Toxicologia Celular e Molecular

Almeida L, Nunes T, Falcão AC, Minciu I, Magureanu SA, Butoianu N, Soares-da-Silva P (2008) Pharmacokinetics, Efficacy, and Tolerability of Eslicarbzepine Acetate in Children and Adolescents. J. Clin. Pharmacol. 48: 966-977.

Almeida L, Falcão AC, Coelho R, Albino-Teixeira A, Soares-da-Silva P (2008) The role of socio-economic conditions and personality characteristics on the willingness to volunteer for phase I studies. Pharm. Med. 22(6): 367-374.

Almeida L, Falcão AC, Vaz-da-Silva M, Coelho R, Albino-Teixeira A, Soares-da-Silva P (2008) Personality characteristics of volunteers to Phase 1 studies and likelihood of reporting adverse events. Int. J. Clin. Pharmacol. Ther. 46(7): 340-348.

Almeida L, Falcão AC, Vaz-da-Silva M, Nunes T, Santos AT, Rocha JF, Neto C, Macedo T, Fontes-Ribeiro C, Soares-da-Silva P (2008) Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Eur. J. Clin. Pharmacol. 64: 961-966.

Almeida L, Minciu I, Nunes T, Butoianu N, Falcão AC, Magureanu SA, Soares-da-Silva P (2008) Pharmacokinetics of eslicarbazepine acetate in children and adolescents with epilepsy. J. Clin. Pharmacol. 48: 966-977.

Alves E, Summavielle T, Alves CJ, Custódio JBA, Fernandes E, Bastos ML, Tavares MA, Carvalho F (2008) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict. Biol. 14:185-93.

Alves G, Figueiredo I, Falcão AC, Castel-Branco M, Caramona MM, Soares-da-Silva P (2008) Stereoselective disposition of S- and R-Licarbazepine in the mouse. Chirality 20(6): 796-804.

Alves GL, Fortuna A, Falcão AC (2008) High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review. Trends Chromatography 4: 1-10.

Alves GL, Figueiredo IV, Castel-Branco MM, Lourenço N, Falcão AC, Caramona MM, Soares-da-Silva P (2008) Disposition of Eslicarbazepine Acetate in the Mouse after Oral Administration. Fund. Clin. Pharmacol. 22(5): 529-36.

Alves Ema, Summavielle Teresa, Alves CJ, Custódio JBA, Fernandes E, Bastos ML, Tavares MA, Carvalho F (2008) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict. Biol. 14:185-93.

Barbosa RM, Marques CF, Santos RM, Pomerleau F, Huettl P, Gerhardt GA and Laranjinha J (2008) In vivo real time measurement of endogenous nitric oxide in anesthetized rat brain. Methods in Enzymology 441, 351-367.

Bem AF, Farina M, Portella RD, Nogueira CW, Dinis TC, Laranjinha JA, Almeida LM, Rocha JB (2008) Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis 201, 92-100.

Brito PM, Devillard R, Nègre-Savayre A, Almeida LM, Dinis TCP, Salvayre R and Augé N (2008) Resveratrol inhibits the mTOR mitogenic signalling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis. doi:10.1016/J.Atherosclerosis.2008.11.011.

Brito PM, Simões NF, Almeida LM and Dinis TCP (2008) Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Apoptosis 13 1043-1053.

Cardoso S, Santos R X, Carvalho C, Correia S, Pereira GC, Pereira SS, Oliveira PJ, Santos MS, Proença T, Seiça R, Oliveira CR, Moreira P (2008) Doxorubicin Increases the Susceptibility of Brain Mitochondria to the Calcium-induced Permeability Transition and Oxidative Damage. Free Rad. Biol. Med. 45(10):1395-402.

Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI (2008). Metformin promotes isolated rat liver mitochondria impairment. Mol. Cell Biochem. 308(1-2):75-83.

Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI (2008) Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem. 4:358-64.

Fernandes MAS, Marques RJF, Vicente JAF, Santos MS, Monteiro P, Moreno AJM, Custódio JBA (2008) Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria. Mol. Cell. Biochem. 309, 77-85.

Fernandes MAS, Pereira SPS, Jurado AS, Custódio JBA, Santos MS, Moreno AJM, Duburs G and Vicente JAF (2008) Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance of the length of the alkoxyl chain in positions 3 and 5 of the DHP ring. Chemico-Biological Interactions 173: 195-204.

Fontes-Ribeiro C, Macedo T, Nunes T, Neto C, Vasconcelos T, Cerdeira R, Lima R, Rocha JF, Falcão AC, Almeida L, Soares-da-Silva P (2008) Dosage form proportionality and food-effect of the final tablet formulation of eslicarbazepine acetatein healthy volunteers. Drugs R&D. 9(6): 447-454.

Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J, Laranjinha J, Heales S (2008) Glutamate Induces Release of Glutathione from Cultured Rat Astrocytes – A Possible Neuroprotective Mechanism? J. Neurochem. 105, 1144-1152.

