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Pulications 2019

Understanding and Modulating Immunity With Cell Reprogramming.
Pires CF, et al, Front Immunol. 2019 Dec

Doxorubicin persistently rewires cardiac circadian homeostasis in mice.
Ferreira LL, et al, Arch Toxicol. 2019 Nov

Comparative genomics reveals a novel genetic organization of the sad cluster in the sulfonamide-degrader ´Candidatus Leucobacter sulfamidivorax´ strain GP.
Reis AC, et al, BMC Genomics. 2019 Nov

Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer´s disease.
Leitão MJ, et al, Alzheimers Res Ther. 2019 Nov

Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.
Aires ID, et al, Sci Rep. 2019 Nov

Porous poly(ε-caprolactone) implants: A novel strategy for efficient intraocular drug delivery.
Boia R, et al, Control Release. 2019 Dec

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer´s Disease.
Fancellu G, et al, J Enzyme Inhib Med Chem. 2020 Dec

A cross-sectional analysis of patient characteristics, health conditions and patient experience at a Portuguese medical acupuncture teaching appointment.
Marto CM, et al, Complement Ther Med. 2019 Dec

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues.
Chavarria D, et al, Molecules. 2019 Dec

FORSCells: 40-days fixed prepared reagent for detection of anti-Forssman in humans.
Ferreira S, et al, J Immunol Methods. 2019 Dec

Thrombophilic risk factors for retinal vein occlusion.
Vieira MJ, et al, Sci Rep. 2019 Dec

Sperm selection in assisted reproduction: A review of established methods and cutting-edge possibilities.
Marzano G, et al, Biotechnol Adv. 2019 Dec

An overview of glutaminyl cyclase inhibitors for Alzheimer´s disease.
Coimbra JR, et al, Future Med Chem. 2019 Dec

The Eighth ECS Workshop on "Calcium Signaling in Aging and Neurodegenerative Diseases".
Parys JB, et al, Int J Mol Sci. 2019 Dec

Insights on the Formulation of Recombinant Proteins.
Ribeiro R, et al, Adv Biochem Eng Biotechnol. 2019 Dec

Comparative Proteomic Analysis of Nodulated and Non-Nodulated Casuarina glauca Sieb. ex Spreng. Grown under Salinity Conditions Using Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS).
Graça I, et al, Int J Mol Sci. 2019 Dec

Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model.
Scariot DB, et al, Sci Rep. 2019 Dec

Cell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals.
Rodrigues ET, et al, Environ Sci Pollut Res Int. 2019 Dec

An overview of data-driven HADDOCK strategies in CAPRI rounds 38-45.
Koukos PI, et al, Proteins. 2019 Dec

Modified glutamatergic postsynapse in neurodegenerative disorders.
José Moraes B, et al, Neuroscience. 2019 Dec

Current challenges and emerging opportunities of CAR-T cell therapies.
Abreu T, et al, J Control Release. 2019 Dec

Proteomic Analyses Reveal New Insights on the Antimicrobial Mechanisms of Chitosan Biopolymers and Their Nanosized Particles against Escherichia coli.
Gomes LP,  et al, Int J Mol Sci. 2019 Dec

Immune Responses after Vascular Photodynamic Therapy with Redaporfin.
Lobo ACS, et al, J Clin Med. 2019 Dec

Gd- and Eu-Loaded Iron Oxide@Silica Core-Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging.
Pinho SLC, et al, Inorg Chem. 2019 Dec

Microglial Cell Dysfunction in CRB1-Associated Retinopathies.
Alves CH, et al, Adv Exp Med Biol. 2019

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.
Mold JE, et al, PLoS Biol. 2019 Oct

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.
Guedes RA, et al, Int J Mol Sci. 2019 Oct

Enzymatic Polymerization of PCL-PEG Co-polymers for Biomedical Applications.
Figueiredo P, et al, Front Mol Biosci. 2019 Oct

Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far.
Jesus S, et al, Front Bioeng Biotechnol. 2019 Oct

Highly Efficient Singlet Oxygen Generators Based on Ruthenium Phthalocyanines: Synthesis, Characterization and in vitro Evaluation for Photodynamic Therapy.
Ferreira JT,  et al, Chemistry. 2019 Oct

Lower CSF Amyloid-Beta1-42 Predicts a Higher Mortality Rate in Frontotemporal Dementia.
Vieira D, et al, Diagnostics (Basel). 2019 Oct

NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors.
Almeida JS, et al, Front Immunol. 2019 Oct

Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies.
Nascimento BFO,  et al, ACS Omega. 2019 Oct

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism.
Almeida N, et al, Redox Biol. 2019 Oct

A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.
Blersch J, et al, Angew Chem Int Ed Engl. 2019 Nov

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders.
Silva AC, et al, Brain. 2019 Nov

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid.
Chavarria D, et al, Org Biomol Chem. 2019 Nov

Bone Marrow Mesenchymal Stem Cells´ Secretome Exerts Neuroprotective Effects in a Parkinson´s Disease Rat Model.
Mendes-Pinheiro B, et al, Front Bioeng Biotechnol. 2019 Nov

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens.
Oliveira AS, et al, Environ Geochem Health. 2019 Nov

Dynamical Rearrangement of Human Epidermal Growth Factor Receptor 2 upon Antibody Binding: Effects on the Dimerization.
Magalhães PR,  et al, Biomolecules. 2019 Nov

Evaluation of Human Cerebrospinal Fluid Malate Dehydrogenase 1 as a Marker in Genetic Prion Disease Patients.
Zerr I, et al, Biomolecules. 2019 Nov

Fertility preservation with successful pregnancy outcome in a patient with transplanted heart and non-Hodgkin´s lymphoma - a case report.
Pais AS, et al, BMC Pregnancy Childbirth. 2019 Nov

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors.
Silvério-Alves R, et al, J Vis Exp. 2019 Nov

Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area.
Cabral Pinto MMS, et al, Int J Environ Res Public Health. 2019 Nov

miR-378a: a new emerging microRNA in metabolism.
Machado IF,  et al, Cell Mol Life Sci. 2019 Nov

Mitochondrial remodeling in human skin fibroblasts from sporadic PD male patients uncovers metabolic and mitochondrial bioenergetics defects.
Deus CM, et al, Biochim Biophys Acta Mol Basis Dis. 2019 Nov

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer´s disease: a longitudinal multimodal in vivo study.
Chiquita S,  et al, Alzheimers Res Ther. 2019 Nov

Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer´s disease.
Rosas I, et al, Neurobiol Aging. 2019 Nov

Self-Modulation of Premotor Cortex Interhemispheric Connectivity in a Real-Time Functional Magnetic Resonance Imaging Neurofeedback Study Using an Adaptive Approach
Pereira J, et al, Brain Connect. 2019 Nov

Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation.
Henriques D, et al, Front Neurosci. 2019 Nov

The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington´s disease individuals.
Júlio F, et al, Orphanet J Rare Dis. 2019 Nov

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington´s disease mice.
Pinho BR, et al, Free Radic Biol Med. 2019 Nov

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
Gomes P, et al, Ageing Res Rev. 2019 Nov

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Moore KM, et al, Lancet Neurol. 2019 Dec

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases.
Gomes P, et al, Trends Pharmacol Sci. 2019 Dec

Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection.
Aguilar C, et al, Nat Microbiol. 2019 Dec

Nanotechnological breakthroughs in the development of topical phytocompounds-based formulations.
Santos AC, et al, Int J Pharm. 2019 Dec

Pharmacotherapeutic strategies for methamphetamine use disorder: mind the subgroups.
Soares E, et al, Expert Opin Pharmacother. 2019 Dec

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.
van der Ende EL, et al, Lancet Neurol. 2019 Dec

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis
Belew GD, et al, J Lipid Res. 2019 Dec

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity.
Pinto P, et al, Eur J Med Chem. 2019 Oct 

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges.
Vitorino C, et al, Drug Discov Today. 2019 Sep

Hybrid Nanostructured Films for Topical Administration of Simvastatin as Coadjuvant Treatment of Melanoma.
Barone A,  et al, J Pharm Sci. 2019 Oct

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice.
Silva J, et al, Biomed Chromatogr. 2019 Oct

Developing Cream Formulations: Renewed Interest in an Old Problem.
Simões A, et al, J Pharm Sci. 2019 Oct

On demand for new process analytical technologies applied to injectable drug products.
Henriques J,  et al, Eur J Pharm Sci. 2019 Sep 

Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil.
Miranda M,  et al, Mater Sci Eng C Mater Biol Appl. 2019 Oct

Targeted siRNA Delivery Using Lipid Nanoparticles.
Jorge A, et al, IMethods Mol Biol. 2020

