Toxicologia Celular e Molecular

Almeida L, Falcão AC, Vaz-da-Silva M, Soares E, Costa R, Loureiro A, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P (2009) Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Molecular Nutrition and Food Research. 53 (Suppl. 1): 7-15.

Alves E, Summavielle T, Alves CJ, Custódio JB, Fernandes E, de Lourdes Bastos M, Tavares MA, Carvalho F (2009) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict Biol. 14(2):185-93.

Alves G, Fortuna A, Falcão A (2009) Drug discovery and development process: bioanalytical framework supporting pharmacokinetic studies. International Journal of Medical and Biological Frontiers. 15:1043-1062.

Alves MG, Oliveira PJ, Carvalho RA (2009) Cardiac Mitochondrial Preservation in Celsior versus Histidine Buffer Solutions During Ischemia and Ischemia/Reperfusion. Cardiovasc. Toxicol. 9 (4): 185-193.

Amaral S, Mota P, Lacerda B, Alves M, Pereira ML, Oliveira PJ, Ramalho-Santos J (2009) Testicular Mitochondrial Alterations in Untreated Streptozotocin-induced Diabetic Rats, Mitochondrion 9(1):41-50.

Ascensão A, Lumini-Oliveira J, Pereira CV, Aleixo I, Oliveira PJ, Magalhães J (2009) Endurance Training Improves Gastrocnemius Mitochondrial Function Despite Increased Susceptibility to Permeability Transition. Mitochondrion, 9(6): 454-462.

Brito PM, Devillard R, Nègre-Salvayre A, Almeida LM, Dinis TCP, Salvayre R and Auge N (2009) Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis, 205, 126-134.

Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI (2009) Insulin is a two-edged knife on the brain. J. Alzheimers Dis. 18;483-507.

Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Li H, Casadesus G, Smith M, Perry G, Moreira P (2009) Insulin and insulin-sensitizing drugs in neurodegeneration: mitochondria as therapeutic targets. Pharmaceuticals, 2, 250-286.

Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI (2009) Doxorubicin: the good, the bad and the ugly effect. Curr. Med. Chem. 16:3267-85.

Castel-Branco MM, Alves GL, Figueiredo IV, Falcão AC, Caramona MM (2009) The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs. Methods & Findings in Experimental & Clinical Pharmacology. 31:101-106.

Coelho JFJ, Gois J, Fonseca AC, Carvalho RA, Popov AV, Percec V, Gil MH (2009) Synthesis of poly(2-methoxyethyl acrylate) by single electron transfer – degenerative transfer living radical polymerization catalyzed by Na2S2O4 in water. J. Polymer Sci. A – Polymer Chem. 47:4454-4463.

Costa VM, Ferreira LM, Branco PS, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem. Res. Toxicol. 22:129-135.

Costa VM, Silva R, Amado F, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F (2009) Redox behaviour of adrenaline under pro-oxidant conditions disrupts intracellular signalling pathways in freshly isolated cardiomyocytes. Toxicology 257: 70-79.

Costa VM, Silva R, Tavares LC, Vitorino R, Amado F, Carvalho F, Bastos ML, Carvalho M, Carvalho RA, Remião F (2009) Adrenaline incubation disrupts proteome homeostasis and alters mitochondrial activity and overall glucose metabolism in freshly isolated cardiomyocytes. Toxicology 260:84-96.

Custódio JB, Cardoso CM, Santos MS, Almeida LM, Vicente JA, Fernandes MA (2009) Cisplatin impairs rat liver mitochondrial functions by inducing changes on membrane ion permeability: prevention by thiol group protecting agents. Toxicology 259(1-2):18-24.

iculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2009) Electrochemical Oxidation of Berberine and of its Oxidation Products at a Glassy Carbon Electrode. Electroanalysis, 21 (9): 1027-1034.

Diculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2009) Electrochemical Oxidation of Sanguinarine and of its Oxidation Products at a Glassy Carbon Electrode – Relevance to Intracellular Effects. Electroanalysis 22 (1): 113-120.

Diogo CV, Félix L, Vilela S, Burgeiro A, Barbosa IA, Carvalho MJ, Oliveira PJ, Peixoto F (2009) Mitochondrial Toxicity of the Phytochemicals Daphnetoxin and Daphnoretin – Relevance for Possible Anti-cancer Application. Tox. In Vitro 23(5):772-729.

Duarte JMN, Carvalho RA, Cunha RA, Gruetter R (2009) Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. J. Neurochem. 111:368-379.

Fernandes MA, Santos MS, Moreno AJ, Chernova L, Krauze A, Duburs G, Vicente JA. Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function. Toxicol. In Vitro. 23(7): 1333-41.

Frade JG, Barbosa RM and Laranjinha J (2009) Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices. Hippocampus, 19, 603-611.

Justino LLG, Ramos ML, Abreu PE, Carvalho RA, AJFN Sobral, Scherf U, Burrows HD (2009) Conformational studies on poly(9,9-dialkylfluorene)s in solution using NMR spectroscopy and density functional theory calculations. J. Phys. Chem. B 113:11808-11821.

Machado N, Alves M, Carvalho RA, Oliveira PJ (2009) Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion – Can We Close the Box? Cardiovasc. Toxicol. 9 (4): 211–227.

