuroscience. 2018 Jan 11

 Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.
Sargento-Freitas J et al. Neurology. 2018 Jan 9

 Light-triggerable formulations for the intracellular controlled release of biomolecules.
Lino MM and Ferreira L. Drug Discov Today. 2018 Jan 8

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex.
Kerkhofs A et al. Front Pharmacol. 2018 Jan 4

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer.
Zupan?i? E et al. Nanomedicine. 2018 Jan 3

The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review.
Dionísio A et al. J Stroke Cerebrovasc Dis. 2018 Jan

Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy.
Passadouro M and Faneca H. Methods Mol Biol. 2018

 
   
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