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study.
Van Maurik IS, et al, Lancet Neurol. 2019 Nov

aQbD as a platform for IVRT method development-A regulatory oriented approach.
Miranda M, et al, Int J Pharm. 2019 Sep 

Quality and Equivalence of Topical Products: A Critical Appraisal.
Miranda M,  et al, Eur J Pharm Sci. 2019 Oct 

Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma.
Morais CM,  et al, Hum Mol Genet. 2019 Sep 

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.
Gomes AS, et al, ABiochim Biophys Acta Gen Subj. 2019 Sep 

Correspondence reply referring to the correspondence of Schirmer et al. (2019) received by Environmental Pollution regarding the publication Rodrigues et al. (2019).
Pardal MA, et al, Environ Pollut. 2019 Nov

Hormones, Blood Products, and Therapeutic Enzymes.
Silva AC, et al, Adv Biochem Eng Biotechnol. 2019 Se

Metabolic Effects of Dietary Glycerol Supplementation in Muscle and Liver of European Seabass and Rainbow Trout by 1H NMR Metabolomics.
Palma M, et al, Metabolites. 2019 Sep 

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory.
Ribeiro M, et al, Sci Immunol. 2019 Oct 

ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to improve insulin secretion and diabetic glucose profile.
Crisóstomo J, et al, J Appl Biomater Funct Mater. 2019 Oct

Impact of direct oral anticoagulants off-label doses on clinical outcomes of atrial fibrillation patients: a systematic review.
Santos J, et al, Br J Clin Pharmacol. 2019 Oct

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.
Mold JE, et al, PLoS Biol. 2019 Oct 

Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.
Daniel MG, et al, FEBS Lett. 2019 Sep 

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics-A Critical Review.
Diogo P, et al, J Funct Biomater. 2019 Sep 

Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis.
Belew GD, et al, J Lipid Res. 2019 Oct 

Is Alzheimer´s disease an inflammasomopathy?
Pereira CF, et al, Ageing Res Rev. 2019 Sep 

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson´s Disease.
Valdinocci D, et al, Front Neurosci. 2019 Sep 

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress.
Ferreira LMR, et al, Int J Mol Sci. 2019 Oct 

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.
Valdeira ASC, et al, J Nat Prod. 2019 Aug 23

Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy.
Calmeiro J, et al, J Immunother Cancer. 2019 Sep 4

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.
Praça C,  et al, Stem Cell Reports. 2019 Sep 5.

Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma.
Morais CM, et al, Hum Mol Genet. 2019 Sep 13.

Research update for articles published in EJCI in 2017.
Arellano-Orden E, et al, Eur J Clin Invest. 2 Epub 2019 Sep 16.

A near infrared light-triggerable modular formulation for the delivery of small biomolecules.
Francisco V,  et al, J Nanobiotechnology. 2019 Sep 16

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.
Gomes AS,  et al, Biochim Biophys Acta Gen Subj. 2019 Sep 16

aQbD as a platform for IVRT method development-A regulatory oriented approach.
Miranda M, et al, Int J Pharm. 2019 Sep 16

The multi-factorial nature of clinical multidrug resistance in cancer.
Assaraf YG, et al, Drug Resist Updat. 2019 Sep 17

Correspondence reply referring to the correspondence of Schirmer et al. (2019) received by Environmental Pollution regarding the publication Rodrigues et al. (2019).
Pardal MA, et al, Environ Pollut. 2019 Nov

Cytogenetics and Cytogenomics Evaluation in Cancer.
Ribeiro IP,  et al, nt J Mol Sci. 2019 Sep 23

Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic co-culture.
Daniel MG,  et al, FEBS Lett. 2019 Sep 26.