Gago B, Nyström T, Cavaleiro C, Rocha BS, Barbosa R, Laranjinha J, Lundberg JO (2008) The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic. Biol. Med. 45, 404-412.

Lourenço CF, Gago B, Barbosa RM, de Freitas V, Laranjinha J (2008) LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion. J. Agric. Food Chem. 56, 3798-804.

Lumini-Oliveira J, Magalhães J, Oliveira PJ, Ascensão A (2008) Beneficial Effects of Exercise on Muscle Mitochondrial Function in Diabetes. Sports Medicine 38(9):735-50.

Maia J, Almeida L, Falcão AC, Soares E, Mota F, Potgieter MA, Potgieter JH, Soares-da-Silva P (2008) Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate. Int. J. Clin. Pharmacol. Ther. 46(3): 119-130.

Mano A, Falcão AC, Godinho I, Santos J, Leitão F, Oliveira C, Caramona MM (2008) CA-125 AUC as a predictor for ovarian cancer relapse. Cancer Biomarkers 4(2): 73-81.

Monteiro JP, Oliveira PJ, Moreno AJM and Jurado AS (2008) Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene. Relevance for toxicological assessment. Chemosphere 72: 1347-1354.

Monteiro JP, Oliveira PJ, Jurado A, Moreno AJ (2008) Disruption of Hepatic Mitochondrial Bioenergetics and Permeability Transition by the Insectice Methoprene – Relevance for Toxicological Assessment. Chemosphere 72(9):1347-54.

Monteiro JP, Videira R, Matos MJ, Dinis A and Jurado AS (2008) Non-selective toxicological effects of the insect juvenile hormone analogue methoprene. A membrane biophysical approach. Applied Biochemistry and Biotechnology 150:243-57.

Neves MAC, Dinis TCP, Colombo G and Melo MLS (2008) Biochemical and computational insights into the anti-aromatase activity of natural catechol estrogens. J. Steroid Biochem. Mol. Biol. 110 10-17.

Nunes C, Almeida L and Laranjinha J (2008) 3,4-dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning. Neurotoxicology 29, 998-1007.

Pereira CV, Machado NG, Oliveira PJ (2008) Mechanisms of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium]-induced Mitochondrial Dysfunction: Interaction with the Adenine Nucleotide Translocator. Toxicol. Sci. 105(2):408-17.

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ (2008) Mitochondria: The New Comeback of an Old Biosensor for Drug Safety. Curr. Drug Safety 4(1):34-54.

Pereira GC, Oliveira PJ (2008) Pharmacological Strategies to Counteract Doxorubicin-induced Cardiotoxicity – The Role of Mitochondria. J. Theor. Exp. Pharmacol. 1 (2): 39-53.

Pupure J, Fernandes MA, Santos MS, Moreno A J, Kalvinsh I, Klusa V, Oliveira CR (2008) Mitochondria as the target for mildronates´s protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria. Cell Biochem. Function 26:620-631.

Santos RM, Lourenço CF, Piedade AP, Andrews R, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J, Barbosa RM (2008) A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue. Biosensors Bioelectronics 24, 704-709.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB (2008) Morphological Hallmarks of Doxorubicin Toxicity on H9c2 Moblasts: Nuclear, Mitochondrial and Cytoskeletal Targets. Cell. Biol. Toxicol. 25(3):227-43.

Sardão VA, Pereira SL, Oliveira PJ. Drug-induced Mitochondrial Dysfunction in Cardiac and Skeletal Muscle Injury. Exp. Opin. Drug Safety. 7(2):129-46.

Serafim TL, Matos JAC, Sardão VA, Pereira GC, Branco AF, Pereira SL, Parke D, Perkins EL, Moreno AJM, Holy J, Oliveira PJ (2008) Sanguinarine Cytotoxicity on Mouse Melanoma K1735-M2 Cells – Nuclear versus Mitochondrial Effects. Biochem. Pharmacol. 76: 1459-1475.

Teodoro JS, Rolo AP, Duarte FV, Simões AM, Palmeira CM (2008) Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression. Mitochondrion 8(5-6):367-76.

Varela AT, Gomes AP, Simões A, Teodoro JS, Duarte FV, Rolo AP, Palmeira CM (2008) Indirubin-3 -oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction. Toxicol. Appl. Pharmacol. 233(2):179-85.

Vaz-da-Silva M, Loureiro A, Nunes T, Lopes C, Rocha J, Costa R, Torrão L, Falcão AC, Wright L, Almeida L, Soares-da-Silva P (2008) Pharmacokinetic-pharmacodynamic interaction between Nebicapone, a novel catechol-O-methyiltransferase inhibitor, and controlled release Levodopa/Carbidopa 200 mg/50 mg. Drugs R&D. 9(6): 435-446.

Vaz-da-Silva M, Loureiro AI, Falcão AC, Nunes T, Rocha JF, Fernandes-Lopes C, Soares E, Wright L, Almeida L, Soares-da-Silva P. (2008) Effect of food on the pharmacokinetic profile of trans-resveratrol. Int. J. Clin. Pharmacol. Ther. 46 (11): 564-570.