Neurociências e Doença

Agasse F, Bernardino L, Kristiansen H, Christiansen SH, Ferreira R, Silva B, Grade S, Woldbye DP and Malva JO (2008) Neuropeptide Y Promotes Neurogenesis in Murine Subventricular Zone. Stem Cells 26: 1636-1645.

Agasse F, Bernardino L, Silva B, Ferreira R, Grade S and Malva JO (2008) Response to histamine allows the functional identification of neuronal progenitors, neurons, astrocytes and immature cells in subventricular zone cell cultures. Rejuvenation Res. 11:187-200.

Agostinho P, Lopes JP, Velez Z, Oliveira CR (2008) Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem. Int. 52, 1226-1233.

Almeida S, Sarmento-Ribeiro AB, Januário C, Rego AC, Oliveira CR (2008) Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntingtons disease patients. Biochem. Biophys. Res. Commun. 374, 599-603.

Álvaro AR, Martins J, Costa AC, Fernandes E, Carvalho F, Ambrósio AF, Cavadas C (2008) Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience 152:97-105.

Álvaro AR, Martins J, Araújo IM, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C (2008) Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide. J Neurochem 105:2501-2510.

Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P, Carvalho CM (2008) Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus. J. Neurochem. 105:666-676.

Arduíno D, Silva D, Cardoso SM, Chaves S, Oliveira CR, Santos MA (2008) Synthesis and investigation of new hydroxypyridinone based iron-chelators as potential anti-neurodegenerative drug candidates. Front. Biosci. 13,6763-6774.

Bernardino L, Agasse F, Silva B, Ferreira R, Grade S and Malva JO (2008) Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells 26: 2361-2371.

Bernardino L, Balosso S, Ravizza T, Marchi N, Ku G, Randle JC, Malva JO and Vezzani A (2008) Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X(7) receptor-mediated IL-1beta release. J. Neurochem. 106: 271-280.

Canas PM, Duarte JM, Rodrigues RJ, Köfalvi A, Cunha RA (2008) Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiol. Aging 25.

Cardoso S, Santos RX, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Moreira PI (2008) Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage. Free Radic. Biol. Med. 45, 1395-1402.

Carvalho AL, Caldeira MV, Santos SD, Duarte CB. (2008) Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br. J. Pharmacol. 153 Suppl 1:S310-24.

Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI (2008) Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med. Chem. 4:358-364.

Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA (2008) Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Exp. Neurol. 210:776-81.

Cunha-Oliveira T, Rego AC, Oliveira CR (2008) Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev. 58:192-208.

Cunha RA, Ferré S, Vaugeois JM, Chen JF (2008) Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr. Pharm. Des. 14:1512-24.

Domingues AF, Arduíno DM, Esteves ARF, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Mitochondria and Ubiquitin Proteasomal System interplay in Parkinsons disease. Free Radic. Biol. Med. 45:820-825.

Domingues AF, Esteves ARF, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells. Neurotox. Res. 13,31-88.

Donato R, Rodrigues RJ, Takahashi M, Tsai MC, Soto D, Miyagi K, VillafuertesRG, Cunha RA, Edwards FA. (2008) GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx. Cell Calcium. 44:521-32.

Duarte AI, Santos P, Oliveira CR, Santos MS, Rego AC (2008) Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression. Biochem Biophys Acta – Mol Cell Res 1783: 994-1002.

Esteves ARF, Arduíno DM, Swerdlow RH, Oliveira CR, Cardoso SM (2008) Oxidative Stress potentiates alpha-synuclein oligomerization in PD Cybrids. Antiox. Redox Signal.

Esteves ARF, Domingues AF, Ferreira IL, Januário C, Swerdlow RH, Oliveira CR and Cardoso SM (2008) Mitochondrial dysfunction occurs in parkinson’s disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion 8,219-228.

Ferreiro E, Costa R, Marques S, Cardoso SM, Oliveira CR, Pereira C (2008) Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP106-126. J. Neurochem. 104,766-776.

Ferreiro E, Oliveira CR, Pereira CM (2008) The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol. Dis. 30,331-342.

Figueiredo C, Pais TF, Gomes JR, Chatterjee S (2008) Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2. J. Neurochem. 107, 73-85.

Gil JM, Rego AC (2008) Mechanisms of neurodegeneration in Huntington’s disease. Eur. J. Neurosci. 27, 2803-2820.

Gomes AR, Ferreira JS, Paternain AV, Lerma J, Duarte CB, Carvalho AL (2008) Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors. Mol. Cell Neurosci. 37, 323–334.

Gonçalves J, Martins T, Ferreira R, Milhazes N, Borges F, Ribeiro CF, Malva JO, Macedo TR and Silva AP (2008) Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Ann. N. Y. Acad. Sci. 1139:103-111.

Leal E, Aveleira CA, Castilho AF, Baptista FI, Ambrósio AF (2008) Muller cells do not influence leukocyte adhesion to retinal endothelial cells. Ocul. Immunol. Inflamm. 16:173-179.

Matos M, Augusto E, Oliveira CR, Agostinho P (2008) Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and MAP Kinase cascades. Neuroscience 156,898-910.

Rebola N, Lujan R, Cunha RA, Mulle C (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57:121-34.

Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) ER stress is involved in Aβ-induced GSK-3β activation and tau phosphorylation. J. Neurosci. Res. 86,2091-2099.

Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) Neurotoxic effect of oligomeric and fibrillar species of A1-42 peptide. Involvement of ER calcium release in oligomers-induced cell death. Neuroscience 155,725-737.

Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR (2008) Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic. Biol. Med. 44,2051-2057.

Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA (2008) Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiol. Aging 29:1597-601

Saavedra A, Baltazar G, Duarte EP (2008) Driving GDNF expression: The green and the red traffic lights. Prog. Neurobiol. 86, 186-215.

Santiago AR, Carvalho, CM, Carvalho AP, Ambrósio, AF (2008). Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons. Neurochem. Res. 33: 1501-1508.

Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO and Ambrósio AF (2008) Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res. 1198:153-159.

Santos AR, Duarte CB (2008) Validation of internal control genes for expression studies: effects of the neurotrophin BDNF on hippocampal neurons. J. Neurosci. Res. 86, 3684-3692.

Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF (2008) A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J. Neurosci. 28:2970-5.

Silva AM, Rodrigues RJ, Tomé AR, Cunha RA, Misler S, Rosário LM, Santos RM (2008) Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells. Pancreas 36:279-83.

Silva BA, Malva JO and Dias ACP (2008) St. John’s worth (H. perforatum) extracts and isolated compounds are effective antioxidants in several in vitro models of oxidative stress. Food Chem. 110: 611-619.

Silva B, Oliveira PJ, Dias ACP and Malva JO (2008) Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults. Neurotoxicity Res. 13: 265-279.

Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. U.S.A. 105,19318-19323.

Xapelli S, Bernardino L, Ferreira R, Grade S, Silva AP, Salgado JR, Cavadas C, Grouzmann E, Poulsen FR, Jakobsen B, Oliveira CR, Zimmer J and Malva JO (2008) Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. Eur. J. Neurosci. 27: 2089-2102.

Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF (2008) Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Ann. Neurol. 63:338-46.