Hormones, Blood Products, and Therapeutic Enzymes.
Silva AC, et al, Adv Biochem Eng Biotechnol. 2019 Sep 27

Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model.
Campos EJ, et al, Ann Anat. 2019 Sep 26

Metabolic Effects of Dietary Glycerol Supplementation in Muscle and Liver of European Seabass and Rainbow Trout by 1H NMR Metabolomics.
Palma M, et al, Metabolites. 2019 Sep 27

Is Alzheimer´s disease an inflammasomopathy?
Pereira CF, et al, Ageing Res Rev. 2019 Sep 29

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics-A Critical Review.
Diogo P, et al, J Funct Biomater. 2019 Sep 30

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.
Palmeira CM, et al, Free Radic Biol Med. 2019 Sep

Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer´s disease.
Tábuas-Pereira M, et al, Epilepsy Behav. 2019 Sep

Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis.
Belew GD, et al, J Lipid Res. 2019 Oct 1

Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy
Calmeiro João, et al Journal for ImmunoTherapy of Cancer volume 7, Article number: 238 (2019)

Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.
L, Jaffrey SR, et al, Cell Rep. 2019 Jul 23

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata.
Silva-Marrero JI, et al, Biomolecules. 2019 Jul 24

FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis.
Ferreira D, et all, Cell Mol Life Sci. 2019 Jul 25

Pre-analytical stability of novel cerebrospinal fluid biomarkers.
Willemse EAJ, et al, Clin Chim Acta. 2019 Oct; Epub 2019 Jul 23.

Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil.
Miranda M, et al, Epub 2019 May 30

Biological Functions of Connexin43 Beyond Intercellular Communication.
Martins-Marques T, et al, Trends Cell Biol. 2019 Jul 26

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration.
Henriques-Antunes H, et al, ACS Nano. 2019 Aug 27

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer´s disease depends on increased formation of ATP-derived extracellular adenosine.
Gonçalves FQ, et al, Neurobiol Dis. 2019 Aug 5

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
Mendes VM, et al, Molecules. 2019 Aug 7

The dipeptidyl peptidase 4 inhibitor sitagliptin improves oxidative stress and ameliorates glomerular lesions in a rat model of type 1 diabetes.
Marques C, et al, Life Sci. 2019 Aug 6

The chemistry toolbox of multitarget-directed ligands for Alzheimer´s disease.
Mesiti F, et al, Eur J Med Chem. 2019 Aug 1

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Gomes S, et al, Cancers (Basel). 2019 Aug 10

Language Predictors in Autism Spectrum Disorder: Insights from Neurodevelopmental Profile in a Longitudinal Perspective.
Mouga S, et al, J Abnorm Child Psychol. 2019 Aug 13

Shaping the Nrf2-ARE-related pathways in Alzheimer´s and Parkinson´s diseases.
Fão L, et al, Epub 2019 Aug 12. Review. PMID:31415806

Functional and Phenotypic Characterization of Tumor-Infiltrating Leukocyte Subsets and Their Contribution to the Pathogenesis of Hepatocellular Carcinoma and Cholangiocarcinoma.
Martín-Sierra C, et al, Transl Oncol. 2019 Aug 16

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease.
Fontes A, et al, Int J Mol Sci. 2019 Aug 16

SWATH Mass Spectrometry Applied to Cerebrospinal Fluid Differential Proteomics: Establishment of a Sample-Specific Method.
Anjo SI, et al, Methods Mol Biol. 2019

Untargeted Metabolomics Relative Quantification by SWATH Mass Spectrometry Applied to Cerebrospinal Fluid.
Mendes VM, et al, Methods Mol Biol. 2019

Targeted siRNA Delivery Using Lipid Nanoparticles.
Jorge A, et al, Methods Mol Biol. 2020

Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment.
Anjo SI, et al, Epub 2019 Jul 18.

Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: brain region and sex specificities.
Henriques CFS, et al, Eur J Neurosci. 2019 Aug 27

Poly(β-amino ester)-based gene delivery systems: From discovery to therapeutic applications.
Cordeiro RA, et al, J Control Release. 2019 Aug 24;

A Mitochondrial Approach to Cardiovascular Risk and Disease.
Veloso CD, et al, Curr Protein Pept Sci. 2019 Aug 30

Advances in biomarker detection: Alternative approaches for blood-based biomarker detection.
Rosado M, et al Adv Clin Chem. 2019

The Two Faces of Tumor-Associated Macrophages and Their Clinical Significance in Colorectal Cancer.
Pinto ML, et al, Front Immunol. 2019 Aug 20

Draft Genome Sequence of Brevundimonas sp. Strain T2.26MG-97, Isolated from a Rock Core Sample from 492.6 Meters Deep on the Subsurface of the Iberian Pyrite Belt.
Rodríguez-Robles E, et al, Microbiol Resour Announc. 2019 Aug 8

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives.
Alho DPS, et al, Molecules. 2019 Aug 14