Maia J, Coelho S, Lavrador I, Ventura C, Carvalho RA, Correia IJ, Gil MH (2009) Cellular adhesion and viability assessment on oxidized dextran-based hydrogels. Acta Biomaterialia 5:1948-1955.

Mota PC, Amaral SC, Martins L, Pereira ML, Oliveira PJ, Ramalho-Santos J (2009) Mitochondrial Bioenergetics of Testicular Cells from the Domestic Cat (Felis catus) - A Model for Endangered Species. Reprod.Toxicol. 27(2):111-116

Neves MAC, Dinis TCP, Colombo G and Sá e Melo ML (2009) An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. European Journal of Medicinal Chemistry 44, 4121-4127.

Neves MAC, Dinis TCP, Colombo G and Sá e Melo ML (2009) Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. Journal of Medicinal Chemistry 52, 143-150.

Nunes T, Almeida L, Rocha JF, Falcão AC, Fernandes-Lopes C, Loureiro AI, Wright L, Vaz-da-Silva M, Soares-da-Silva P (2009) Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and Young subjects. Journal of Clinical Pharmacology 49: 1477-1482.

Nunes T, Machado R, Rocha JF, Fernandes-Lopes C, Costa R, Torrão L, Loureiro AI, Falcão AC, Vaz-da-Silva M, Wright L, Almeida L, Soares-da-Silva P (2009) Pharmacokinetic-pharmacodynamic interaction between Nebicapone and Controlled-Release Levodopa/Benzserazide: a single-center, phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects. Clinical Therapeutics 31(10): 1-14.

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ (2009) Mitochondria: The New Comeback of an Old Biosensor for Drug Safety. Curr. Drug Safety 4(1):34-54.

Pereira SP, Fernandes MA, Martins JD, Santos MS, Moreno AJ, Vicente JA, Videira RA, Jurado AS. Toxicity assessment of the herbicide metolachlor comparative effects on bacterial and mitochondrial model systems. Toxicol In Vitro 23(8):1585-90.

Pereira SP, Pereira GC, Moreno AJ, Oliveira PJ (2009) Can We Predict Drug Safety and Reduce Animal Experiments by Using Isolated Mitochondrial Fractions as a Toxicity Biosensor? ATLA 37(4):355-365

Pinto MFV, Morán MC, Miguel MG, Lindman B, Jurado AS, Pais A. A. C. C. (2009). Controlling the morphology in DNA condensation and precipitation. Biomacromolecules10: 1319-1323.

Pinto RMA, Salvador JAR, Le Roux C, Carvalho RA, Matos Beja A, Paixão JA. (2009) Bismuth(III) triflate-catalyzed rearrangement of 16alpha,17alpha-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16alpha-substituted alpha-alkyl-17beta-methyl-delta13-18-norsteroids. Tetrahedron Lett. 65:6169-6178.

Pires A, Fortuna A, Alves G, Falcão A. (2009) Intranasal Drug Delivery: How, Why and What for? Journal of Pharmacy and Pharmaceutical Sciences. 12:288-311.

Rocha, BS, Gago, B, Barbosa RM and Laranjinha J. (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology, 265, 41-48.

Rocha JF, Falcão AC, Almeida L, Santos AT, Nunes T, Vaz-da-Silva M, Martins F, Fontes-Ribeiro C, Macedo T, Soares-da-Silva P (2009) Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics. 47(4): 255-261.

Rodrigues CFD, Urbano AM, Matoso E, Carreira I, Almeida A, Santos P, Botelho F, Carvalho L, Alves M, Monteiro C, Costa AN, Moreno V, Alpoim (2009) Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability. Mutat. Res. 670: 42-52.

Rodrigues C, Almeida A, Carreira IM, Matoso E, Urbano AM, Botelho MF, Carvalho L, Alves M, Monteiro C, Alpoim MC (2009) Hexavalent chromium and lung cancer: new perspectives. The FEBS J. 276: 339

Roleira FMF, Borges F, Andrade LCR, Paixão JA, Almeida MJM, Carvalho RA, Tavares da Silva EJ. (2009) Activation of hydrocinnamic acids with pentafluorophenol versus entafluorothiophenol. Reactivity towards hexylamine. J. Fluorine Chem. 130:169-174.

Rolo AP, Palmeira CM, Cortopassi GA. (2009) Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 385(1): 176-178.

Rolo AP, Teodoro JS, Peralta C, Rosello-Catafau J, Palmeira CM. (2009) Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition. Transpl Int. 22(11): 1081-1090.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB.(2009) Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol. 64(4): 811-827.

Soares AF, Viega FJ, Carvalho RA, Jones JG. (2009) Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal and ad-libitum feeding conditions. Magn. Res. Med. 61: 1-5.

Tavares RS, Martins F, Oliveira PJ, Ramalho-Santos J, Peixoto F (2009) Parabens in Male Infertility – Is There a Mitochondrial Connection? Reprod.Toxicol. 27(1):1-7

Vaz-da-Silva M, Costa R, Soares E, Maia J, Falcão AC, Almeida L, Soares-da-Silva P (2009) Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects. Fundamental and Clinical Pharmacology. 23: 509-514.