A photodynamic antibacterial spray-coating based on the host-guest immobilization of the photosensitizer methylene blue.
Yao TT, et al, J Mater Chem B. 2019 Aug 21

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue.
Silva JCP, et al, etab Eng. 2019 Aug 29

The Brain Buskers Project: taking science to the streets
Barros-Viegas Ana Teresa , et all, The Biochemist, 2019 August

Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells.
Nunes C, et al, Chem Biol Interact. 2019 Jun 15

Draft Genome Sequence of Brevundimonas sp. Strain T2.26MG-97, Isolated from a Rock Core Sample from 492.6 Meters Deep on the Subsurface of the Iberian Pyrite Belt.
Rodríguez-Robles E, et all, Microbiol Resour Announc. 2019 Aug 8

Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.
Costa RO, et all, Cell Rep. 2019 Jul 23

Replacing Di(2-ethylhexyl) Terephthalate by Di(2-ethylhexyl) 2,5-Furandicarboxylate for PVC Plasticization: Synthesis, Materials Preparation and Characterization.
Matos M, et all, Materials (Basel). 2019 Jul 23

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.
Valdeira ASC, et al, J Nat Prod. 2019 Jul 25

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata.
Silva-Marrero JI, et all, Biomolecules. 2019 Jul 24

FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis.
Ferreira D, et all, Cell Mol Life Sci. 2019 Jul 25

Pre-analytical stability of novel cerebrospinal fluid biomarkers.
Willemse EAJ, et all, Clin Chim Acta. 2019 Jul 23.

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.
Palmeira CM, et all, Free Radic Biol Med. 2019 Jul 24

Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer´s disease.
Tábuas-Pereira M, et all, Epilepsy Behav. 2019 Aug 2

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer´s disease depends on increased formation of ATP-derived extracellular adenosine.
Gonçalves FQ, et all, Neurobiol Dis. 2019 Aug 5

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
Mendes VM, et all, Molecules. 2019 Aug 7

The Brain Buskers Project: taking science to the streets
Barros-Viegas Ana Teresa , et all, The Biochemist, 2019 August

5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities.
Figueiredo J, et al, Eur J Pharm Sci. 2019 Jun 21

Chitosan/poly(γ-glutamic acid) nanoparticles incorporating IFN-γ for immune response modulation in the context of colorectal cancer.
Castro F, et al, Biomater Sci. 2019 Jun 24

Heartfelt exercise: Physical exercise gets the cardiovascular system into shape.
C Pereira F., Rev Port Cardiol. 2019 Jun 18

Retinal texture biomarkers may help to discriminate between Alzheimer´s, Parkinson´s, and healthy controls.
Nunes A, et al, PLoS One. 2019 Jun 21

Corrigendum to "oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening" [Redox Biology (2019) 101130].
Anjo SI, et al, Redox Biol. 2019 Jun 17

Chicken egg yolk antibody (IgY) as diagnostics and therapeutics in parasitic infections - A review.
Diraviyam T, et al, Int J Biol Macromol. 2019 Jun 17

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson´Ss Disease.
Carmo M, et al, Br J Pharmacol. 2019 Jun 20

Developing cream formulations: renewed interest in an old problem.
Simões A, et all, J Pharm Sci. 2019 Jun 16.

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice.
Silva J, et al, Biomed Chromatogr. 2019 Jun 18

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons.
Afonso P, et al, Sci Signal. 2019 Jun 18

Early manifestation of myocardial involvement in systemic sclerosis.
Marques-Alves P, et al, Rev Port Cardiol. 2019 Apr

Hybrid nanostructured films for topical administration of simvastatin as coadjuvant treatment of melanoma.
Barone A, et al, J Pharm Sci. 2019 Jun 12

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors.
Lopes JP, et al, Biochem Pharmacol. 2019 Jun 12

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.
Nóbrega C, et all, Acta Neuropathol. 2019 Jun 14

The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits.
Serrenho D, et al, Front Cell Neurosci. 2019 May 27

Early Interaction of Alternaria infectoria Conidia with Macrophages.
Almeida MC, et al, Mycopathologia. 2019 Jun 11

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges.
Vitorino C, et al, Drug Discov Today. 2019 Jun 7

Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw.
Paulo S, et al, Materials (Basel). 2019 Jun 6

Neural correlates of anticipatory cardiac deceleration and its association with the speed of perceptual decision-making, in young and older adults.
Ribeiro MJ, et al, Neuroimage. 2019 Jun 5

Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling.
Santos-Alves E, et al, Mitochondrion. 2019 Jun 3

Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides.
Rodrigues ET, et al, Environ Pollut. 2019 May 27

Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction.
Aguilar C, et al, Microbiol Spectr. 2019 May

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review.
Gouveia F, et al, Anal Chim Acta. 2019 Oct 17

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.
Nóbrega C, et al, Acta Neuropathol. 2019 Jun 14

Histamine modulates hippocampal inflammation and neurogenesis in adult mice.
Saraiva C, et al, Sci Rep. 2019 Jun 10

Education modulates brain maintenance in presymptomatic frontotemporal dementia.
Gazzina S, et al, J Neurol Neurosurg Psychiatry. 2019 Jun 10.

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
Mullins N, et al, Am J Psychiatry. 2019 Jun 5

Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells.
Nunes C, et al, Chem Biol Interact. 2019 Jun 14

Parvoviral infection with systemic impact and renal consequences.
Mira FS, et al, BMJ Case Rep. 2019 Jun 8

Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling.
Santos-Alves E, et al, Mitochondrion. 2019 Jun 3

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
Gerardo H, et al, Scientific Reports. 2019 jun 24

Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain.
Ledo A, et al, Adv Exp Med Biol. 2019

High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital.
Tiago I, et al, Microbiol Resour Announc. 2019 May 23

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism.
Mouro FM, et al, Neuropharmacology. 2019 May 16

Post-translational modifications in brain health and disease.
Correia SC, et al, Biochim Biophys Acta Mol Basis Dis. 2019 May 15

The importance of determining circadian parameters in pharmacological studies.
Gaspar L, et al, Br J Pharmacol. 2019 May 16

Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.
Manso JA, et al, MBio. 2019 May 14

Molecular and Cellular Characterization of SIRT1 Allosteric Activators.
Schultz MB, et al, Methods Mol Biol. 2019

MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy.
Cardoso AMS, et al, Hum Mol Genet. 2019 May 14

Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections.
Carbone C, et al, Pharmaceutics. 2019 May 13

Polyphenols as food bioactive compounds in the context of Autism Spectrum Disorders: A critical mini-review.
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Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer´s Disease.
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Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study.
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Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection.
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Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.
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Comparative proteomic analysis of saliva from dogs with and without obesity-related metabolic dysfuntion.
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The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis.
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A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods.
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Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system.
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Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.
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Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain.
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Editorial commentary: Wanted: MicroRNAs to the aid of the diabetic foot.
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microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation.
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Immune aging in diabetes and its implications in wound healing.
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Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation.
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Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders.
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Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment.
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A Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Trigger Differential Proteome Signatures in Macrophages.
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Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment.
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Hippocampal mossy fibers synapses in CA3 pyramidal cells are altered at an early stage in a mouse model of Alzheimer´s disease.
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Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles.
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Functional characterization of iPSC-derived arterial- and venous-like endothelial cells.
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Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2.
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A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss.
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MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons.
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Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice.
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MicroRNAs at the Host-Bacteria Interface: Host Defense or Bacterial Offense.
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Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation.
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Claspin: From replication stress and DNA damage responses to cancer therapy.
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Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia.
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Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.
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An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.
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A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin.
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RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3.
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Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant.
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New insights on synaptic dysfunction in neuropsychiatric disorders.
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New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer´s Disease.
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Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain.
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Atypical and nucellin-like aspartic proteases: emerging players in plant developmental processes and stress responses.
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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis.
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Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.
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Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease.
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Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
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Polymeric nanoengineered HBsAg DNA vaccine designed in combination with βglucan.
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Response to: Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema.
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Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of  Three Treadmill Running Protocols.
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The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer´s Disease.
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Unveiling the molecular crosstalk in a Human Induced Pluripotent Stem Cell Derived Cardiac Model.
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The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer´s Disease: Critical Aspects to Unravel.
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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis.
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Suicide Gene Therapy for Oral Squamous Cell Carcinoma.
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Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats.
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Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles.
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Preparation of gentamicin sulfate eluting fiber mats by emulsion and by suspension electrospinning.
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Process analytical technologies and injectable drug products: Is there a future?
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Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats
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Association between Adipokines and Biomarkers of Alzheimer´s Disease: A Cross-Sectional Study
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Shedding light on microRNA function via microscopy-based screening
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Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models.
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Correspondence.
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